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  • 1
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    Application of U-Th-Pb Phosphate Geochronology to Young Orogenic Gold Deposits: New Age Constraints on the Formation of the Grass Valley Gold District, Sierra Nevada Foothills Province, California (2015)
    Society of Economic Geologists (SEG)
    Details
    Publication Date: 2015-05-23
    Description: The Grass Valley orogenic gold district in the Sierra Nevada foothills province, central California, the largest historic gold producer of the North American Cordillera, comprises both steeply dipping E-W veins located along lithologic contacts in accreted ca. 300 and 200 Ma oceanic rocks and shallowly dipping N-S veins hosted by the Grass Valley granodiorite; the latter have yielded about 70% of the 13 million ounces of historic lode gold production in the district. The oceanic host rocks were accreted to the western margin of North America between 200 and 170 Ma, metamorphosed to greenschist and amphibolite facies, and uplifted between 175 and 160 Ma. Large-scale magmatism in the Sierra Nevada occurred between 170 to 140 Ma and 120 to 80 Ma, with the Grass Valley granodiorite being emplaced during the older episode of magmatism. Uranium-lead isotope dating of hydrothermal xenotime yielded the first absolute age of 162 ± 5 Ma for the economically more significant N-S veins. The vein-hosted xenotime, as well as associated monazite, are unequivocally of hydrothermal origin as indicated by textural and chemical characteristics, including grain shape, lack of truncated growth banding, lack of an Eu anomaly, and low U and Th concentrations. Furthermore, the crack-seal texture of the veins, with abundant wall-rock slivers, suggests their formation as a result of episodic fluid flow possibly related to reoccurring seismic events, rather than a period of fluid exsolution from an evolving magma. The N-S veins are temporally distinct from a younger 153 to 151 Ma gold event that was previously reported for the E-W veins. Overlapping U-Pb zircon (159.9 ± 2.2 Ma) and 40 Ar/ 39 Ar biotite and hornblende (159.7 ± 0.6–161.9 ± 1.4 Ma) ages and geothermobarometric calculations indicate that the Grass Valley granodiorite was emplaced at ca. 160 Ma at elevated temperatures (~800°C) within approximately 3 km of the paleosurface and rapidly cooled to the ambient temperature of the surrounding country rocks (〈300°C). The age of the granodiorite is indistinguishable from that of the N-S veins, as recorded by the U-Pb age of xenotime in those veins. Consequently, the N-S veins must have formed between 162 and 157 Ma, the maximum permissive age of magma emplacement and the youngest permissive xenotime U-Pb age, respectively, during an E- to ENE-directed compressional regime. The geochemistry of the Grass Valley granodiorite is consistent with it being the product of arc magmatism. It served as a receptive host for mineralization, but it is has no direct genetic relationship to gold mineralization. Initial uplift of the intrusive mass correlates with the initial voluminous fluid flow event and vein formation at depths of no greater than 3 km. The E-W gold-bearing veins hosted within greenschist-facies country rocks adjacent to the intrusion formed during a second hydrothermal event 5 to 10 million years later than the magmatism and were contemporaneous with a shift to transtensional deformation denoted by sinistral strike-slip faulting.
