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  • 1
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    Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium (2011)
    Oxford University Press
    Details
    Publication Date: 2011-09-09
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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    PAPER CURRENT
  • 2
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    Robust assessment of the expansion and retreat of Mediterranean climate in the 21st century (2015)
    Details
    Publication Date: 2017-04-04
    Description: The warm-temperate regions of the globe characterized by dry summers and wet winters (Mediterranean climate; MED) are especially vulnerable to climate change. The potential impact on water resources,ecosystems and human livelihood requires a detailed picture of the future changes in this unique climate zone. Here we apply a probabilistic approach to quantitatively address how and why the geographic distribution of MED will change based on the latest-available climate projections for the 21st century. Our analysis provides, for the first time, a robust assessment of significant northward and eastward future expansions of MED over both the Euro-Mediterranean and western North America. Concurrently, we show a significant 21st century replacement of the equatorward MED margins by the arid climate type.Moreover, future winters will become wetter and summers drier in both the old and newly established MED zones. Should these projections be realized, living conditions in some of the most densely populated regions in the world will be seriously jeopardized.
    Description: Published
    Description: 7211
    Description: 4A. Clima e Oceani
    Description: JCR Journal
    Description: restricted
    Keywords: CMIP5 projections ; Mediterranean climate ; 01. Atmosphere::01.01. Atmosphere::01.01.02. Climate
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
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    Volume change associated with formation and dissociation of hydrate in sediment (2010)
    American Geophysical Union
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2010. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 11 (2010): Q03007, doi:10.1029/2009GC002667.
    Description: Gas hydrate formation and dissociation in sediments are accompanied by changes in the bulk volume of the sediment and can lead to changes in sediment properties, loss of integrity for boreholes, and possibly regional subsidence of the ground surface over areas where methane might be produced from gas hydrate in the future. Experiments on sand, silts, and clay subject to different effective stress and containing different saturations of hydrate formed from dissolved phase tetrahydrofuran are used to systematically investigate the impact of gas hydrate formation and dissociation on bulk sediment volume. Volume changes in low specific surface sediments (i.e., having a rigid sediment skeleton like sand) are much lower than those measured in high specific surface sediments (e.g., clay). Early hydrate formation is accompanied by contraction for all soils and most stress states in part because growing gas hydrate crystals buckle skeletal force chains. Dilation can occur at high hydrate saturations. Hydrate dissociation under drained, zero lateral strain conditions is always associated with some contraction, regardless of soil type, effective stress level, or hydrate saturation. Changes in void ratio during formation-dissociation decrease at high effective stress levels. The volumetric strain during dissociation under zero lateral strain scales with hydrate saturation and sediment compressibility. The volumetric strain during dissociation under high shear is a function of the initial volume average void ratio and the stress-dependent critical state void ratio of the sediment. Other contributions to volume reduction upon hydrate dissociation are related to segregated hydrate in lenses and nodules. For natural gas hydrates, some conditions (e.g., gas production driven by depressurization) might contribute to additional volume reduction by increasing the effective stress.
    Description: This research was initially supported by the Chevron Joint Industry Project on Methane Hydrates under contract DE‐FC26‐01NT41330 from the U.S. Department of Energy to Georgia Tech. Additional support was provided to J. Y. Lee by KIGAM, GHDO, and MKE and J. C. Santamarina by the Goizueta Foundation.
    Keywords: Gas hydrate ; Hydrate-bearing sediment ; Phase transformation ; Strain
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
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    Prediction of Indian summer monsoon onset using dynamical sub-seasonal forecasts: effects of realistic initialization of the atmosphere (2015)
    American Meteorological Society
    Details
    Publication Date: 2021-11-09
    Description: Ensembles of retrospective 2-month dynamical forecasts initiated on 1May are used to predict the onset of the Indian summer monsoon (ISM) for the period 1989–2005. The subseasonal predictions (SSPs) are based on a coupled general circulation model and recently they have been upgraded by the realistic initialization of the atmosphere with initial conditions taken from reanalysis. Two objective large-scale methods based on dynamical circulation and hydrological indices are applied to detect the ISM onset. The SSPs show some skill in forecasting earlier-than-normal ISM onsets, while they have difficulty in predicting late onsets. It is shown that significant contribution to the skill in forecasting early ISM onsets comes from the newly developed initialization of the atmosphere from reanalysis. On one hand, atmospheric initialization produces a better representation of the atmospheric mean state in the initial conditions, leading to a systematically improved monsoon onset sequence. On the other hand, the initialization of the atmosphere allows some skill in forecasting the northward propagating intraseasonal wind and precipitation anomalies over the tropical Indian Ocean. The northward propagating intraseasonal modes trigger the monsoon in some early-onset years. The realistic phase initialization of these modes improves the forecasts of the associated earlier-than-normal monsoon onsets. The prediction of late onsets is not noticeably improved by the initialization of the atmosphere. It is suggested that late onsets of the monsoon are too far away from the start date of the forecasts to conserve enough memory of the intraseasonal oscillation (ISO) anomalies and of the improved representation of the mean state in the initial conditions.
