Publication Date:
1998-01-31
Description:
Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, H -- Ivic, L -- Otaki, J M -- Hashimoto, M -- Mikoshiba, K -- Firestein, S -- New York, N.Y. -- Science. 1998 Jan 9;279(5348):237-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9422698" target="_blank"〉PubMed〈/a〉
Keywords:
Adenoviridae/genetics/physiology
;
Aldehydes/metabolism/*pharmacology
;
Animals
;
Electrophysiology
;
Female
;
Gene Expression
;
Genetic Vectors
;
Green Fluorescent Proteins
;
Luminescent Proteins/analysis/genetics
;
Male
;
*Odors
;
Olfactory Receptor Neurons/*physiology/virology
;
Patch-Clamp Techniques
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Odorant/genetics/metabolism/*physiology
;
Recombinant Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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