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  • 1
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    Cambridge University Press
    In:  EPIC3Climate Change 2014: Impacts, Adaptation, and Vulnerability. Part A: Global and Sectoral Aspects. Contribution of Working Group II to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge, United Kingdom and New York, NY, USA, Cambridge University Press, pp. 1-32, ISBN: 9781107641655
    Publication Date: 2015-03-08
    Repository Name: EPIC Alfred Wegener Institut
    Type: Inbook , peerRev
    Format: application/pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular evolution 23 (1986), S. 259-266 
    ISSN: 1432-1432
    Keywords: Experimental evolution ; l-Galactose metabolism ; l-Fucose regulon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary l-Galactose,d-arabinose, andl-fucose form six-membered rings with identical stereoconfigurations. However, onlyl-fucose can serve as the sole carbon and energy source of wild-typeEscherichia coli K-12. A mutant that can grow onl-galactose andd-arabinose was isolated by alternate selection on the two sugars. Thel-fucose pathway became inducible by all three sugars. Transduction into the mutant of the wild-type fuc+ region containing both the regulatory and structural genes abolished the novel growth abilities onl-galactose andd-arabinose, whereas transduction into the mutant of a fuc deletion abolished the growth abilities on all three sugars. Introduction of the wild-type fucR+ (which encodes the activator protein for the fuc regulon) on a multicopy plasmid depressed the growth abilities of the mutant onl-galactose andd-arabinose, but not onl-fucose. The results suggest that the effector specificity of the activator protein in the mutant was broadened. It is proposed that an adaptive response of an activator-controlled system is more likely than that of a repressor-controlled system to achieve fixation in a population, because the first variant to emerge in response to a novel metabolic demand has a good chance of having an altered specificity of regulation. Such a change entails little or no metabolic liability during the absence of the novel substrate. In contrast, the first variant of a negatively controlled system to emerge has an overwhelming chance of being the result of a random mutation that destroys repressor function. Although negatively controlled systems can be more opportunistic in exploiting new conditions than positively controlled systems, an adaptive change is less likely to become fixed because of the cost associated with gratuitous constitutive gene expression in the absence of the substrate.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular evolution 19 (1983), S. 429-436 
    ISSN: 1432-1432
    Keywords: Experimental evolution ; Glycerol dehydrogenase ; Pathway replacement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Wild-typeEscherichia coli utilizes glycerol aerobically through an inducible pathway mediated by an ATP-dependent kinase and a glycerol 3-phosphate dehydrogenase which is a flavoprotein. A mutant, strain ECL424, employing a novel pathway for glycerol utilization was isolated. The novel pathway is mediated by an NAD-linked dehydrogenase and a dihydroxyacetone specific enzyme II of the phosphoenolpyruvate phosphotransferase system. This study describes the selection from strain ECL424, a derivative which grows more rapidly on glycerol. The derivative, strain ECL428, produces twice the parental levels of both the dehydrogenase and the enzyme II during growth on glycerol. The function of the dehydrogenase in wild-type cells is unknown, although hydroxyacetone (acetol), 3-hydroxy-2-butanone (acetoin), and 1-amino-2-propanone are gratuitous inducers. The induction can be prevented by glucose whose effect can be cancelled by external cyclic AMP. The effects of hydroxyacetone, glucose, and cyclic AMP are attenuated in the two mutants in which the dehydrogenase is produced at high basal levels. The dihydroxyacetone specific enzyme II is inducible by the substrate in both wild-type and mutant strains and serves for growth on the triose.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experiments in fluids 20 (1996), S. 401-409 
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Swirling flows in three circular-to-rectangular transition ducts, each of them with an aspect ratio of 2.0 at the rectangular exit, have been studied experimentally. The swirling flows were produced by swirlers whose vane angles were at 5°, 10° and 20° inclinded to the incoming flow, respectively. Flow visualization experiments were made at selected cross-sectional planes in the transition ducts. Pressure and velocity measurements were obtained on the contoured duct walls and at the rectangular exit planes, respectively. The results show that the swirling flow pattern evolves into a skewed structure at the exit plane which, in connection with the wall pressure distributions, is asymmetric with respect to the centerline of either the top and bottom walls or the side walls. Moreover, an analysis based on the mean streamwise vorticity equation with the velocity data obtained immediately downstream of the rectangular exit plane indicates that the cross-stream Reynolds stress plays an important role in transporting the streamwise vorticity of the swirling flow into the surrounding fluid.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 132 (1982), S. 219-224 