    Description: Published
    Description: 778-793
    Description: 4A. Clima e Oceani
    Description: JCR Journal
    Description: restricted
    Keywords: indian summer monsoon ; onset ; seasonal predictions ; 01. Atmosphere::01.01. Atmosphere::01.01.02. Climate ; 01. Atmosphere::01.01. Atmosphere::01.01.04. Processes and Dynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 5
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    Parametric study of the physical properties of hydrate-bearing sand, silt, and clay sediments : 1. Electromagnetic properties (2010)
    American Geophysical Union
    Details
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2010. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 115 (2010): B11104, doi:10.1029/2009JB006669.
    Description: The marked decrease in bulk electrical conductivity of sediments in the presence of gas hydrates has been used to interpret borehole electrical resistivity logs and, to a lesser extent, the results of controlled source electromagnetic surveys to constrain the spatial distribution and predicted concentration of gas hydrate in natural settings. Until now, an exhaustive laboratory data set that could be used to assess the impact of gas hydrate on the electromagnetic properties of different soils (sand, silt, and clay) at different effective stress and with different saturations of hydrate has been lacking. The laboratory results reported here are obtained using a standard geotechnical cell and the hydrate-formed tetrahydrofuran (THF), a liquid that is fully miscible in water and able to produce closely controlled saturations of hydrate from dissolved phase. Both permittivity and electrical conductivity are good indicators of the volume fraction of free water in the sediment, which is in turn dependent on hydrate saturation. Permittivity in the microwave frequency range is particularly predictive of free water content since it is barely affected by ionic concentration, pore structure, and surface conduction. Electrical conductivity (or resistivity) is less reliable for constraining water content or hydrate saturation: In addition to fluid-filled porosity, other factors, such as the ionic concentration of the pore fluid and possibly other conduction effects (e.g., surface conduction in high specific surface soils having low conductivity pore fluid), also influence electrical conductivity.
    Description: This research was initially supported by the Chevron Joint Industry Project on Methane Hydrates under contract DE‐FC26‐01NT41330 from the U.S. Department of Energy. Additional support was provided to J.C.S. by the Goizueta Foundation at Georgia Tech, to J.Y.L. by KIGAM, and to C. Ruppel by the USGS.
    Keywords: Gas hydrate ; Electromagnetic properties ; Resistivity
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 6
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    Parametric study of the physical properties of hydrate-bearing sand, silt, and clay sediments : 2. Small-strain mechanical properties (2010)
    American Geophysical Union
    Details
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2010. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 115 (2010): B11105, doi:10.1029/2009JB006670.
