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  • 1
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    CNS synaptogenesis promoted by glia-derived cholesterol (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-10
    Description: The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS) are poorly understood. Previous reports showed that a glia-derived factor strongly promotes synapse development in cultures of purified CNS neurons. Here, we identify this factor as cholesterol complexed to apolipoprotein E-containing lipoproteins. CNS neurons produce enough cholesterol to survive and grow, but the formation of numerous mature synapses demands additional amounts that must be provided by glia. Thus, the availability of cholesterol appears to limit synapse development. This may explain the delayed onset of CNS synaptogenesis after glia differentiation and neurobehavioral manifestations of defects in cholesterol or lipoprotein homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauch, D H -- Nagler, K -- Schumacher, S -- Goritz, C -- Muller, E C -- Otto, A -- Pfrieger, F W -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1354-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Synapse Group and, Protein Chemistry Group, Max-Delbruck-Center for Molecular Medicine, D-13092 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11701931" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anticholesteremic Agents/pharmacology ; Apolipoproteins E/metabolism ; Cells, Cultured ; Cholesterol/*metabolism/pharmacology ; Culture Media, Conditioned ; Excitatory Postsynaptic Potentials ; Lovastatin/*analogs & derivatives/pharmacology ; Neuroglia/*metabolism ; Patch-Clamp Techniques ; Phosphatidylcholines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/metabolism/*physiology ; Sphingomyelins/pharmacology ; Synapses/drug effects/*physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Identification of a conserved 5'-dRP lyase activity in bacterial DNA repair ligase D and its potential role in base excision repair (2016)
    Oxford University Press
    Details
    Publication Date: 2016-03-01
    Description: Bacillus subtilis is one of the bacterial members provided with a nonhomologous end joining (NHEJ) system constituted by the DNA-binding Ku homodimer that recruits the ATP-dependent DNA Ligase D ( Bsu LigD) to the double-stranded DNA breaks (DSBs) ends. Bsu LigD has inherent polymerization and ligase activities that allow it to fill the short gaps that can arise after realignment of the broken ends and to seal the resulting nicks, contributing to genome stability during the stationary phase and germination of spores. Here we show that Bsu LigD also has an intrinsic 5'-2-deoxyribose-5-phosphate (dRP) lyase activity located at the N-terminal ligase domain that in coordination with the polymerization and ligase activities allows efficient repairing of 2'-deoxyuridine-containing DNA in an in vitro reconstituted Base Excision Repair (BER) reaction. The requirement of a polymerization, a dRP removal and a final sealing step in BER, together with the joint participation of Bsu LigD with the spore specific AP endonuclease in conferring spore resistance to ultrahigh vacuum desiccation suggest that Bsu LigD could actively participate in this pathway. We demonstrate the presence of the dRP lyase activity also in the homolog protein from the distantly related bacterium Pseudomonas aeruginosa , allowing us to expand our results to other bacterial LigDs.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Experiment S006: Synoptic weather photography (1971)
    In:  CASI
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    Publication Date: 2005-11-30
    Description: A data gathering effort on a number of cloud systems is reported. On both manned and unmanned Mercury and Gemini 3 missions, a number of good pictures of cloud systems were obtained. Also, specific experiments were performed by the crewmembers in the Mercury missions. Those experiments involved some of the spectral reflectance characteristics of clouds, land, and water regions of the earth surface as viewed from outside the atmosphere. Pictures obtained on successive revolutions of a Gemini spacecraft were indicative of the changes in and the movements of clouds at approximately 90-min intervals at certain points beneath the track of the spacecraft. A series of such views explain the various meteorological phenomena.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Manned Spacecraft Center The Gemini Program: Phys. Sci. Expt. Sum.; p 383-414
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  • 4
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    Experiment S-6, synoptic weather photography (1966)
    In:  CASI
    Details
    Publication Date: 2006-10-26
    Description: High-resolution color photographs of clouds taken in weather photography experiment during Gemini missions
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
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  • 5
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    Experiment S006 /S-6/, synoptic weather photography (1967)
    In:  CASI
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    Publication Date: 2006-01-29
    Description: Synoptic color photography of earth cloud cover during Gemini 10 flight
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. MANNED SPACECRAFT CENTER MANNED SPACEFLIGHT EXPT. GEMINI 10 MISSION MAR. 1967 (SEE N67-14150 05-30)
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  • 6
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    Experiment s-6, synoptic weather photography during gemini iv (1965)
    In:  Other Sources
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    Publication Date: 2011-08-10
    Description: Gemini IV synoptic weather photography - cloud systems and meteorological phenomena
    Keywords: SPACE SCIENCES
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  • 7
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    Weather support for the Earth Resources Technology Satellite (1974)
    In:  Other Sources
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    Publication Date: 2019-07-13
    Description: The operational plans for ERTS include cloud-cover forecasting as a means of preventing the limited lifetime of the spacecraft's tape recorder to be used up on useless imagery. Each day, a forecast of the cloud cover is prepared for all land areas beneath the satellite's track and some adjacent ocean areas for each of the next day's 14 passes. The forecasts are transmitted by facsimile to the ERTS Operations Control Center at 4:00 p.m. each day, where they are used to plan the next day's operations. The forecasting techniques employed are described.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Conference on Aerospace and Aeronautical Meteorology; Nov 12, 1974 - Nov 15, 1974; El Paso, TX
    Format: text
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