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  • 1
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    First Direct Measurements of Superheavy-Element Mass Numbers (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-11-29
    Description: Author(s): J. M. Gates, G. K. Pang, J. L. Pore, K. E. Gregorich, J. T. Kwarsick, G. Savard, N. E. Esker, M. Kireeff Covo, M. J. Mogannam, J. C. Batchelder, D. L. Bleuel, R. M. Clark, H. L. Crawford, P. Fallon, K. K. Hubbard, A. M. Hurst, I. T. Kolaja, A. O. Macchiavelli, C. Morse, R. Orford, L. Phair, and M. A. Stoyer A new measurement technique directly determines the masses of two superheavy isotopes, providing confirmation that previous indirect measurements were correct. [Phys. Rev. Lett. 121, 222501] Published Wed Nov 28, 2018
    Keywords: Nuclear Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Broad phylogenomic sampling improves resolution of the animal tree of life (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-03-07
    Description: Long-held ideas regarding the evolutionary relationships among animals have recently been upended by sometimes controversial hypotheses based largely on insights from molecular data. These new hypotheses include a clade of moulting animals (Ecdysozoa) and the close relationship of the lophophorates to molluscs and annelids (Lophotrochozoa). Many relationships remain disputed, including those that are required to polarize key features of character evolution, and support for deep nodes is often low. Phylogenomic approaches, which use data from many genes, have shown promise for resolving deep animal relationships, but are hindered by a lack of data from many important groups. Here we report a total of 39.9 Mb of expressed sequence tags from 29 animals belonging to 21 phyla, including 11 phyla previously lacking genomic or expressed-sequence-tag data. Analysed in combination with existing sequences, our data reinforce several previously identified clades that split deeply in the animal tree (including Protostomia, Ecdysozoa and Lophotrochozoa), unambiguously resolve multiple long-standing issues for which there was strong conflicting support in earlier studies with less data (such as velvet worms rather than tardigrades as the sister group of arthropods), and provide molecular support for the monophyly of molluscs, a group long recognized by morphologists. In addition, we find strong support for several new hypotheses. These include a clade that unites annelids (including sipunculans and echiurans) with nemerteans, phoronids and brachiopods, molluscs as sister to that assemblage, and the placement of ctenophores as the earliest diverging extant multicellular animals. A single origin of spiral cleavage (with subsequent losses) is inferred from well-supported nodes. Many relationships between a stable subset of taxa find strong support, and a diminishing number of lineages remain recalcitrant to placement on the tree.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, Casey W -- Hejnol, Andreas -- Matus, David Q -- Pang, Kevin -- Browne, William E -- Smith, Stephen A -- Seaver, Elaine -- Rouse, Greg W -- Obst, Matthias -- Edgecombe, Gregory D -- Sorensen, Martin V -- Haddock, Steven H D -- Schmidt-Rhaesa, Andreas -- Okusu, Akiko -- Kristensen, Reinhardt Mobjerg -- Wheeler, Ward C -- Martindale, Mark Q -- Giribet, Gonzalo -- England -- Nature. 2008 Apr 10;452(7188):745-9. doi: 10.1038/nature06614. Epub 2008 Mar 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Kewalo Marine Laboratory, PBRC, University of Hawaii, 41 Ahui Street, Honolulu, Hawaii 96813, USA. casey_dunn@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18322464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bayes Theorem ; Classification/*methods ; Computational Biology ; Databases, Genetic ; Evolution, Molecular ; Expressed Sequence Tags ; Gene Library ; Humans ; Markov Chains ; *Phylogeny ; Reproducibility of Results ; Sample Size ; Sensitivity and Specificity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-18
    Description: An understanding of ctenophore biology is critical for reconstructing events that occurred early in animal evolution. Toward this goal, we have sequenced, assembled, and annotated the genome of the ctenophore Mnemiopsis leidyi. Our phylogenomic analyses of both amino acid positions and gene content suggest that ctenophores rather than sponges are the sister lineage to all other animals. Mnemiopsis lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types evolved independently. The set of neural genes in Mnemiopsis is similar to that of sponges, indicating that sponges may have lost a nervous system. These results present a newly supported view of early animal evolution that accounts for major losses and/or gains of sophisticated cell types, including nerve and muscle cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920664/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920664/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryan, Joseph F -- Pang, Kevin -- Schnitzler, Christine E -- Nguyen, Anh-Dao -- Moreland, R Travis -- Simmons, David K -- Koch, Bernard J -- Francis, Warren R -- Havlak, Paul -- NISC Comparative Sequencing Program -- Smith, Stephen A -- Putnam, Nicholas H -- Haddock, Steven H D -- Dunn, Casey W -- Wolfsberg, Tyra G -- Mullikin, James C -- Martindale, Mark Q -- Baxevanis, Andreas D -- ZIA HG000140-13/Intramural NIH HHS/ -- ZIA HG000140-14/Intramural NIH HHS/ -- ZIA HG000140-15/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1242592. doi: 10.1126/science.1242592.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genome Technology Branch, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24337300" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Biological Evolution ; Cell Lineage/*genetics ; Ctenophora/classification/*cytology/*genetics ; *Genome ; Mesoderm/cytology ; Molecular Sequence Data ; Muscle Development/genetics ; Neurogenesis/genetics ; Phylogeny
