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  • 1
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    RA-STRA8 and competence regulate spermatogenesis [Developmental Biology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-05-06
    Description: Mammalian spermatogenesis—the transformation of stem cells into millions of haploid spermatozoa—is elaborately organized in time and space. We explored the underlying regulatory mechanisms by genetically and chemically perturbing spermatogenesis in vivo, focusing on spermatogonial differentiation, which begins a series of amplifying divisions, and meiotic initiation, which ends these divisions. We...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin (2015)
    Oxford University Press
    Details
    Publication Date: 2015-01-10
    Description: High-throughput sequencing reveals an abundance of microRNA-sized fragments derived from larger non-coding RNAs. Roles for these small RNAs in gene silencing are suggested by their co-precipitation with Argonaute, the microRNA effector protein, though the extent to which they suppress gene expression endogenously remains unclear. To address this, we used luciferase reporters to determine the endogenous functionality of small RNAs from a diverse range of sources. We demonstrate small RNAs derived from snoRNAs have the capacity to act in a microRNA-like manner, though we note the vast majority of these are bound to Argonaute at levels below that required for detectable silencing activity. We show Argonaute exhibits a high degree of selectivity for the small RNAs with which it interacts and note that measuring Argonaute-associated levels is a better indicator of function than measuring total expression. Although binding to Argonaute at sufficient levels is necessary for demonstrating microRNA functionality in our reporter assay, this alone is not enough as some small RNAs derived from other non-coding RNAs (tRNAs, rRNAs, Y-RNAs) are associated with Argonaute at very high levels yet do not serve microRNA-like roles.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Magnetic Field and Plasma Observations at Mars: Initial Results of the Mars Global Surveyor Mission (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-03-13
    Description: The magnetometer and electron reflectometer investigation (MAG/ER) on the Mars Global Surveyor spacecraft has obtained magnetic field and plasma observations throughout the near-Mars environment, from beyond the influence of Mars to just above the surface (at an altitude of approximately 100 kilometers). The solar wind interaction with Mars is in many ways similar to that at Venus and at an active comet, that is, primarily an ionospheric-atmospheric interaction. No significant planetary magnetic field of global scale has been detected to date (〈2 x 10(21) Gauss-cubic centimeter), but here the discovery of multiple magnetic anomalies of small spatial scale in the crust of Mars is reported.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Acuna -- Connerney -- Wasilewski -- Lin -- Anderson -- Carlson -- McFadden -- Curtis -- Mitchell -- Reme -- Mazelle -- Sauvaud -- d'Uston -- Cros -- Medale -- Bauer -- Cloutier -- Mayhew -- Winterhalter -- Ness -- New York, N.Y. -- Science. 1998 Mar 13;279(5357):1676-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉M. H. Acuna, J. E. P. Connerney, P. Wasilewski, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. R. P. Lin, Space Sciences Laboratory and Department of Physics, University of California, Berkeley, CA 94720, USA. K. A. Anderson, C. W. Carlson, J. McFadden, D. W. Curtis, D. Mitchell, Space Sciences Laboratory, University of California, Berkeley, CA 94720, USA. H. Reme, C. Mazelle, J. A. Sauvaud, C. d'Uston, A. Cros, J. L. Medale, Centre d'Etude Spatiale des Rayonnements, 31209 Toulouse Cedex, France. S. J. Bauer, University of Graz and Space Research Institute, A-8010 Graz, Austria. P. Cloutier, Department of Space Physics and Astronomy, Rice University, Houston, TX 77005, USA. M. Mayhew, National Science Foundation, Arlington, VA 22230, USA. D. Winterhalter, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. N. F. Ness, Bartol Research Institute, University of Delaware, Newark, DE 19716, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9497279" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Global distribution of crustal magnetization discovered by the mars global surveyor MAG/ER experiment (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-04-30