    Print ISSN: 0361-0128
    Topics: Geosciences
    Published by Society of Economic Geologists (SEG)
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  • 2
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    Monochromatic electron photoemission from diamondoid monolayers (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-06-09
    Description: We found monochromatic electron photoemission from large-area self-assembled monolayers of a functionalized diamondoid, [121]tetramantane-6-thiol. Photoelectron spectra of the diamondoid monolayers exhibited a peak at the low-kinetic energy threshold; up to 68% of all emitted electrons were emitted within this single energy peak. The intensity of the emission peak is indicative of diamondoids being negative electron affinity materials. With an energy distribution width of less than 0.5 electron volts, this source of monochromatic electrons may find application in technologies such as electron microscopy, electron beam lithography, and field-emission flat-panel displays.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, W L -- Fabbri, J D -- Willey, T M -- Lee, J R I -- Dahl, J E -- Carlson, R M K -- Schreiner, P R -- Fokin, A A -- Tkachenko, B A -- Fokina, N A -- Meevasana, W -- Mannella, N -- Tanaka, K -- Zhou, X J -- van Buuren, T -- Kelly, M A -- Hussain, Z -- Melosh, N A -- Shen, Z-X -- New York, N.Y. -- Science. 2007 Jun 8;316(5830):1460-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geballe Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17556579" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Climate. Was the Younger Dryas global? (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lowell, Thomas V -- Kelly, Meredith A -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):348-9. doi: 10.1126/science.1160148.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology, University of Cincinnati, Cincinnati, OH 45221, USA. thomas.lowell@uc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635782" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Mesoscopic percolating resistance network in a strained manganite thin film (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-10
    Description: Many unusual behaviors in complex oxides are deeply associated with the spontaneous emergence of microscopic phase separation. Depending on the underlying mechanism, the competing phases can form ordered or random patterns at vastly different length scales. By using a microwave impedance microscope, we observed an orientation-ordered percolating network in strained Nd(1/2)Sr(1/2)MnO3 thin films with a large period of 100 nanometers. The filamentary metallic domains align preferentially along certain crystal axes of the substrate, suggesting the anisotropic elastic strain as the key interaction in this system. The local impedance maps provide microscopic electrical information of the hysteretic behavior in strained thin film manganites, suggesting close connection between the glassy order and the colossal magnetoresistance effects at low temperatures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lai, Keji -- Nakamura, Masao -- Kundhikanjana, Worasom -- Kawasaki, Masashi -- Tokura, Yoshinori -- Kelly, Michael A -- Shen, Zhi-Xun -- New York, N.Y. -- Science. 2010 Jul 9;329(5988):190-3. doi: 10.1126/science.1189925.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geballe Laboratory for Advanced Materials, Department of Physics, Stanford University, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20616272" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Health and population effects of rare gene knockouts in adult humans with related parents (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-03-05
    Description: Examining complete gene knockouts within a viable organism can inform on gene function. We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental relatedness, discovering 1111 rare-variant homozygous genotypes with predicted loss of function (knockouts) in 781 genes. We observed 13.7% fewer homozygous knockout genotypes than we expected, implying an average load of 1.6 recessive-lethal-equivalent loss-of-function (LOF) variants per adult. When genetic data were linked to the individuals' lifelong health records, we observed no significant relationship between gene knockouts and clinical consultation or prescription rate. In this data set, we identified a healthy PRDM9-knockout mother and performed phased genome sequencing on her, her child, and control individuals. Our results show that meiotic recombination sites are localized away from PRDM9-dependent hotspots. Thus, natural LOF variants inform on essential genetic loci and demonstrate PRDM9 redundancy in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Narasimhan, Vagheesh M -- Hunt, Karen A -- Mason, Dan -- Baker, Christopher L -- Karczewski, Konrad J -- Barnes, Michael R -- Barnett, Anthony H -- Bates, Chris -- Bellary, Srikanth -- Bockett, Nicholas A -- Giorda, Kristina -- Griffiths, Christopher J -- Hemingway, Harry -- Jia, Zhilong -- Kelly, M Ann -- Khawaja, Hajrah A -- Lek, Monkol -- McCarthy, Shane -- McEachan, Rosie -- O'Donnell-Luria, Anne -- Paigen, Kenneth -- Parisinos, Constantinos A -- Sheridan, Eamonn -- Southgate, Laura -- Tee, Louise -- Thomas, Mark -- Xue, Yali -- Schnall-Levin, Michael -- Petkov, Petko M -- Tyler-Smith, Chris -- Maher, Eamonn R -- Trembath, Richard C -- MacArthur, Daniel G -- Wright, John -- Durbin, Richard -- van Heel, David A -- GM 099640/GM/NIGMS NIH HHS/ -- MR/M009017/1/Medical Research Council/United Kingdom -- R01 GM104371/GM/NIGMS NIH HHS/ -- R01GM104371/GM/NIGMS NIH HHS/ -- WT098051/Wellcome Trust/United Kingdom -- WT099769/Wellcome Trust/United Kingdom -- WT101597/Wellcome Trust/United Kingdom -- WT102627/Wellcome Trust/United Kingdom -- British Heart Foundation/United Kingdom -- Arthritis Research UK/United Kingdom -- Cancer Research UK/United Kingdom -- Department of Health/United Kingdom -- Chief Scientist Office/United Kingdom -- New York, N.Y. -- Science. 2016 Apr 22;352(6284):474-7. doi: 10.1126/science.aac8624. Epub 2016 Mar 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. ; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. ; Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust, Bradford BD9 6RJ, UK. ; Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME 04609, USA. ; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. ; Diabetes and Endocrine Centre, Heart of England NHS Foundation Trust and University of Birmingham, Birmingham B9 5SS, UK. ; TPP, Mill House, Troy Road, Leeds LS18 5TN, UK. ; Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, UK. ; 10X Genomics, 7068 Koll Center Parkway, Suite 415, Pleasanton, CA 94566, USA. ; Farr Institute of Health Informatics Research, London NW1 2DA, UK. Institute of Health Informatics, University College London, London NW1 2DA, UK. ; School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK. ; Department of Medical Genetics, University of Cambridge and National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Box 238, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. ; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. Faculty of Life Sciences and Medicine, King's College London, London SE1 1UL, UK. ; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. rd@sanger.ac.uk d.vanheel@qmul.ac.uk. ; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. rd@sanger.ac.uk d.vanheel@qmul.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26940866" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Consanguinity ; DNA Mutational Analysis ; Drug Prescriptions ; Exome/genetics ; Female ; Fertility ; Gene Knockout Techniques ; Genes, Lethal ; Genetic Loci ; Genome, Human ; Great Britain ; *Health ; Histone-Lysine N-Methyltransferase/*genetics ; Homologous Recombination ; Homozygote ; Humans ; Male ; Mothers ; Pakistan/ethnology ; Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Forest canopy closure buffers warming effects [Ecology] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-11-13
    Description: Recent global warming is acting across marine, freshwater, and terrestrial ecosystems to favor species adapted to warmer conditions and/or reduce the abundance of cold-adapted organisms (i.e., “thermophilization” of communities). Lack of community responses to increased temperature, however, has also been reported for several taxa and regions, suggesting that “climatic lags”...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    The tropical lapse rate steepened during the Last Glacial Maximum (2017)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2017-01-28
    Description: The gradient of air temperature with elevation (the temperature lapse rate) in the tropics is predicted to become less steep during the coming century as surface temperature rises, enhancing the threat of warming in high-mountain environments. However, the sensitivity of the lapse rate to climate change is uncertain because of poor constraints on high-elevation temperature during past climate states. We present a 25,000-year temperature reconstruction from Mount Kenya, East Africa, which demonstrates that cooling during the Last Glacial Maximum was amplified with elevation and hence that the lapse rate was significantly steeper than today. Comparison of our data with paleoclimate simulations indicates that state-of-the-art models underestimate this lapse-rate change. Consequently, future high-elevation tropical warming may be even greater than predicted.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Choice of biodiversity index drives optimal fire management decisions (2015)
    Wiley
    Details
    Publication Date: 2015-01-01
