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  • 1
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    Phonon pressure coefficients and deformation potentials of wurtzite AlN determined by uniaxial pressure-dependent Raman measurements (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-11-08
    Description: Author(s): G. Callsen, M. R. Wagner, J. S. Reparaz, F. Nippert, T. Kure, S. Kalinowski, A. Hoffmann, M. J. Ford, M. R. Phillips, R. F. Dalmau, R. Schlesser, R. Collazo, and Z. Sitar We studied bulk crystals of wurtzite AlN by means of uniaxial pressure-dependent Raman measurements. As a result, we derive the phonon pressure coefficients and deformation potentials for all zone center optical phonon modes. For the A1 and E1 modes, we further experimentally determined the uniaxial... [Phys. Rev. B 90, 205206] Published Fri Nov 07, 2014
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    A retrospective analysis of funding and focus in US advanced fission innovation (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-08-10
    Description: Deep decarbonization of the global energy system will require large investments in energy innovation and the deployment of new technologies. While many studies have focused on the expenditure that will be needed, here we focus on how government has spent public sector resources on innovation for a key carbon-free technology: advanced nuclear. We focus on nuclear power because it has been contributing almost 20% of total US electric generation, and because the US program in this area has historically been the world’s leading effort. Using extensive data acquired through the Freedom of Information Act, we reconstruct the budget history of the Department of Energy’s program to develop advanced, non-light water nuclear reactors. Our analysis shows that—despite spending $2 billion since the late 1990s—no advanced design is ready for deployment. Even if the program had been well designed, it still would have been insufficient to demonstrate even one non-light water technology. ...
    Print ISSN: 1748-9318
    Electronic ISSN: 1748-9326
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Institute of Physics (IOP)
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  • 3
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    Primate transcript and protein expression levels evolve under compensatory selection pressures (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-10-19
    Description: Changes in gene regulation have likely played an important role in the evolution of primates. Differences in messenger RNA (mRNA) expression levels across primates have often been documented; however, it is not yet known to what extent measurements of divergence in mRNA levels reflect divergence in protein expression levels, which are probably more important in determining phenotypic differences. We used high-resolution, quantitative mass spectrometry to collect protein expression measurements from human, chimpanzee, and rhesus macaque lymphoblastoid cell lines and compared them to transcript expression data from the same samples. We found dozens of genes with significant expression differences between species at the mRNA level yet little or no difference in protein expression. Overall, our data suggest that protein expression levels evolve under stronger evolutionary constraint than mRNA levels.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994702/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994702/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khan, Zia -- Ford, Michael J -- Cusanovich, Darren A -- Mitrano, Amy -- Pritchard, Jonathan K -- Gilad, Yoav -- F32HG006972/HG/NHGRI NIH HHS/ -- GM077959/GM/NIGMS NIH HHS/ -- R01 GM077959/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1100-4. doi: 10.1126/science.1242379. Epub 2013 Oct 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24136357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Evolution, Molecular ; *Gene Expression Regulation ; Humans ; Macaca mulatta/*genetics ; Pan troglodytes/*genetics ; Protein Biosynthesis/*genetics ; RNA, Messenger/*biosynthesis/genetics ; *Selection, Genetic ; Species Specificity ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Genomic variation. Impact of regulatory variation from RNA to protein (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-02-07
    Description: The phenotypic consequences of expression quantitative trait loci (eQTLs) are presumably due to their effects on protein expression levels. Yet the impact of genetic variation, including eQTLs, on protein levels remains poorly understood. To address this, we mapped genetic variants that are associated with eQTLs, ribosome occupancy (rQTLs), or protein abundance (pQTLs). We found that most QTLs are associated with transcript expression levels, with consequent effects on ribosome and protein levels. However, eQTLs tend to have significantly reduced effect sizes on protein levels, which suggests that their potential impact on downstream phenotypes is often attenuated or buffered. Additionally, we identified a class of cis QTLs that affect protein abundance with little or no effect on messenger RNA or ribosome levels, which suggests that they may arise from differences in posttranslational regulation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507520/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507520/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Battle, Alexis -- Khan, Zia -- Wang, Sidney H -- Mitrano, Amy -- Ford, Michael J -- Pritchard, Jonathan K -- Gilad, Yoav -- F32 HG006972/HG/NHGRI NIH HHS/ -- F32HG006972/HG/NHGRI NIH HHS/ -- GM077959/GM/NIGMS NIH HHS/ -- HG007036/HG/NHGRI NIH HHS/ -- MH084703/MH/NIMH NIH HHS/ -- R01 GM077959/GM/NIGMS NIH HHS/ -- R01 MH084703/MH/NIMH NIH HHS/ -- U01 HG007036/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Feb 6;347(6222):664-7. doi: 10.1126/science.1260793. Epub 2014 Dec 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Stanford University, Stanford, CA 94305, USA. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. ; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. ; MS Bioworks, LLC, 3950 Varsity Drive, Ann Arbor, MI 48108, USA. ; Department of Genetics, Stanford University, Stanford, CA 94305, USA. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Department of Biology, Stanford University, Stanford, CA 94305, USA. pritch@stanford.edu gilad@uchicago.edu. ; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. pritch@stanford.edu gilad@uchicago.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25657249" target="_blank"〉PubMed〈/a〉
    Keywords: 3' Flanking Region ; 5' Flanking Region ; Cell Line ; Exons ; *Gene Expression Regulation ; *Genetic Variation ; Humans ; Phenotype ; Protein Biosynthesis/*genetics ; *Quantitative Trait Loci ; RNA, Messenger/*genetics ; Ribosomes/metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Hydrogen adsorption capacity of adatoms on double carbon vacancies of graphene: A trend study from first principles (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-01-04
