Abstract
Indirect evidence implicates gamma delta T cells in the cross-regulation of CD4 alpha beta T cell responses. Adoptive transfer of small numbers of gamma delta T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without affecting parallel IgG responses. Challenge of these gamma delta T cells in vitro with specific antigen resulted in production of high levels of interferon gamma. The effects of the gamma delta T cells may be mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for specific CD4 TH2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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Dose-Response Relationship, Immunologic
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Immune Tolerance*
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Immunoglobulin E / biosynthesis*
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Immunoglobulin G / biosynthesis
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Immunotherapy, Adoptive
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Interferon-gamma / biosynthesis
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Interleukin-2 / biosynthesis
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Lymphocyte Activation
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Mice
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Mice, Inbred C57BL
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Ovalbumin / immunology
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Receptors, Antigen, T-Cell, gamma-delta / immunology*
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T-Lymphocyte Subsets / immunology*
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Transforming Growth Factor beta / biosynthesis
Substances
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Immunoglobulin G
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Interleukin-2
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Receptors, Antigen, T-Cell, gamma-delta
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Transforming Growth Factor beta
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Immunoglobulin E
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Interferon-gamma
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Ovalbumin