Publication Date:
1994-09-23
Description:
Indirect evidence implicates gamma delta T cells in the cross-regulation of CD4 alpha beta T cell responses. Adoptive transfer of small numbers of gamma delta T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without affecting parallel IgG responses. Challenge of these gamma delta T cells in vitro with specific antigen resulted in production of high levels of interferon gamma. The effects of the gamma delta T cells may be mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for specific CD4 TH2 cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMenamin, C -- Pimm, C -- McKersey, M -- Holt, P G -- New York, N.Y. -- Science. 1994 Sep 23;265(5180):1869-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell Biology, Institute for Child Health Research, West Perth, Western Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7916481" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CD4-Positive T-Lymphocytes/*immunology
;
Dose-Response Relationship, Immunologic
;
*Immune Tolerance
;
Immunoglobulin E/*biosynthesis
;
Immunoglobulin G/biosynthesis
;
Immunotherapy, Adoptive
;
Interferon-gamma/biosynthesis
;
Interleukin-2/biosynthesis
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred C57BL
;
Ovalbumin/immunology
;
Receptors, Antigen, T-Cell, gamma-delta/*immunology
;
T-Lymphocyte Subsets/*immunology
;
Transforming Growth Factor beta/biosynthesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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