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  • 1
    Electronic Resource
    Electronic Resource
    Sustained release of salmon calcitonin in vivo from lactide: Glycolide copolymer depots (1993)
    Springer
    Calcified tissue international 52 (1993), S. 361-364 
    Details
    ISSN: 1432-0827
    Keywords: Calcitonin ; Sustained release ; Copolymer depot ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Studies were carried out to determine whether monolithic depot formulations, prepared using lactide:glycolide copolymers, could be used to administer salmon calcitonin (sCT) to rats in vivo. Formulations containing 2, 5, or 10% (w/w) sCT were administered subcutaneously to female Wistar strain rats. Release of sCT was determined by measurement of peptide in plasma using a specific radioimmunoassay and by measurement of residual sCT in the depots after recovery at postmortem. Plasma calcium concentrations and cumulative weight gain of the animals were used to measure pharmacological effects of the released sCT. Release of sCT from the depots was controlled by the copolymer and was sustained for periods up to 10 days. However, the release of sCT from the depots did not significantly alter plasma calcium concentrations, and effects on cumulative weight gain were small and transient. Peptide loading of the formulations was shown to modify sCT release. Maximal release of sCT from depots containing 10% peptide occurred over a 7 to 14-day period postadministration, with 5% sCT release occurred between days 11 and 14, and with 2% sCT, the period of maximal release was between days 11 and 18. Release of peptide from the depots was essentially complete by 21 days postadministration irrespective of the peptide loading. These data suggest that lactide:glycolide copolymer depots may have application for the convenient clinical administration of sCT in metabolic bone diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310200
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  • 2
    Electronic Resource
    Electronic Resource
    The Properties of n-ZnO/p-SiC Heterojunctions and their Potential Applications for Devices (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 527-529 (Oct. 2006), p. 1571-1574 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Heteroepitaxial n-ZnO films have been grown on commercial p-type 6H-SiC substratesby plasma-assisted molecular-beam epitaxy, and n-ZnO/p-SiC heterojunction mesa structures havebeen fabricated and their photoresponse properties have been studied. Current-voltagecharacteristics of the structures had a very good rectifying diode-like behavior with a leakagecurrent less than 2 x 10-4 A/cm2 at -10 V, a breakdown voltage greater than 20 V, a forward turn onvoltage of ∼5 V, and a forward current of ∼2 A/cm2 at 8 V. Photosensitivity of the diodes, whenilluminated from ZnO side, was studied at room temperature and photoresponsivity of as high as0.045 A/W at -7.5 V reverse bias was observed for photon energies higher than 3.0 eV
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/14/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.527-529.1571.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    High Power Photoconductive Switch of 4H-SiC with Damage-Free Electrodes by Using n〈sup〉+〈/sup〉-GaN Subcontact Layer (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 527-529 (Oct. 2006), p. 1387-1390 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: 4H SiC high power photoconductive semiconductor switching devices were fabricated. Ahighly doped n+-GaN subcontact epilayer was grown on SiC by organometallic vapor phase epitaxyin order to improve ohmic contact and avoid contact damage or degradation due to currentfilamentation, under high power operation. With an n+-GaN subcontact layer, the contact resistancewas reduced and current crowding alleviated. Therefore the electrodes were not damaged ordegraded at high power operation. Photocurrent up to 200 A and breakdown voltage up to 2900 Vhave been observed for the devices
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/14/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.527-529.1387.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Aerobic Fermentation of Whey by a Nitrogen-fixing Strain of Aerobacter aerogenes (1959)
    [s.l.] : Nature Publishing Group
    Nature 183 (1959), S. 992-993 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] All fermentations reported here were carried out in New Brunswick Model F07 fermentors of 7-5-1. capacity. 5 1. of acid whey were neutralized with potassium hydroxide, added to a fermentor, and sterilized by aut ocla ving at 15 Ib. pressure for 15 min. The fermentors were inoculated with young ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/183992a0
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  • 5
    Electronic Resource
    Electronic Resource
    Estimation of Protein in Cellular Material (1961)
    [s.l.] : Nature Publishing Group
    Nature 191 (1961), S. 492-493 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The method reported here is based on the fact that most solid protein samples, including precipitates made with trichloroacetic acid or by heat coagulation, are soluble in a dilute base. By using half-strength biuret reagent (containing 0-4M sodium hydroxide) it is possible to extract and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/191492a0
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of lattice mismatch and thermal annealing on deep traps and interface states in Ga0.92In0.08As(n+)/GaAs(p) heterojunctions (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 4362-4366 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of the lattice-mismatch-induced defects on deep level traps in Ga0.92In0.08As(n+)/GaAs(p) heterojunction diodes have been studied by means of various deep level transient spectroscopy techniques and the frequency-dependent capacitance-voltage (C-V-f) characteristics. Three hole traps at 0.58, 0.42, and 0.27 eV were observed. We attribute the 0.42 eV trap to Cu impurity, the 0.58 eV trap to VGa or Fe, and the 0.27 eV trap to a complex associated with the 0.42 and 0.58 eV traps. Depth profiles of these hole traps in the GaAs side were measured in different lattice-mismatched samples. The depth profile data near the interface and from deep inside the bulk show evidence of impurity gettering by the mismatched interface. We also found that the concentrations of these traps were reduced by rapid thermal annealing. A U-shaped energy distribution of the interface states was obtained from the C-V-f measurements. For an in-plane mismatch greater than 0.25%, the interface state density shows no obvious dependence on the in-plane lattice mismatch, while at smaller mismatch the interface state density increases with increasing mismatch. The interface state density was on the order of 1011 cm−2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.352821