    Description: Preservation of biodiversity is a central goal of conservation management, yet the conditions that promote persistence may differ for the species in the community. For systems subject to stochastic disturbances such as fire, understanding which management practices promote persistence for all species in a community is complex. Before deciding on the best course of action, an objective must be specified. Yet an overarching goal of species persistence can be specified into a measureable objective many different ways. We investigated four alternative management objectives for maximizing species persistence that use common biodiversity indices: (1) attaining the minimally acceptable mix of successional vegetation states to support species' relative abundances, (2) maximizing the arithmetic mean abundance of species, (3) maximizing the geometric mean abundance of species, and (4) minimizing the average extinction risk of species. We used stochastic dynamic programming to model successional changes in vegetation in the presence of both planned and unplanned fires, and utilize an extensive data set on the occurrence of birds, reptiles, and small mammals in different successional states in semiarid Australia. We investigated the influence the choice of objective function and taxonomic focus has on the optimal fire management recommendations. We also evaluated a recent hazard reduction policy to annually burn a fixed amount of the landscape and compare results to the optimal solution. The optimal management strategy to maximize species persistence over a 100-year period is predominantly to minimize wildfires. This is because the majority of species are more likely to occur in intermediate and late successional vegetation. However the optimal solution showed sensitivity to the objective and the species included in the analysis. These results highlight the need for careful consideration when specifying an objective to represent overarching conservation goals. Using the extinction risk objective, we show that a policy to annually burn 5% of the landscape could increase the average probability of extinction for the modelled species by 7% over the next 100 years compared to the optimal management scenario. # doi:10.1890/14-0257.1
    Print ISSN: 1051-0761
    Electronic ISSN: 1939-5582
    Topics: Biology
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 9
    Electronic Resource
    Electronic Resource
    The use of a short-end injection procedure to achieve improved performance in capillary electrophoresis (1996)
    Springer
    Chromatographia 43 (1996), S. 153-158 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Short-end injections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Minimum capillary lengths on commercial instruments are fixed and cannot be decreased further. To effectively reduce the capillary length used for separation the sample can be injected from the end of the capillary nearest the detector. This procedure is known as a ‘short-end’ injection and can reduces analysis times by at least two-thirds compared to conventional injections. The time reduction benefits are shown in rapid separations of basic drugs, drug-related impurities and chiral compounds. Short-end injections, in combination with both increased electrolyte strength and reduced voltage are an effective approach to reducing the detrimental impact of high sample solution ionic strength. They can also lead to improved resolution by increasing stacking effects and reducing peak tailing. Peak area and migration time precision obtained are shown to be equivalent to those obtained for conventional injection procedures. It is concluded that short-end injections should be considered for routine operation as they are a useful means of reducing analysis time, increasing sensitivity, decreasing buffer depletion effects. They also allow use of higher electrolyte strengths which can improve resolution and reduce peak tailing, and can overcome significant problems which occur when analysing samples containing high salt contents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02292944
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  • 10
    Electronic Resource
    Electronic Resource
    Applications of the small spot ESCA system SSX 100 in surface analysis (1984)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 319 (1984), S. 845-847 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Evidence is presented that old ESCA limitations and restrictions (e.g. big X-ray beam diameter or small “unrealistic” size of samples) are not valid any longer. The new SSX 100 ESCA spectrometer with its unique combination of ESCA innovations (focusing monochromator, parallel imaging detectors, high throughput electron optics and improved sample handling) makes solving surface problems much easier. Two applications on semiconductors and insulators using the small spot X-ray beam (diameter: 150 μm) demonstrate that small spot ESCA technique now can be applied on problems which could not be solved with conventional ESCA technique hitherto.
    Notes: Zusammenfassung Es wird gezeigt, daß bisherige Limitierungen und Restriktionen in der Anwendung der ESCA-Technik (z.B. der relativ große Strahldurchmesser oder die kleine „unrealistische“ Probengröße) nicht länger gültig sind. Das neue SSX 100 ESCA-System hilft bei der Lösung von Oberflächenproblemen ganz erheblich aufgrund seiner einzigartigen Kombination von sinnvollen und hilfreichen Innovationen (z.B. fokussierender Monochromator, parallel abbildender Detektor, effektive Elektronenoptik und ver besserte Probenhandhabung). Zwei Anwendungen bei Halbleitern und Isolatoren unter Benutzung des feinfokussierten Röntgenstrahls (Durchmesser: 150 μm) zeigen, daß die „small spot“ ESCA-Technik jetzt erfolgreich bei Problemen angewandt werden kann, die bisher mit konventionellem ESCA nicht zu lösen waren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01226785
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