    ISSN: 1432-072X
    Keywords: Rhizobium ; Nitrogen fixation ; Nodules ; Soybean
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Several mutants defective in nodulation were isolated from Rhizobium japonicum strains 3I1b110 and 61A 76. Mutants of class I do not form nodules after incubation with soybean [Glycine max (L.) Merrill] for 17 days, but will do so by 28 days. When host plants other than G. max are infected with several of these strains, there is no detectable difference in the time of nodulation or size of nodules as compared to the wild type. Two mutants of class I (i. e., SM1 and SM2) have been shown previously to be altered in the lipopolysaccharide portion of their cell wall. Mutants of class II are not slow to nodulate but form fewer nodules than the wild type on all the host plants tested. Mutants of class III are unable to form nodules. Some bacteriophage-resistant mutants, altered in cell surface structure, fall into this class. Two mutants of class III do not bind to soybean roots.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 17 (1980), S. 425-428 
    ISSN: 1432-1041
    Keywords: prazosin ; congestive heart failure ; pharmacokinetics ; oral dose ; comparison with healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of prazosin (Minipress®) were studied in nine patients with NYHA Class 3 or 4 congestive heart failure and in five healthy controls. After a single 5 mg oral dose, plasma concentrations of prazosin, as reflected in the area under the plasma concentration-time curve (AUC) and prazosin plasma half-life, were approximately double in the patients in comparison to the control group. Reduction in hepatic blood flow, altered gastrointestinal absorption of the drug or diminished intrinsic hepatic metabolic activity in the patient group may have contributed to the observed changes in prazosin disposition. The finding of higher prazosin plasma concentrations in patients with refractory heart failure demonstrates the need for close monitoring of these individuals following administration of the drug in the treatment of chronic congestive heart failure.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Physics of the solid state 42 (2000), S. 1946-1951 
    ISSN: 1063-7834
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The cluster mechanism of diamond synthesis has been proposed. The mechanism is based on the concept of vibrational interactions between objects with the anomalously high Debye temperature. The estimates obtained for the crystal sizes are in good agreement with the experimental data on the dynamic and static syntheses of diamonds from different solid carbon forms such as organic materials, nanodiamonds, fullerite, graphite, and nanotubes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the World Aquaculture Society 25 (1994), S. 0 
    ISSN: 1749-7345
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Three enrichment techniques were evaluated for their efficiency in improving the dietary value of Artemia nauplii to striped bass larvae. Newly hatched Artemia nauplii from the Great Salt Lake (GSL) were enriched for 24 h using the following diets: 1) gelatin-acacia microcapsules containing menhaden oil rich in omega-3 polyunsaturated fatty acids (PUFA), primarily 20:5ω3 eicosapen-taenoic acid; 2) an emulsion of Baker's yeast and menhaden oil; and 3) marine Chlorella sp. Unfed San Francisco Bay (SFB) and GSL nauplii were used as controls. Enriched GSL (all three diets) and unfed SFB nauplii had significantly higher (P 〈 0.05) levels of 20:503 than the unfed nauplii from GSL. Seven days post-hatched (day 0) striped bass larvae were reared for 21 d on enriched or unfed nauplii. On day 21, wet weight and total length of striped bass larvae fed enriched GSL nauplii and unfed SFB nauplii were significantly greater (P 〈 0.05) than those fed unenriched GSL nauplii. The enrichment of the GSL nauplii appeared to increase the eicosapentaenoic acid content and enhance the growth of the striped bass larvae.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 375 (1986), S. 111-118 
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics B (Proceedings Supplements) 6 (1989), S. 425-427 
    ISSN: 0920-5632
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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