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  • 1
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    Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-19
    Description: Activity shapes the structure of neurons and their circuits. Two-photon imaging of CA1 neurons expressing enhanced green fluorescent protein in developing hippocampal slices from rat brains was used to characterize dendritic morphogenesis in response to synaptic activity. High-frequency focal synaptic stimulation induced a period (longer than 30 minutes) of enhanced growth of small filopodia-like protrusions (typically less than 5 micrometers long). Synaptically evoked growth was long-lasting and localized to dendritic regions close (less than 50 micrometers) to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors. Thus, synaptic activation can produce rapid input-specific changes in dendritic structure. Such persistent structural changes could contribute to the development of neural circuitry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maletic-Savatic, M -- Malinow, R -- Svoboda, K -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1923-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10082466" target="_blank"〉PubMed〈/a〉
    Keywords: 2-Amino-5-phosphonovalerate/pharmacology ; Animals ; Culture Techniques ; Dendrites/drug effects/physiology/*ultrastructure ; Electric Stimulation ; Excitatory Amino Acid Antagonists/pharmacology ; Green Fluorescent Proteins ; Hippocampus/cytology ; Luminescent Proteins/genetics ; Microscopy/methods ; Morphogenesis/drug effects ; Pseudopodia/drug effects/physiology/*ultrastructure ; Pyramidal Cells/physiology/*ultrastructure/virology ; Rats ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*physiology ; Sindbis Virus/genetics/physiology ; Synapses/*physiology/ultrastructure ; Synaptic Membranes/physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain" (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-08-01
    Description: We reported on a neural progenitor cell biomarker, a lipid-based metabolite enriched in these cells, which we detected using spectroscopy both in vitro and in vivo, and singular value decomposition-based signal processing. The study provided an outline of our computational methodology. Herein, we report more extensively on the method of spectrum analysis used, demonstrating the specificity of our findings.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576718/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576718/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Djuric, Petar M -- Benveniste, Helena -- Wagshul, Mark E -- Henn, Fritz -- Enikolopov, Grigori -- Maletic-Savatic, Mirjana -- K08 NS044276/NS/NINDS NIH HHS/ -- R21 NS053875/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2008 Aug 1;321(5889):640.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stony Brook University, Stony Brook, NY 11794, USA. djuric@ece.sunysb.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26380846" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers/*analysis ; Brain/*cytology ; *Cognition ; Humans ; Intelligence/*genetics ; Lipids/*analysis ; Magnetic Resonance Spectroscopy/*methods ; *Mutation ; Neurons/*cytology ; Schizophrenia/*genetics ; Stem Cells/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-11-10
    Description: The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039561/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039561/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manganas, Louis N -- Zhang, Xueying -- Li, Yao -- Hazel, Raphael D -- Smith, S David -- Wagshul, Mark E -- Henn, Fritz -- Benveniste, Helene -- Djuric, Petar M -- Enikolopov, Grigori -- Maletic-Savatic, Mirjana -- 5K08 NS044276/NS/NINDS NIH HHS/ -- K08 NS044276/NS/NINDS NIH HHS/ -- K08 NS044276-01/NS/NINDS NIH HHS/ -- R01 NS032764/NS/NINDS NIH HHS/ -- R01-NS32764/NS/NINDS NIH HHS/ -- R21 NS053875/NS/NINDS NIH HHS/ -- R21 NS053875-01A1/NS/NINDS NIH HHS/ -- R21NS05875-1/NS/NINDS NIH HHS/ -- T32DK07521-16/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Nov 9;318(5852):980-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉SUNY Stony Brook, Stony Brook, NY 11794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17991865" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Adult Stem Cells/chemistry/*cytology ; Algorithms ; Animals ; Biomarkers/analysis/chemistry ; Brain/cytology/embryology ; Brain Chemistry ; Cell Differentiation ; Child ; Embryonic Stem Cells/chemistry/cytology ; Fatty Acids/*analysis/chemistry ; Female ; Hippocampus/chemistry/*cytology ; Humans ; Magnetic Resonance Spectroscopy/*methods ; Male ; Mice ; Neurons/chemistry/*cytology ; Protons ; Rats ; Signal Processing, Computer-Assisted ; Stem Cells/chemistry/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Two-Photon Imaging in Living Brain Slices (1999)
    Elsevier
    Details
    Publication Date: 1999-06-01
    Print ISSN: 1046-2023
    Electronic ISSN: 1095-9130
    Topics: Biology , Medicine
    Published by Elsevier
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  • 5
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    Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity (1999)
    American Association for the Advancement of Science
    Details
    Publication Date: 1999-03-19
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science
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