Publication Date:
2015-03-08
Description:
Article Mutations in the CCM3 gene in humans lead to severe forms of cerebral cavernous malformation. Here, Lant et al. shed light on the mechanism of CCM-3 function in C. elegans , and show that CCM-3 ablation leads to defects in excretory canal extension and the formation of cysts reminiscent of human malformations. Nature Communications doi: 10.1038/ncomms7449 Authors: Benjamin Lant, Bin Yu, Marilyn Goudreault, Doug Holmyard, James D.R. Knight, Peter Xu, Linda Zhao, Kelly Chin, Evan Wallace, Mei Zhen, Anne-Claude Gingras, W Brent Derry
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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