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  • 1
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    Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-09-27
    Description: The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha+ dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allan, Rhys S -- Smith, Chris M -- Belz, Gabrielle T -- van Lint, Allison L -- Wakim, Linda M -- Heath, William R -- Carbone, Francis R -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1925-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512632" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation ; Antigens, CD/analysis ; Antigens, CD8/*analysis ; Antigens, Viral/immunology ; Cell Separation ; Chimera ; Cytotoxicity, Immunologic ; Dendritic Cells/*immunology ; Epidermis/*immunology ; H-2 Antigens/analysis/immunology ; Herpes Simplex/*immunology ; Herpesvirus 1, Human/*immunology ; Histocompatibility Antigens Class II/analysis ; Langerhans Cells/*immunology ; Lectins, C-Type/analysis ; Lymph Nodes/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Transgenic ; Receptors, Cell Surface/analysis ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Envelope Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-04-02
    Description: After an infection, cytotoxic T lymphocyte precursors proliferate and become effector cells by recognizing foreign peptides in the groove of major histocompatibility complex (MHC) class I molecules expressed by antigen-presenting cells (APCs). Professional APCs specialized for T-cell activation acquire viral antigen either by becoming infected themselves (direct presentation) or by phagocytosis of infected cells, followed by transfer of antigen to the cytosol, processing and MHC class I loading in a process referred to as cross-presentation. An alternative way, referred to as 'cross-dressing', by which an uninfected APC could present antigen was postulated to be by the transfer of preformed peptide-MHC complexes from the surface of an infected cell to the APC without the need of further processing. Here we show that this mechanism exists and boosts the antiviral response of mouse memory CD8(+) T cells. A number of publications have demonstrated sharing of peptide-loaded MHC molecules in vitro. Our in vitro experiments demonstrate that cross-dressing APCs do not acquire peptide-MHC complexes in the form of exosomes released by donor cells. Rather, the APCs and donor cells have to contact each other for the transfer to occur. After a viral infection, we could isolate cross-dressed APCs able to present viral antigen in vitro. Furthermore, using the diphtheria toxin system to selectively eliminate APCs that could only acquire viral peptide-MHC complexes by cross-dressing, we show that such presentation can promote the expansion of resting memory T cells. Notably, naive T cells were excluded from taking part in the response. Cross-dressing is a mechanism of antigen presentation used by dendritic cells that may have a significant role in activating previously primed CD8(+) T cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423191/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423191/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wakim, Linda M -- Bevan, Michael J -- R01 AI019335/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2011 Mar 31;471(7340):629-32. doi: 10.1038/nature09863.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21455179" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation/*immunology ; Antigens, Viral/immunology ; CD8-Positive T-Lymphocytes/cytology/*immunology ; Cell Adhesion ; Cell Proliferation ; Cells, Cultured ; Dendritic Cells/cytology/*immunology/metabolism ; Diphtheria Toxin ; Exosomes ; Female ; H-2 Antigens/immunology/metabolism ; Immunologic Memory/*immunology ; Immunological Synapses ; Lymphocyte Activation/*immunology ; Lymphocytic choriomeningitis virus/immunology/physiology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; *Models, Immunological ; Protein Transport ; Vesiculovirus/immunology/physiology ; Virus Diseases/*immunology/virology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Dendritic cell-induced memory T cell activation in nonlymphoid tissues (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-01-12
    Description: Secondary lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen-presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue-resident T cells during secondary challenge. The results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wakim, Linda M -- Waithman, Jason -- van Rooijen, Nico -- Heath, William R -- Carbone, Francis R -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):198-202. doi: 10.1126/science.1151869.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187654" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation ; CD8-Positive T-Lymphocytes/*immunology ; Dendritic Cells/*immunology ; Female ; Ganglia, Spinal/*immunology/transplantation/virology ; Herpes Simplex/*immunology/virology ; Herpesvirus 1, Human/*immunology/physiology ; *Immunologic Memory ; *Lymphocyte Activation ; Lymphocyte Count ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Viral Envelope Proteins/immunology ; Virus Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence (2010)
    National Academy of Sciences
    Details
    Publication Date: 2010-10-05
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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