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  • 1
    ISSN: 1573-899X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The activity of neurons of the reticular portion of the substantia nigra before and after the microinjection of haloperidol (25 μg/5 μl) into the head of the caudate nucleus on the ipsilateral side was investigated under chronic experimental conditions in cats, using the extracellular microelectrode pickup technique. A significant (p〈0.05) increase, from 34 to 61%, of neurons with the burst type of spontaneous activity was established after the injection of haloperidol. A significant increase in the ratio of the number of excitatory responses to inhibitory responses, from 0.04 to 0.4, was identified among the reactions associated with saccadic eye movements following the microinjection of haloperidol. The number of orienting saccades in response to the visual stimulus decreased against this background from 58 to 37%. The identified changes are regarded as a result of the disinhibition of GABAergic neurons of the reticular portion of the substantia nigra under the influence of the blockade of D2 dopamine receptors of the neostriatum.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Neuroscience and behavioral physiology 16 (1986), S. 506-512 
    ISSN: 1573-899X
    Keywords: subcortical nuclei ; impulse activity ; anodal polarization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The influence of anodal polarization on the spontaneous activity of neurons in the caudate nucleus, medial geniculate body, and the median center of the thalamus and on the evoked impulse activity of neurons in the medial geniculate body was investigated during auditory stimulation. The impulse activity was recorded extracellularly with glass and metallic microelectrodes. Nichrome polarizing electrodes of 0.2 mm diameter with an uninsulated tip of 0.3 mm were inserted into the foregoing structures in a packet. Current parameters evoking the reversible suppression of spontaneous and evoked neuronal activity were determined: 300–500 μA during exposure for 1–3 min at a distance of up to 3 mm from the polarizing electrode. After the cessation of polarization, a prolonged aftereffect was observed: The inhibition of evoked discharges lasted 4–10 min, and the evoked impulse responses disappeared for 5–20 min.
    Type of Medium: Electronic Resource
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