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  • 1
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    Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: beta-arrestins are multifunctional proteins that act as scaffolds and transducers of intracellular signals from heptahelical transmembrane-spanning receptors (7TMR). Hedgehog (Hh) signaling, which uses the putative 7TMR, Smoothened, is established as a fundamental pathway in development, and unregulated Hh signaling is associated with certain malignancies. Here, we show that the functional knockdown of beta-arrestin 2 in zebrafish embryos recapitulates the many phenotypes of Hh pathway mutants. Expression of wild-type beta-arrestin 2, or constitutive activation of the Hh pathway downstream of Smoothened, rescues the phenotypes caused by beta-arrestin 2 deficiency. These results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate Hh signaling in zebrafish development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilbanks, Alyson M -- Fralish, Gregory B -- Kirby, Margaret L -- Barak, Larry S -- Li, Yin-Xiong -- Caron, Marc G -- GM069086-01/GM/NIGMS NIH HHS/ -- HL36059/HL/NHLBI NIH HHS/ -- HL61365/HL/NHLBI NIH HHS/ -- NS19576/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2264-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Science and Policy, Duke University Medical Center, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618520" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arrestins/genetics/*physiology ; Cell Differentiation ; Cyclic AMP-Dependent Protein Kinases/genetics/metabolism ; Embryo, Nonmammalian/metabolism ; Gene Expression Regulation, Developmental ; Hedgehog Proteins ; Homeodomain Proteins/genetics/metabolism ; In Situ Hybridization ; Membrane Proteins/genetics/metabolism ; Muscle Cells/cytology ; Muscle Fibers, Skeletal/cytology ; Mutation ; Phenotype ; Receptors, Cell Surface ; Receptors, G-Protein-Coupled/genetics/physiology ; Repressor Proteins/genetics/metabolism ; *Signal Transduction ; Trans-Activators/genetics/*metabolism ; Transcription Factors/genetics/metabolism ; Zebrafish/*embryology/genetics/*metabolism ; Zebrafish Proteins/genetics/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Dependence of thymus development on derivatives of the neural crest (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-03
    Description: Elimination of limited areas of the cephalic neural crest in stage 9 or 10 chick embryos markedly reduced the size of the thymus gland or resulted in its absence. Small thymic lobes contained both thymocytes and epithelial cells but showed delayed development. Parathyroid and thyroid glands sometimes were reduced in size or missing from the normal location on one or both sides. Heart defects were consistently present. Thymus development may depend on direct interaction of mesenchymal derivatives of the neural crest with pharyngeal epithelium. Multiple defects, such as the Di George syndrome, may result from failure of neural crest derivatives to migrate and interact properly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bockman, D E -- Kirby, M L -- HD17063/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 3;223(4635):498-500.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6606851" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Movement ; Chick Embryo ; Epithelial Cells ; Neural Crest/cytology/*physiology ; Organ Size ; Parathyroid Glands/embryology ; T-Lymphocytes/cytology ; Thymus Gland/cytology/*embryology ; Thyroid Gland/embryology ; Transposition of Great Vessels/embryology ; Truncus Arteriosus, Persistent/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Neural crest cells contribute to normal aorticopulmonary septation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-03
    Description: By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirby, M L -- Gale, T F -- Stewart, D E -- ND 17063/ND/ONDIEH CDC HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1059-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844926" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/*embryology ; Chick Embryo ; Chimera ; Coturnix ; Heart/embryology ; Heart Defects, Congenital/embryology ; Humans ; Lung/*embryology ; Neural Crest/*physiology ; Swine ; Transposition of Great Vessels/embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Role of extracardiac factors in heart development (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 944-951 
    Details
    ISSN: 1420-9071
    Keywords: Cardiac morphogenesis ; neural crest ; nodose placodes ; chick embryos ; heart malformations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Many factors extrinsic to the developing heart play important roles in determining its final form. The neural crest has been shown to provide ectomesenchyme to the pharyngeal apparatus and outflow tract, as well as the postganglionic innervation of the heart. Ablation of the neural crest providing ectomesenchyme to the outflow tract results in various cardiac malformations. These malformations have in common either outflow and/or inflow tract malalignment. Although the reason for this malalignment is not understood, it is thought that hemodynamic parameters during early cardiac morphogenesis may be disrupted causing cardiac dysmorphogenesis. The most likely area for this alteration to occur is in the pharyngeal apparatus which houses the aortic arch arteries. Various possibilities are discussed. The innervation of the heart by neural crest-derived autonomic neurons and nodose placode-derived sensory neurons is outlined, and the interactions between the two progenitive sites is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939888
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    Paper (German National Licenses)
    Fulltext
  • 5
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    Induction of Purkinje fiber differentiation by coronary arterialization (1999)
    National Academy of Sciences
    Details
    Publication Date: 1999-11-09
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 6
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    Role of extracardiac factors in heart development (1988)
    Springer
    Details
    Publication Date: 1988-12-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 7
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    Probabilistic Risk Assessment of Layered Pressure Vessels (2019)
    In:  CASI
    Details
    Publication Date: 2019-09-06
    Description: No abstract available
    Keywords: Mechanical Engineering
    Type: M19-7498 , ASME Pressure Vessels and Piping Conference PVP2019; Jul 14, 2019 - Jul 19, 2019; San Antionio, TX; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 8
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    Probabilistic Risk Assessment of Aging Layered Pressure Vessels (2019)
    In:  CASI
    Details
    Publication Date: 2019-09-06
    Description: The National Aeronautics and Space Administration (NASA) operates approximately 300 aging layered pressure vessels that were designed and manufactured prior to ASME Boiler and Pressure Vessel (B&PV) code requirements. In order to make decisions regarding the continued fitness-for-service of these non-code carbon steel vessels, it is necessary to perform a relative risk of failure assessment for each vessel. However, risk assessment of these vessels is confounded by uncertainties and variabilities related to the use of proprietary materials in fabrication, missing construction records, geometric discontinuities, weld residual stresses, and complex service stress gradients in and around the welds. Therefore, a probabilistic framework that can capture these uncertainties and variabilities has been developed to assess the fracture risk of flaws in regions of interest, such as longitudinal and circumferential welds, using the NESSUS probabilistic modeling software and NASGRO fracture mechanics software. In this study, the probabilistic framework was used to predict variability in the stress intensity factor associated with different reference flaws located in the head-to-shell circumferential welds of a 4-layer and 14-layer pressure vessel. The probabilistic studies predict variability in flaw behavior and the important uncertain parameters for each reference flaw location.
    Keywords: Structural Mechanics; Quality Assurance and Reliability
    Type: M19-7277 , ASME Pressure Vessels and Piping Conference (PVP) 2019; Jul 14, 2019 - Jul 19, 2019; San Antonio, TX; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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