    Description: The small-strain mechanical properties (e.g., seismic velocities) of hydrate-bearing sediments measured under laboratory conditions provide reference values for calibration of logging and seismic exploration results acquired in hydrate-bearing formations. Instrumented cells were designed for measuring the compressional (P) and shear (S) velocities of sand, silts, and clay with and without hydrate and subject to vertical effective stresses of 0.01 to 2 MPa. Tetrahydrofuran (THF), which is fully miscible in water, was used as the hydrate former to permit close control over the hydrate saturation Shyd and to produce hydrate from dissolved phase, as methane hydrate forms in most natural marine settings. The results demonstrate that laboratory hydrate formation technique controls the pattern of P and S velocity changes with increasing Shyd and that the small-strain properties of hydrate-bearing sediments are governed by effective stress, σ′v and sediment specific surface. The S velocity increases with hydrate saturation owing to an increase in skeletal shear stiffness, particularly when hydrate saturation exceeds Shyd≈ 0.4. At very high hydrate saturations, the small strain shear stiffness is determined by the presence of hydrates and becomes insensitive to changes in effective stress. The P velocity increases with hydrate saturation due to the increases in both the shear modulus of the skeleton and the bulk modulus of pore-filling phases during fluid-to-hydrate conversion. Small-strain Poisson's ratio varies from 0.5 in soft sediments lacking hydrates to 0.25 in stiff sediments (i.e., subject to high vertical effective stress or having high Shyd). At Shyd ≥ 0.5, hydrate hinders expansion and the loss of sediment stiffness during reduction of vertical effective stress, meaning that hydrate-rich natural sediments obtained through pressure coring should retain their in situ fabric for some time after core retrieval if the cores are maintained within the hydrate stability field.
    Description: Initial support for this research to J.C.S. and C.R. at Georgia Tech was provided by the Chevron Joint Industry Project on Methane Hydrates under contract DE‐FC26‐01NT41330 from the U.S. Department of Energy. Additional support to J.C.S. was provided by the Goizueta Foundation at Georgia Tech and to J.Y.L. by KIGAM, GHDO, and MKE.
    Keywords: Gas hydrate ; Mechanical properties ; Seismic velocity
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 7
    Electronic Resource
    Electronic Resource
    Histidine Complexes of Molybdenum(V) and Molybdenum(VI) (1965)
    s.l. : American Chemical Society
    Inorganic chemistry 4 (1965), S. 385-388 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50025a028
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray analysis of chicken-liver glutathione S-transferase CL 3-3 (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 601-603 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Five different crystal forms of recombinant chicken-liver glutathione S-transferase CL 3-3 have been obtained by the vapor-diffusion method. The form A crystals are monoclinic C2, a = 125.56, b = 85.81, c = 52.71 Å and β = 114.64°, and diffract to 4 Å resolution. The form B crystals are monoclinic P21, a = 105.13, b = 118.54, c = 62.62 Å and β = 124.74°, and diffract to 2.8 Å resolution. The form C crystals are orthorhombic C222l, a = 101.69, b = 115.46, c = 95.40 Å, and diffract to 2.8 Å resolution. The form D crystals are tetragonal, P41212 or P43212, a = b = 115.31, c = 171.20 Å and diffract to 3.5 Å resolution. The form E crystals are hexagonal, P61 or P65, a = b = 104.23, c = 114.35 Å, diffract to 3.5 Å resolution. Forms A, C and E have one dimer of molecular weight 50 kDa, while forms B and D have two dimers per asymmetric unit, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995016866
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  • 9
    Electronic Resource
    Electronic Resource
    Protein Stability of Frozen Milk as Influenced by Storage Temperature and Ultrafiltration (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 46 (1981), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Milk and milk concentrates containing 12–35% total solids were stored at 0, –2, –4, –6, –8, –12, and –20°C and protein stability of the thawed products was evaluated periodically. Samples stored at –4 to – 12°C exhibited poorer protein stability than samples stored at higher or lower temperatures. Ultrafiltered (UF) skimmilk with permeate: retentate ratios of 10:90, 20:80, and 30:70 were stored at –8°C and they remained stable at least three times longer than frozen control samples of UF skimmilk stored at the same temperature. When the extent of UF was increased to 40:60, protein stability in the frozen retentate declined somewhat as compared to that of less concentrated retentates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1981.tb03025.x
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  • 10
    Electronic Resource
    Electronic Resource
    Two-stage Nested PCR Effectiveness for Direct Detection of Vibrio vulnificus in Natural Samples (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 64 (1999), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The nested primers designed to amplify a 222-base pair portion of the hemolysin gene, vvhA, were specific for all V. vulnificus strains tested. The nested PCR amplification, coupled with direct extraction of template DNA, revealed improved sensitivity sufficient for detection of 1 to 10 CFU V. vulnificus in 1 mL of seafood homogenates, and eliminated the need for enrichment culturing. Thereby, the nested PCR method achieved a broader applicability, making it effective for extensive use in identification of the pathogen in natural samples such as raw seafoods, seawater and sediments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1999.tb09882.x
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