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Origins of bilateral symmetry: Hox and dpp expression in a sea anemone (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-08
    Description: Over 99% of modern animals are members of the evolutionary lineage Bilateria. The evolutionary success of Bilateria is credited partly to the origin of bilateral symmetry. Although animals of the phylum Cnidaria are not within the Bilateria, some representatives, such as the sea anemone Nematostella vectensis, exhibit bilateral symmetry. We show that Nematostella uses homologous genes to achieve bilateral symmetry: Multiple Hox genes are expressed in a staggered fashion along its primary body axis, and the transforming growth factor-beta gene decapentaplegic (dpp) is expressed in an asymmetric fashion about its secondary body axis. These data suggest that bilateral symmetry arose before the evolutionary split of Cnidaria and Bilateria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finnerty, John R -- Pang, Kevin -- Burton, Pat -- Paulson, Dave -- Martindale, Mark Q -- New York, N.Y. -- Science. 2004 May 28;304(5675):1335-7. Epub 2004 May 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15131263" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Body Patterning ; Endoderm/physiology ; Gene Duplication ; Gene Expression Profiling ; *Gene Expression Regulation, Developmental ; Genes ; *Genes, Homeobox ; In Situ Hybridization ; Larva/genetics/growth & development ; Molecular Sequence Data ; Phylogeny ; Sea Anemones/*anatomy & histology/embryology/*genetics/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Cell differentiation and germ-soma separation in Ediacaran animal embryo-like fossils (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-09-26
    Description: Phosphorites of the Ediacaran Doushantuo Formation ( approximately 600 million years old) yield spheroidal microfossils with a palintomic cell cleavage pattern. These fossils have been variously interpreted as sulphur-oxidizing bacteria, unicellular protists, mesomycetozoean-like holozoans, green algae akin to Volvox, and blastula embryos of early metazoans or bilaterian animals. However, their complete life cycle is unknown and it is uncertain whether they had a cellularly differentiated ontogenetic stage, making it difficult to test their various phylogenetic interpretations. Here we describe new spheroidal fossils from black phosphorites of the Doushantuo Formation that have been overlooked in previous studies. These fossils represent later developmental stages of previously published blastula-like fossils, and they show evidence for cell differentiation, germ-soma separation, and programmed cell death. Their complex multicellularity is inconsistent with a phylogenetic affinity with bacteria, unicellular protists, or mesomycetozoean-like holozoans. Available evidence also indicates that the Doushantuo fossils are unlikely crown-group animals or volvocine green algae. We conclude that an affinity with cellularly differentiated multicellular eukaryotes, including stem-group animals or algae, is likely but more data are needed to constrain further the exact phylogenetic affinity of the Doushantuo fossils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Lei -- Xiao, Shuhai -- Pang, Ke -- Zhou, Chuanming -- Yuan, Xunlai -- England -- Nature. 2014 Dec 11;516(7530):238-41. doi: 10.1038/nature13766. Epub 2014 Sep 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] State Key Laboratory of Palaeobiology and Stratigraphy, and Key Laboratory of Economic Stratigraphy and Palaeogeography, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China [2] College of Earth Science, University of Chinese Academy of Sciences, Beijing 100049, China. ; Department of Geosciences, Virginia Tech, Blacksburg, Virginia 24061, USA. ; State Key Laboratory of Palaeobiology and Stratigraphy, and Key Laboratory of Economic Stratigraphy and Palaeogeography, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China. ; 1] State Key Laboratory of Palaeobiology and Stratigraphy, and Key Laboratory of Economic Stratigraphy and Palaeogeography, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China [2] Department of Geology, Northwest University, Xi'an 710069, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25252979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Blastula/cytology ; *Cell Differentiation ; China ; Chlorophyta/cytology ; Embryo, Nonmammalian/*cytology ; Eukaryotic Cells/classification/cytology ; *Fossils ; *Phylogeny
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-04-23
    Description: Influenza A virus (IAV) causes up to half a million deaths worldwide annually, 90% of which occur in older adults. We show that IAV-infected monocytes from older humans have impaired antiviral interferon production but retain intact inflammasome responses. To understand the in vivo consequence, we used mice expressing a functional Mx gene encoding a major interferon-induced effector against IAV in humans. In Mx1-intact mice with weakened resistance due to deficiencies in Mavs and Tlr7, we found an elevated respiratory bacterial burden. Notably, mortality in the absence of Mavs and Tlr7 was independent of viral load or MyD88-dependent signaling but dependent on bacterial burden, caspase-1/11, and neutrophil-dependent tissue damage. Therefore, in the context of weakened antiviral resistance, vulnerability to IAV disease is a function of caspase-dependent pathology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pillai, Padmini S -- Molony, Ryan D -- Martinod, Kimberly -- Dong, Huiping -- Pang, Iris K -- Tal, Michal C -- Solis, Angel G -- Bielecki, Piotr -- Mohanty, Subhasis -- Trentalange, Mark -- Homer, Robert J -- Flavell, Richard A -- Wagner, Denisa D -- Montgomery, Ruth R -- Shaw, Albert C -- Staeheli, Peter -- Iwasaki, Akiko -- 5T32HL066987-13/HL/NHLBI NIH HHS/ -- AI062428/AI/NIAID NIH HHS/ -- AI064705/AI/NIAID NIH HHS/ -- AI081884/AI/NIAID NIH HHS/ -- F31 AG039163/AG/NIA NIH HHS/ -- HHSN272201100019C/PHS HHS/ -- K24 AG02489/AG/NIA NIH HHS/ -- K24 AG042489/AG/NIA NIH HHS/ -- N01 AI500031/AI/NIAID NIH HHS/ -- P30 AG21342/AG/NIA NIH HHS/ -- R01HL102101/HL/NHLBI NIH HHS/ -- R01HL125501/HL/NHLBI NIH HHS/ -- T32 AI007019-36/AI/NIAID NIH HHS/ -- T32 AI007019-38/AI/NIAID NIH HHS/ -- T32 AI055403/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Apr 22;352(6284):463-6. doi: 10.1126/science.aaf3926.