ISSN:
1573-899X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The activity of neurons of the reticular portion of the substantia nigra before and after the microinjection of haloperidol (25 μg/5 μl) into the head of the caudate nucleus on the ipsilateral side was investigated under chronic experimental conditions in cats, using the extracellular microelectrode pickup technique. A significant (p〈0.05) increase, from 34 to 61%, of neurons with the burst type of spontaneous activity was established after the injection of haloperidol. A significant increase in the ratio of the number of excitatory responses to inhibitory responses, from 0.04 to 0.4, was identified among the reactions associated with saccadic eye movements following the microinjection of haloperidol. The number of orienting saccades in response to the visual stimulus decreased against this background from 58 to 37%. The identified changes are regarded as a result of the disinhibition of GABAergic neurons of the reticular portion of the substantia nigra under the influence of the blockade of D2 dopamine receptors of the neostriatum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02359251
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