    Description: Vector magnetic field observations of the martian crust were acquired by the Mars Global Surveyor (MGS) magnetic field experiment/electron reflectometer (MAG/ER) during the aerobraking and science phasing orbits, at altitudes between approximately 100 and 200 kilometers. Magnetic field sources of multiple scales, strength, and geometry were observed. There is a correlation between the location of the sources and the ancient cratered terrain of the martian highlands. The absence of crustal magnetism near large impact basins such as Hellas and Argyre implies cessation of internal dynamo action during the early Naochian epoch ( approximately 4 billion years ago). Sources with equivalent magnetic moments as large as 1.3 x 10(17) ampere-meter2 in the Terra Sirenum region contribute to the development of an asymmetrical, time-variable obstacle to solar wind flow around Mars.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Acuna -- Connerney -- Ness -- Lin -- Mitchell -- Carlson -- McFadden -- Anderson -- Reme -- Mazelle -- Vignes -- Wasilewski -- Cloutier -- New York, N.Y. -- Science. 1999 Apr 30;284(5415):790-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. Bartol Research Institute, University of Delaware, Newark, DE 19716, USA. Space Sciences Laboratory, University of California, Berkeley, CA 94720, USA. Centre d'Etude Spatiale des Rayonn.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10221908" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Lunar surface magnetic fields and their interaction with the solar wind: results from lunar prospector (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-04
    Description: The magnetometer and electron reflectometer experiment on the Lunar Prospector spacecraft has obtained maps of lunar crustal magnetic fields and observed the interaction between the solar wind and regions of strong crustal magnetic fields at high selenographic latitude (30 degreesS to 80 degreesS) and low ( approximately 100 kilometers) altitude. Electron reflection maps of the regions antipodal to the Imbrium and Serenitatis impact basins, extending to 80 degreesS latitude, show that crustal magnetic fields fill most of the antipodal zones of those basins. This finding provides further evidence for the hypothesis that basin-forming impacts result in magnetization of the lunar crust at their antipodes. The crustal magnetic fields of the Imbrium antipode region are strong enough to deflect the solar wind and form a miniature (100 to several hundred kilometers across) magnetosphere, magnetosheath, and bow shock system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin -- Mitchell -- Curtis -- Anderson -- Carlson -- McFadden -- Acuna -- Hood -- Binder -- New York, N.Y. -- Science. 1998 Sep 4;281(5382):1480-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉R. P. Lin, Space Sciences Laboratory and Physics Department, University of California, Berkeley, CA 94720, USA. D. L. Mitchell, D. W. Curtis, K. A. Anderson, C. W. Carlson, J. McFadden, Space Sciences Laboratory, University of California〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9727969" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-20
    Description: Stimulation of T lymphocytes results in a rapid increase in intracellular calcium concentration ([Ca2+]i) that parallels the activation of Ca2+-calmodulin-dependent protein kinase IV (CaMKIV), a nuclear enzyme that can phosphorylate and activate the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB). However, inactivation of CaMKIV occurs despite the sustained increase in [Ca2+]i that is required for T cell activation. A stable and stoichiometric complex of CaMKIV with protein serine-threonine phosphatase 2A (PP2A) was identified in which PP2A dephosphorylates CaMKIV and functions as a negative regulator of CaMKIV signaling. In Jurkat T cells, inhibition of PP2A activity by small t antigen enhanced activation of CREB-mediated transcription by CaMKIV. These findings reveal an intracellular signaling mechanism whereby a protein serine-threonine kinase (CaMKIV) is regulated by a tightly associated protein serine-threonine phosphatase (PP2A).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westphal, R S -- Anderson, K A -- Means, A R -- Wadzinski, B E -- GM33976/GM/NIGMS NIH HHS/ -- GM51366/GM/NIGMS NIH HHS/ -- HD07503/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1998 May 22;280(5367):1258-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9596578" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Polyomavirus Transforming/metabolism ; Brain/enzymology ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 4 ; Calcium-Calmodulin-Dependent Protein Kinases/genetics/isolation & ; purification/*metabolism ; Calmodulin/metabolism ; Coenzymes/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Enzyme Activation ; Humans ; Jurkat Cells ; Lymphocyte Activation ; Mutation ; Phosphoprotein Phosphatases/isolation & purification/*metabolism ; Phosphorylation ; Protein Phosphatase 2 ; Rats ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; T-Lymphocytes/*enzymology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The hot plasma environment at jupiter: ulysses results (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-09-11