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  • 7
    Electronic Resource
    Electronic Resource
    A Statistical Paradox in Auditing (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Abacus 30 (1994), S. 0 
    Details
    ISSN: 1467-6281
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The decision rule in a standard form of hypothesis testing in auditing is to reject the null hypothesis (and thus the auditee's account balance) if the 100(1-β)% confidence interval estimate of the population average error lies even partly outside the null (immaterial) interval. The effect of this rule is to fix the minimum power of the test (i.e., the minimum probability of rejecting a materially incorrect balance) at 1-β/2 (assuming a two-sided test). An unseen theoretical deficiency of the stated decision rule is that, from a Bayesian (evidential) rather than long-run error-frequency standpoint, marginal rejection of the null hypothesis supports that hypothesis. Indeed if the sample size is large enough, an account balance which is marginally rejected by the auditor, using a conventional test, has an‘objective’ (independent-of-prior) posterior probability arbitrarily close to one. In these circumstances, any call by the auditor for adjustment of the stated account balance, or additional sampling, would be seen as‘over-servicing’ and rightfully resisted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6281.1994.tb00341.x
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  • 8
    Electronic Resource
    Electronic Resource
    Sample Size and the Strength of Evidence: A Bayesian Interpretation of Binomial Tests of the Information Content of Qualified Audit Reports (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Abacus 26 (1990), S. 0 
    Details
    ISSN: 1467-6281
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Lindley (1957) demonstrated that, from a Bayesian standpoint, a given level of statistical significance P carries less evidence against the null hypothesis Ho the larger (more powerful) the test. Moreover, if the sample is sufficiently large, a result significant on Ho at 5% or lower may represent strong evidence in support of Ho, not against it. Contrary to Lindley's argument, a great many applied researchers, trained exclusively in orthodox statistics, feel intuitively that to‘reject’ the null hypothesis Ho at (say) α= 5% is more convincing evidence, ceteris paribus, against Ho the larger the sample. This is a consistent finding of surveys in empirical psychology. Similarly, in accounting, see the principles for interpreting statistical tests suggested by Burgstahler (1987). In econometrics, ‘Lindley's paradox’ (as it has become known in statistics) has been explained in well known books by Zellner (1971), Leamer (1978) and Judge, Hill, Griffiths, Lutkepohl and Lee (1982), but is not widely appreciated. The objective of this paper is to reiterate the Bayesian argument in an applied context familiar to empirical researchers in accounting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6281.1990.tb00230.x
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  • 9
    Electronic Resource
    Electronic Resource
    Replacement Cost Asset Valuation and Regulation of Energy Infrastructure Tariffs (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Abacus 39 (2003), S. 0 
    Details
    ISSN: 1467-6281
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: In Australia, access tariffs (rental charges) paid by third party users to the owners of energy transmission assets (e.g., gas pipelines) are determined by regulators on the basis of their depreciated optimized replacement cost (known as DORC). Reliance on the replacement cost, rather than actual cost, of existing assets inflates tariffs and incites the criticism that asset owners earn a return on investments of a scale never made. The economic rationale of the regulators’ model is that it emulates the workings of a contestable market, by setting tariffs at a level just short of that required to motivate a new entrant (system duplication). Properly reconstructed, this model constitutes a dynamic and internally consistent theory of replacement cost valuation and depreciation. Its mathematical consequences, however, especially with regard to the valuation of sunk assets with long times to expiry, are shown to be practically and politically unpalatable. In particular, the implied tariff levels for such assets are very close to those that would apply to new infrastructure assets built today at today's prices. Regulators unwilling to accept this implication of a new-entrant-exclusion pricing logic are left with no alternative framework for DORC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-6281.00118
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  • 10
    Electronic Resource
    Electronic Resource
    A NEW TECHNIQUE FOR THE ACCURATE AERIAL APPLICATION OF HERBICIDES TO DRAINAGE CHANNELS WITH NEGLIGIBLE SPRAY DRIFT (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Weed research 6 (1966), S. 0 
    Details
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary. Difficulties of access met with in Britain when applying dalapon to emergent water weeds in drainage channels led to work starting in 1964 on the development of a method of accurate aerial application of aqueous solutions of herbicide. The narrow, sinuous nature of the targets and the proximity of susceptible crops made it necessary to minimize spray drift and maintain a constant height and a slow speed. Nozzles designed to give large droplets were tested for droplet size and distribution. Selected nozzles were then tested from a helicopter in the field and the effect of their spray characteristics on the biological performance of dalapon was assessed. No daman occurred as a result of spray drift and satisfactory control of Phragmites communis, Typha angustifolia and T. latifolia was achieved with a lower dose of dalapon in a lower volume of spray than previously considered necessary for ground applications.Une nouvelle technique pour l'application précise d'herbicides par voie aérienne sur les canaux de drainage, avec des risques négligeables d'entrainement
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3180.1966.tb00890.x
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