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. ; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. ; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA. ; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA. ; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA. ; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06520, USA. ; Section of Rheumatology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA. ; Institut fur Medizinische Mikrobiologie und Hygiene, Institute of Virology, University Medical Center Freiburg, Hermann-Herder-Strasse 11, 79104 Freiburg, Germany. ; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06520, USA. akiko.iwasaki@yale.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27102485" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/genetics/metabolism ; Adult ; Aged ; Aged, 80 and over ; Animals ; Bacterial Infections/etiology/*immunology ; Caspase 1/metabolism ; Caspases/metabolism ; Female ; Humans ; Immunity, Innate/genetics/*immunology ; Influenza A virus/*immunology ; Influenza, Human/complications/*immunology ; Interferon-beta/immunology ; Male ; Membrane Glycoproteins/genetics/metabolism ; Mice ; Monocytes/immunology ; Myxovirus Resistance Proteins/genetics/*physiology ; Neutrophils/immunology ; Orthomyxoviridae Infections/*immunology ; Respiratory Tract Infections/*immunology/microbiology ; Toll-Like Receptor 7/genetics/metabolism ; Viral Load ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 7
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    Multicolor observations of phobos with the viking lander cameras: evidence for a carbonaceous chondritic composition (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: The reflectivity of Phobos has been determined in the spectral region from 0.4 to 1.1 micrometers from images taken with a Viking lander camera. The reflectivity curve is flat in this spectral interval and the geometric albedo equals 0.05 +/- 0.01. These results, together with Phobos's reflectivity spectrum in the ultraviolet, are compared with laboratory spectra of carbonaceous chondrites and basalts. The spectra of carbonaceous chondrites are consistent with the observations, whereas the basalt spectra are not. These findings raise the possibility that Phobos may be a captured object rather than a natural satellite of Mars.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollack, J B -- Veverka, J -- Pang, K -- Colburn, D -- Lane, A L -- Ajello, J M -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):66-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17841956" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Parathyroid hormone: a coronary artery vasodilator (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-07
    Description: Injection of synthetic bovine parathyroid hormone (the amino terminal peptide containing the first 34 amino acids) to the coronary circulation of the dog resulted in a marked coronary vasodilation. The vasodilatory response was dose-dependent and amounted to a 161 percent increase over the resting flow rate at a concentration of 1.0 unit per kilogram.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crass, M F 3rd -- Pang, P K -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coronary Circulation/*drug effects ; Dogs ; Hormones/pharmacology ; Myocardial Contraction/drug effects ; Myocardium/metabolism ; Oxygen Consumption/drug effects ; Parathyroid Hormone/*pharmacology ; Time Factors ; Vascular Resistance/drug effects ; *Vasodilator Agents
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawyer, W H -- Pang, P K -- Seto, J -- McEnroe, M -- Lammek, B -- Manning, M -- AM 01940/AM/NIADDK NIH HHS/ -- GM 25280/GM/NIGMS NIH HHS/ -- HL 12738/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):49-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209515" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine Vasopressin/*analogs & derivatives/chemical synthesis/pharmacology ; Diuresis/*drug effects ; Female ; Osmolar Concentration ; Rats ; Structure-Activity Relationship ; Vasopressins/*antagonists & inhibitors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 10
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    Redox reactions of small organic molecules using ball milling and piezoelectric materials (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Over the past decade, photoredox catalysis has harnessed light energy to accelerate bond-forming reactions. We postulated that a complementary method for the redox-activation of small organic molecules in response to applied mechanical energy could be developed through the piezoelectric effect. Here, we report that agitation of piezoelectric materials via ball milling reduces aryl diazonium salts. This mechanoredox system can be applied to arylation and borylation reactions under mechanochemical conditions.〈/p〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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