    Description: Measurements of the hot plasma environment during the Ulysses flyby of Jupiter have revealed several new discoveries related to this large rotating astrophysical system. The Jovian magnetosphere was found by Ulysses to be very extended, with the day-side magnetopause located at approximately 105 Jupiter radii. The heavy ion (sulfur, oxygen, and sodium) population in the day-side magnetosphere increased sharply at approximately 86 Jupiter radii. This is somewhat more extended than the "inner" magnetosphere boundary region identified by the Voyager hot plasma measurements. In the day-side magnetosphere, the ion fluxes have the anisotropy direction expected for corotation with the planet, with the magnitude of the anisotropy increasing when the spacecraft becomes more immersed in the hot plasma sheet. The relative abundances of sulfur, oxygen, and sodium to helium decreased somewhat with decreasing radial distance from the planet on the day-side, which suggests that the abundances of the Jupiter-derived species are dependent on latitude. In the dusk-side, high-latitude region, intense fluxes of counter-streaming ions and electrons were discovered from the edge of the plasma sheet to the dusk-side magnetopause. These beams of electrons and ions were found to be very tightly aligned with the magnetic field and to be superimposed on a time- and space-variable isotropic hot plasma background. The currents carried by the measured hot plasma particles are typically approximately 1.6 x 10(-4) microamperes per square meter or approximately 8 x 10(5) amperes per squared Jupiter radius throughout the high-latitude magnetosphere volume. It is likely that the intense particle beams discovered at high Jovian latitudes produce auroras in the polar caps of the planet.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lanzerotti, L J -- Armstrong, T P -- Gold, R E -- Anderson, K A -- Krimigis, S M -- Lin, R P -- Pick, M -- Roelof, E C -- Sarris, E T -- Simnett, G M -- Maclennan, C G -- Choo, H T -- Tappin, S J -- New York, N.Y. -- Science. 1992 Sep 11;257(5076):1518-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17776161" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Over the southern solar pole: low-energy interplanetary charged particles (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-05-19
    Description: The heliosphere instrument for spectrum, composition, and anisotropy (HISCALE) recorded the fluxes of low-energy ions and electrons (〉 50 kiloelectron volts) when Ulysses crossed the southern solar polar region and revealed that the large-scale structure of the heliosphere to at least approximately -75 degrees was significantly influenced by the near-equatorial heliospheric current sheet. Electrons in particular were accelerated by the current sheet-produced and poleward-propagating interplanetary reverse shock at helioradii far from the Ulysses location. At heliolatitudes higher than approximately -75 degrees on the Ulysses ascent to the pole and approximately -50 degrees on the descent, small, less regular enhancements of the lowest energy electron fluxes were measured whose relations to the current sheet were less clear. The anomalous component of low-energy (approximately 2 to 5 megaelectron volts per nucleon) oxygen flux at the highest heliolatitudes was found to be approximately 10(-8) [per square centimeter per second per steradian (per kiloelectronvolt per nucleon)]; the anomalous Ne/O ratio was approximately 0.25.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lanzerotti, L J -- Armstrong, T P -- Gold, R E -- Maclennan, C G -- Roelof, E C -- Simnett, G M -- Thomson, D J -- Anderson, K A -- Hawkins, S E 3rd -- Krimigis, S M -- New York, N.Y. -- Science. 1995 May 19;268(5213):1010-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉AT&T Bell Laboratories, Murray Hill, NJ 07974, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7754378" target="_blank"〉PubMed〈/a〉
    Keywords: Electrons ; *Extraterrestrial Environment ; Ions ; Oxygen ; *Solar System ; Spacecraft
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Evidence for chain molecules enriched in carbon, hydrogen, and oxygen in comet halley (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-08-07
    Description: In situ measurements of the composition and spatial distribution of heavy thermal positive ions in the coma of comet Halley were made with the heavy-ion analyzer RPA2-PICCA aboard the Giotto spacecraft. Above 50 atomic mass units an ordered series of mass peaks centered at 61, 75, 91, and 105 atomic mass units were observed. Each peak appears to be composed of three or more closely spaced masses. The abundances decrease and the dissociation rates increase smoothly with increasing mass. These observations suggest the presence of chain molecules that are enriched in carbon, oxygen, and hydrogen, such as polyoxymethylene (polymerized formaldehyde), in comet Halley.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitchell, D L -- Lin, R P -- Anderson, K A -- Carlson, C W -- Curtis, D W -- Korth, A -- Reme, H -- Sauvaud, J A -- D'Uston, C -- Mendis, D A -- New York, N.Y. -- Science. 1987 Aug 7;237(4815):626-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17758562" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Electronic Resource
    Electronic Resource
    Energetic Particles in the Earth's Magnetic Field (1966)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nuclear and Particle Science 16 (1966), S. 291-344 
    Details
    ISSN: 0066-4243
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ns.16.120166.001451
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