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  • 1
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    Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-12
    Description: Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses. In hippocampal CA1 pyramidal neurons, GluR-A-/- mice showed a reduction in functional AMPA receptors, with the remaining receptors preferentially targeted to synapses. Thus, the CA1 soma-patch currents were strongly reduced, but glutamatergic synaptic currents were unaltered; and evoked dendritic and spinous Ca2+ transients, Ca2+-dependent gene activation, and hippocampal field potentials were as in the wild type. In adult GluR-A-/- mice, associative long-term potentiation (LTP) was absent in CA3 to CA1 synapses, but spatial learning in the water maze was not impaired. The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zamanillo, D -- Sprengel, R -- Hvalby, O -- Jensen, V -- Burnashev, N -- Rozov, A -- Kaiser, K M -- Koster, H J -- Borchardt, T -- Worley, P -- Lubke, J -- Frotscher, M -- Kelly, P H -- Sommer, B -- Andersen, P -- Seeburg, P H -- Sakmann, B -- New York, N.Y. -- Science. 1999 Jun 11;284(5421):1805-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Neuroscience, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10364547" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Bicuculline/pharmacology ; Calcium/metabolism ; Dendrites/physiology/ultrastructure ; GABA Antagonists/pharmacology ; Gene Expression ; Gene Targeting ; Genes, Immediate-Early ; Glutamic Acid/pharmacology/physiology ; Hippocampus/cytology/physiology ; Long-Term Potentiation/*physiology ; *Maze Learning ; Mice ; Mice, Inbred C57BL ; Pyramidal Cells/*physiology/ultrastructure ; Receptors, AMPA/genetics/*physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Synapses/*physiology/ultrastructure ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-10
    Description: Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Markram, H -- Lubke, J -- Frotscher, M -- Sakmann, B -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):213-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D-69120 Heidelberg, Germany. bnmark@weizmann.weizmann.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8985014" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Calcium/metabolism ; Cerebral Cortex/cytology/physiology ; Dendrites/*physiology ; Down-Regulation ; Electric Stimulation ; In Vitro Techniques ; Patch-Clamp Techniques ; Pyramidal Cells/*physiology ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/*physiology ; *Synaptic Transmission ; Time Factors ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    High-probability uniquantal transmission at excitatory synapses in barrel cortex (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-12-13
    Description: The number of vesicles released at excitatory synapses and the number of release sites per synaptic connection are key determinants of information processing in the cortex, yet they remain uncertain. Here we show that the number of functional release sites and the number of anatomically identified synaptic contacts are equal at connections between spiny stellate and pyramidal cells in rat barrel cortex. Moreover, our results indicate that the amount of transmitter released per synaptic contact is independent of release probability and the intrinsic release probability is high. These properties suggest that connections between layer 4 and layer 2/3 are tuned for reliable transmission of spatially distributed, timing-based signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silver, R Angus -- Lubke, Joachim -- Sakmann, Bert -- Feldmeyer, Dirk -- New York, N.Y. -- Science. 2003 Dec 12;302(5652):1981-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University College London, Gower Street, London WC1E 6BT, U.K. a.silver@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14671309" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Analysis of Variance ; Animals ; Axons/physiology/ultrastructure ; Calcium/pharmacology ; Dendrites/physiology/ultrastructure ; Dipeptides/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Glutamic Acid/metabolism ; Image Processing, Computer-Assisted ; In Vitro Techniques ; Kynurenic Acid/pharmacology ; Lysine/*analogs & derivatives ; Patch-Clamp Techniques ; Probability ; Pyramidal Cells/physiology ; Rats ; Rats, Wistar ; Receptors, Glutamate/metabolism ; Somatosensory Cortex/cytology/*physiology ; Synapses/*physiology ; Synaptic Transmission/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    FM1-43 dye ultrastructural localization in and release from frog motor nerve terminals. (1996)
    National Academy of Sciences
    Details
    Publication Date: 1996-03-05
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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