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  • 1
    Publication Date: 2022-08-05
    Description: This work documents the ICON‐Earth System Model (ICON‐ESM V1.0), the first coupled model based on the ICON (ICOsahedral Non‐hydrostatic) framework with its unstructured, icosahedral grid concept. The ICON‐A atmosphere uses a nonhydrostatic dynamical core and the ocean model ICON‐O builds on the same ICON infrastructure, but applies the Boussinesq and hydrostatic approximation and includes a sea‐ice model. The ICON‐Land module provides a new framework for the modeling of land processes and the terrestrial carbon cycle. The oceanic carbon cycle and biogeochemistry are represented by the Hamburg Ocean Carbon Cycle module. We describe the tuning and spin‐up of a base‐line version at a resolution typical for models participating in the Coupled Model Intercomparison Project (CMIP). The performance of ICON‐ESM is assessed by means of a set of standard CMIP6 simulations. Achievements are well‐balanced top‐of‐atmosphere radiation, stable key climate quantities in the control simulation, and a good representation of the historical surface temperature evolution. The model has overall biases, which are comparable to those of other CMIP models, but ICON‐ESM performs less well than its predecessor, the Max Planck Institute Earth System Model. Problematic biases are diagnosed in ICON‐ESM in the vertical cloud distribution and the mean zonal wind field. In the ocean, sub‐surface temperature and salinity biases are of concern as is a too strong seasonal cycle of the sea‐ice cover in both hemispheres. ICON‐ESM V1.0 serves as a basis for further developments that will take advantage of ICON‐specific properties such as spatially varying resolution, and configurations at very high resolution.
    Description: Plain Language Summary: ICON‐ESM is a completely new coupled climate and earth system model that applies novel design principles and numerical techniques. The atmosphere model applies a non‐hydrostatic dynamical core, both atmosphere and ocean models apply unstructured meshes, and the model is adapted for high‐performance computing systems. This article describes how the component models for atmosphere, land, and ocean are coupled together and how we achieve a stable climate by setting certain tuning parameters and performing sensitivity experiments. We evaluate the performance of our new model by running a set of experiments under pre‐industrial and historical climate conditions as well as a set of idealized greenhouse‐gas‐increase experiments. These experiments were designed by the Coupled Model Intercomparison Project (CMIP) and allow us to compare the results to those from other CMIP models and the predecessor of our model, the Max Planck Institute for Meteorology Earth System Model. While we diagnose overall satisfactory performance, we find that ICON‐ESM features somewhat larger biases in several quantities compared to its predecessor at comparable grid resolution. We emphasize that the present configuration serves as a basis from where future development steps will open up new perspectives in earth system modeling.
    Description: Key Points: This work documents ICON‐ESM 1.0, the first version of a coupled model based on the ICON framework. Performance of ICON‐ESM is assessed by means of CMIP6 Diagnosis, Evaluation, and Characterization of Klima experiments at standard CMIP‐type resolution. ICON‐ESM reproduces the observed temperature evolution. Biases in clouds, winds, sea‐ice, and ocean properties are larger than in MPI‐ESM.
    Description: European Union H2020 ESM2025
    Description: European Union H2020 COMFORT
    Description: European Union H2020ESiWACE2
    Description: Deutsche Forschungsgemeinschaft TRR181
    Description: Deutsche Forschungsgemeinschaft EXC 2037
    Description: European Union H2020
    Description: Deutscher Wetterdienst
    Description: Bundesministerium fuer Bildung und Forschung
    Description: http://esgf-data.dkrz.de/search/cmip6-dkrz/
    Description: https://mpimet.mpg.de/en/science/modeling-with-icon/code-availability
    Description: http://cera-www.dkrz.de/WDCC/ui/Compact.jsp?acronym=RUBY-0_ICON-_ESM_V1.0_Model
    Keywords: ddc:550.285 ; ddc:551.63
    Language: English
    Type: doc-type:article
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 28 (1956), S. 1366-1368 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 24 (1952), S. 1117-1119 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 86 (1964), S. 5011-5012 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 86 (1964), S. 5012-5013 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 79 (1957), S. 6495-6500 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 195 (1986), S. 513-518 
    ISSN: 1432-041X
    Keywords: Regeneration ; Distal transformation ; Cell ; aggregation ; Cnidaria ; Hydractinia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Polyps of mature colonies of Hydractinia echinata obey the “rule of distal transformation” by regenerating heads but not stolons. However, this rule is not valid for young polyps as these regenerate stolons from proximal cut ends. Also, small cell aggregates and even small fragments excised from full-grown polyps are capable of stolon formation. Aggregates produced from dissociated cells undergo either distal or proximal transformation depending on their size, speed of head regeneration in the donor used for dissociation and the positional derivation of the cells. The latent capability of stolon formation is released under conditions that cause loss of morphogens and depletion of their sources. However, internal regulative processes can also lead to gradual proximal transformation: regenerating segments of polyps sometimes form heads at both ends and the distal pattern is duplicated. Subsequently, all sets of proximal structures, including stolons, are intercalated. In contrast to distal transformation, proximal transformation is a process the velocity of which declines with the age and size of the cell community.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Development genes and evolution 170 (1972), S. 152-164 
