ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary As Tyrothricin —Dubos's discovery of the antibiotic agent extracted from cultures ofB. brevis — does not give true aqueous solutions and retains, in the colloïdal state of the usually employed solutions, toxic properties for polymorphonuclear blood cells, we have attempted to effect the solubilization and detoxification of this compound. Treatment with formalin in given proportions results in making it water-soluble. The action of the formalin-treated compound on blood cells suspended in Ringer's solution seems to show a loss of toxicity. Subcutaneous and intramuscular injections in mice do not give visible general toxic effects, and the experiments incite to further investigations in this direction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02163989
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