    Description: Author(s): K. M. Fair, X. Y. Cui, L. Li, C. C. Shieh, R. K. Zheng, Z. W. Liu, B. Delley, M. J. Ford, S. P. Ringer, and C. Stampfl Structural stability and hydrogen adsorption capacity are two key quantities in evaluating the potential of metal-adatom decorated graphene for hydrogen storage and related devices. We have carried out extensive density functional theory calculations for the adsorption of hydrogen molecules on 12 di... [Phys. Rev. B 87, 014102] Published Thu Jan 03, 2013
    Keywords: Structure, structural phase transitions, mechanical properties, defects
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
    Electronic Resource
    Electronic Resource
    An integral equation approach to internal (2-layer) solitary waves (1996)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 8 (1996), S. 2032-2047 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The exact within potential flow integral equation approach of Evans and Ford [Proc. R. Soc. London Ser. A 452, 373 (1996)] for the normal solitary wave, is here generalized to 2-layer, "internal'' solitary waves. This differs in its mathematical form from other exact integral equation methods based on the complex velocity potential. For both "rigid lid'' (i.e., flat toplayer surface) and "free-surface'' boundary conditions, a set of coupled non-linear integral equations are derived by an application of Green's theorem. For each point on the layer interface(s), these describe functional constraints on the profiles and interface fluid velocity moduli; the exact profiles and velocities being those forms that satisfy these constraints at all such interface points. Using suitable parametric representations of the profiles and interface velocity moduli as functions of horizontal distance, x, and utilizing tailored quadrature methods [Int. J. Comput. Math. B 6, 219 (1977)], numerical solutions were obtained by the Newton–Raphson method that are highly accurate even at large amplitudes. For "rigid lid'' boundary conditions, internal wave solutions are presented for layer density and depth ratios typical of oceanic internal wave phenomena as found in the Earth's marginal seas. Their various properties, i.e., mass, momentum, energy, circulation, phase and fluid velocities, streamline profiles, internal pressures, etc., are evaluated and compared, where possible, with observed properties of such phenomena as reported, for example, from the Andaman Sea. The nature of the limiting (or "maximum'') internal wave is investigated asymptotically and argued to be consistent with two "surge'' regions separating the outskirts flow from a wide mid-section region of uniform "conjugate flow'' as advocated by Turner and Vanden-Broeck [Phys. Fluids 31, 286 (1988)]. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.869006
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple detector triple coincidence spectrometer for (e,3e) electron impact double-ionization measurements (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 3137-3143 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An (e,3e) spectrometer for the study of double ionization of magnesium by electron impact is described. With the spectrometer the angular and energy distributions of the ejected electrons can be measured over a range of incident-electron energies. The spectrometer incorporates two ejected-electron electrostatic energy analyzers and a tandem electrostatic analyzer for the scattered electrons. Up to eight detectors can be placed at the focal planes of each of the ejected analyzers. This increases the data rate by a factor of 64 over arrangements with two ejected-electron detectors. In order to reduce noise and establish the energy of the final state of the doubly charged residual magnesium ion, triple-coincidence electronics are used with a preprocessing circuit to reduce dead time. The first double-ionization study with the instrument was the ejection of a 2p inner valence electron by a 3.5 keV incident electron accompanied by the subsequent filling of the 2p hole and the emission of a 35 eV Auger electron. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145542
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  • 8
    Electronic Resource
    Electronic Resource
    Histogramming data acquisition system for an (e,2e) coincidence experiment (1992)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 63 (1992), S. 1922-1926 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A four-dimensional histogramming data acquisition system has been developed for use on an 80386 IBM-compatible computer. The method has a large data storage capacity providing good experimental resolution and system flexibility. A custom-built analog-to-digital board generates a memory address in hardware from the incoming data which permit the use of a simple and elegant histogramming algorithm. The system is used to collect and analyze data from (e,2e) experiments. Results from coplanar symmetric (e,2e) experiments on argon, at an incident energy of 3 keV, are presented to demonstrate the performance of the instrument. The method is applicable to experiments where data from several sources have to be combined and then histogrammed in real time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1143305
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  • 9
    Electronic Resource
    Electronic Resource
    Nuclear protein with sequence homology to translation initiation factor eIF-4A (1988)
    [s.l.] : Nature Publishing Group
    Nature 332 (1988), S. 736-738 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The sequence of the p68 protein was determined from a number of independent cDNA clones obtained from two different cDNA libraries. Initially a Agtll library made from human hepatoma messenger RNA (ref. 6) was screened using the PAb204 antibody and an immunoperoxidase detection system. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/332736a0
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  • 10
    Electronic Resource
    Electronic Resource
    A re-examination of the reputed control of cotyledonary metabolism by the axis (1976)
    Springer
    Planta 132 (1976), S. 205-208 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A re-examination has been made of the supposed regulation by the axis of cotyledonary isocitrate lyase (EC 4.1.3.1) activity in Cucumis sativas L. and Cucurbita maxima Duch. and greening in cucumis. When precautions are taken to ensure that isolated cotyledons and cotyledons attached to the axis have equal access to oxygen and/or water no axis effects can be observed. The results underline the importance of maintaining excised plant parts in comparable physical conditions if meaningful physiological measurements are to be made. Previous reports describing a controlling role for the axis are therefore most probably incorrect, although alternative regulatory mechanisms mediated by the axis are still possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388904
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