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Die Wirkung von SH- und SS-Gruppen beeinflussenden Reagenzien auf die Morphogenese wurde am Beispiel regenerierender adulter Nährpolypen und bei der Larvenmetamorphose untersucht. Die Hauptwirkung der Agentien besteht, sofern sie über eine allgemeine Schädigung hinausgeht, in der Auslösung und Verstärkung basaler Differenzierung. 2. Bei Larven, die sich in der Metamorphose befinden, führt Inkubation mit dem SS-reduzierenden Reagens Dithioerythrit (0.12–0.25 mM) zu einer Verlängerung des subtentakulären Polypenabschnitts. Dimercaptopropanol (0.19 mM) verstärkt, wie auch einige andere Thiol-Reagenzien, spezifisch die Stolobildung und es wachsen stark verbreiterte Stolone aus. Unter dem Einfluß des SH-Gruppen oxidierenden Kosower-Reagens „Diamide“ entwickeln die Larven eine übermäßig vergrößerte Hydrorhiza, die sich von Anfang an als geschlossene Stolonenplatte ausbreitet. (Die Fusion der Stolone zur geschlossenen Platte geschieht normalerweise in einer späteren Phase der Stockentwicklung). Eine Korrelation zwischen den rH-Werten und den besonderen morphogenetischen Einflüssen war nicht zu erkennen. 3. Gemäß diesen „vegetativisierenden“ Einflüssen auf die Metamorphose lösen die applizierten Thiol-Reagenzien bei regenerierenden Polypen die Entwicklung basaler Strukturen und Eigenschaften aus. Während unbehandelte Polypen verlorene basale Teile nicht ergänzen, können nach Behandlung mit Dithioerythrit, Dimercaptopropanol und Diamide Stiele und Stolone auswachsen. Diamide und vor allem Dimercaptopropanol führen jedoch in den meisten Fällen zu einer vollständigen Umdifferenzierung der ganzen Polypen. Ohne ihre äußeres Erscheinungsbild zu ändern, wandeln sie sich in Riesenstolone um, die eine Peridermhülle ausscheiden, Sekundärpolypen knospen und freie Stolone aussprossen lassen. 4. Ähnliche Effekte wurden nach partieller tryptischer Dissoziation des Gewebes beobachtet. Da alle Reagenzien zumindestens in höherer Dosis zur Trennung von Ekto- und Endoderm und zu einer teilweisen Dissoziation führen, wird vermutet, die Verstärkung basaler Entwicklung und die Umpolarisierung des Differenzierungszustandes werde durch eine Änderung der Zellaffinitäten und der Zellmembraneigenschaften verursacht.
    Notes: Summary 1) The influence of reagents affecting SH or SS groups on morphogenesis has been studied in metamorphosing larvae and in regenerating adult hydranths. The thiol challenges evoke and enhance predominantly the differentiation of basal structures. 2) In larvae undergoing metamorphosis the SS-reducing agent Dithioerythrit (0.12–0.25 mM) brings about a prolongation of the subtentacular part of the body column. Dimercaptopropanol (0.19 mM), among other thiol challenges, enhances specifically stolonization giving rise to highly enlarged stolons. Under the influence of the oxidizing Kosower reagent Diamide (0.075–0.15 mM) transforming larvae develop a hypertrophied hydrorhiza which grows as a closed stolon-plate from the outset. In this way the primary polyps prematurely acquire the developmental state of sexual colonies. A correlation between the rH-values and the particular morphogenetic influences could not be established. 3) According to these “vegetalizing” influences on metamorphosis the thiol challenges cause regenerating hydranths to engage, in contrast to untreated controls, in differentiation of basal structures. The hydranths develop, though only in few cases, basal structures (stalks, stolons), whereas basal parts normally are never restored. In most cases, however, Diamide and especially dimercaptopropanol impose stolonial properties on hydranths as a whole. Such hydranths transform into giant stolons and secrete a periderm without first changing their outward appearance. Thus their state of differentiation becomes totally repolarized. 4) Tryptic dissociation exerts similar effects. Since all thiol reagents, at least in high doses, lead to the separation of the ectoderm and endoderm and to a partial dissociation of the tissue, it is suggested that the enhancement of basal development and the repolarization of the state of differentiation might be due to changes in cell adhesiveness and membrane properties.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 13 (1978), S. 55-60 
    ISSN: 1432-1041
    Keywords: Valproic acid ; pharmacokinetics ; liver disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition of valproic acid (di-n-propylacetate; VA) has been studied after a single oral dose of a solution of 450 mg in 7 patients with alcoholic cirrhosis and in 4 patients recovering from acute hepatitis. The diagnosis was based on biochemical function tests and histological findings. The pharmacokinetic parameters were compared with those reported for healthy volunteers. VA in therapeutic concentration (80 µg/ml) in plasma was less bound to plasma proteins in patients with alcoholic cirrhosis (70.7±11.3%) and in patients recovering from acute hepatitis (78.1±14.1%) than in controls (88.7±5.2%). The reduced binding affected the blood/plasma concentration ratio and the apparent distribution volume Vd(β); the latter was increased from the normal value of 0.14±0.05 l/kg to 0.22±0.09 (p〈0.05) in alcoholic cirrhotics, and to 0.20±0.07 (p=0.056) in patients recovering from acute hepatitis. The half-life of elimination T1/2 (β) (controls=12.2±3.7 h) was significantly (p〈0.05) prolonged in cirrhotics (18.9±5.1 h) and in patients recovering from acute hepatitis (17.0±3.7 h). The plasma $$\overline {Cl} $$ of total drug was not impaired, which can best be explained by the lower plasma protein binding, which might have increased the $$\overline {Cl} $$ of this drug which shows restricted clearance. In addition, the plasma $$\overline {Cl} $$ of free drug was significantly (p〈0.02) reduced in alcoholic cirrhotics. During a two day urine collection no measurable amount of unchanged VA was recovered. There was considerable excretion of VA-conjugates, which could be hydrolyzed either by HCl or by β-glucuronidase/arylsulphatase (4–23% of the dose). These percentages were in the same range as in normals (26.7±16.1%). The study indicates that elimination of VA is slightly impaired in patients with dysfunction of the liver.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 45 (1953), S. 2522-2526 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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