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  • 1
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    Die seismischen Geschwindigkeiten der jüngeren Molasse im Ostschweizerischen und Deutschen Alpenvorland (1969)
    In:  Geophys. Prosp., Kunming, China, 4, vol. 17, no. 1, pp. 111-125, pp. 2353, (ISSN: 1340-4202)
    Details
    Publication Date: 1969
    Keywords: Seismology ; Velocity analysis ; Travel time
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression (2015)
    Oxford University Press
    Details
    Publication Date: 2015-08-27
    Description: Preferential dysfunction/degeneration of midbrain substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons contributes to the main movement symptoms manifested in Parkinson's disease (PD). Although the Leucine-rich repeat kinase 2 ( LRRK2 ) G2019S missense mutation ( LRRK2 G2019S) is the most common causative genetic factor linked to PD, the effects of LRRK2 G2019S on the function and survival of SNpc DA neurons are poorly understood. Using a binary gene expression system, we generated transgenic mice expressing either wild-type human LRRK2 (WT mice) or the LRRK2 G2019S mutation (G2019S mice) selectively in the midbrain DA neurons. Here we show that overexpression of LRRK2 G2019S did not induce overt motor abnormalities or substantial SNpc DA neuron loss. However, the LRRK2 G2019S mutation impaired dopamine homeostasis and release in aged mice. This reduction in dopamine content/release coincided with the degeneration of DA axon terminals and decreased expression of DA neuron-enriched genes tyrosine hydroxylase (TH), vesicular monoamine transporter 2, dopamine transporter and aldehyde dehydrogenase 1. These factors are responsible for dopamine synthesis, transport and degradation, and their expression is regulated by transcription factor paired-like homeodomain 3 (PITX3). Levels of Pitx3 mRNA and protein were similarly decreased in the SNpc DA neurons of aged G2019S mice. Together, these findings suggest that PITX3-dependent transcription regulation could be one of the many potential mechanisms by which LRRK2 G2019S acts in SNpc DA neurons, resulting in downregulation of its downstream target genes critical for dopamine homeostasis and release.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 3
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    Role of density gradient driven trapped electron mode turbulence in the H-mode inner core with electron heating (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-05-11
    Description: A series of DIII-D [J. L. Luxon, Nucl. Fusion 42 , 614 (2002)] low torque quiescent H-mode experiments show that density gradient driven trapped electron mode (DGTEM) turbulence dominates the inner core of H-mode plasmas during strong electron cyclotron heating (ECH). Adding 3.4 MW ECH doubles T e / T i from 0.5 to 1.0, which halves the linear DGTEM critical density gradient, locally reducing density peaking, while transport in all channels displays extreme stiffness in the density gradient. This suggests that fusion α -heating may degrade inner core confinement in H-mode plasmas with moderate density peaking and low collisionality, with equal electron and ion temperatures, key conditions expected in burning plasmas. Gyrokinetic simulations using GYRO [J. Candy and R. E. Waltz, J. Comput. Phys. 186 , 545 (2003)] (and GENE [Jenko et al. , Phys. Plasmas 7 , 1904 (2000)]) closely match not only particle, energy, and momentum fluxes but also density fluctuation spectra from Doppler backscattering (DBS), with and without ECH. Inner core DBS density fluctuations display discrete frequencies with adjacent toroidal mode numbers, which we identify as DGTEMs. GS2 [Dorland et al ., Phys. Rev. Lett. 85 , 5579 (2000)] predictions show the DGTEM can be suppressed, to avoid degradation with electron heating, by broadening the current density profile to attain q 0 〉 q min 〉 1 .
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 4
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    Avoiding Tokamak Disruptions by Applying Static Magnetic Fields That Align Locked Modes with Stabilizing Wave-Driven Currents (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-10-21
    Description: Author(s): F. A. Volpe, A. Hyatt, R. J. La Haye, M. J. Lanctot, J. Lohr, R. Prater, E. J. Strait, and A. Welander Nonrotating (“locked”) magnetic islands often lead to complete losses of confinement in tokamak plasmas, called major disruptions. Here locked islands were suppressed for the first time, by a combination of applied three-dimensional magnetic fields and injected millimeter waves. The applied fields w… [Phys. Rev. Lett. 115, 175002] Published Mon Oct 19, 2015
    Keywords: Plasma and Beam Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Improved cross-calibration of Thomson scattering and electron cyclotron emission with ECH on DIII-D (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-08-09
    Description: Thomson scattering produces n e profiles from measurement of scattered laser beam intensity. Rayleigh scattering provides a first calibration of the relation n e ∝ I TS , which depends on many factors (e.g., laser alignment and power, optics, and measurement systems). On DIII-D, the n e calibration is adjusted against an absolute n e from the density-driven cutoff of the 48 channel 2nd harmonic X-mode electron cyclotron emission system. This method has been used to calibrate Thomson n e from the edge to near the core ( r / a 〉 0.15). Application of core electron cyclotron heating improves the quality of cutoff and depth of its penetration into the core, and also changes underlying MHD activity, minimizing crashes which confound calibration. Less fueling is needed as “ECH pump-out” generates a plasma ready to take up gas. On removal of gyrotron power, cutoff penetrates into the core as channels fall successively and smoothly into cutoff.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 6
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    Mutational heterogeneity in cancer and the search for new cancer-associated genes (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-06-19
    Description: Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour-normal samples followed by mathematical analysis to identify those genes in which mutations occur more frequently than expected by random chance. Here we describe a fundamental problem with cancer genome studies: as the sample size increases, the list of putatively significant genes produced by current analytical methods burgeons into the hundreds. The list includes many implausible genes (such as those encoding olfactory receptors and the muscle protein titin), suggesting extensive false-positive findings that overshadow true driver events. We show that this problem stems largely from mutational heterogeneity and provide a novel analytical methodology, MutSigCV, for resolving the problem. We apply MutSigCV to exome sequences from 3,083 tumour-normal pairs and discover extraordinary variation in mutation frequency and spectrum within cancer types, which sheds light on mutational processes and disease aetiology, and in mutation frequency across the genome, which is strongly correlated with DNA replication timing and also with transcriptional activity. By incorporating mutational heterogeneity into the analyses, MutSigCV is able to eliminate most of the apparent artefactual findings and enable the identification of genes truly associated with cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919509/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919509/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawrence, Michael S -- Stojanov, Petar -- Polak, Paz -- Kryukov, Gregory V -- Cibulskis, Kristian -- Sivachenko, Andrey -- Carter, Scott L -- Stewart, Chip -- Mermel, Craig H -- Roberts, Steven A -- Kiezun, Adam -- Hammerman, Peter S -- McKenna, Aaron -- Drier, Yotam -- Zou, Lihua -- Ramos, Alex H -- Pugh, Trevor J -- Stransky, Nicolas -- Helman, Elena -- Kim, Jaegil -- Sougnez, Carrie -- Ambrogio, Lauren -- Nickerson, Elizabeth -- Shefler, Erica -- Cortes, Maria L -- Auclair, Daniel -- Saksena, Gordon -- Voet, Douglas -- Noble, Michael -- DiCara, Daniel -- Lin, Pei -- Lichtenstein, Lee -- Heiman, David I -- Fennell, Timothy -- Imielinski, Marcin -- Hernandez, Bryan -- Hodis, Eran -- Baca, Sylvan -- Dulak, Austin M -- Lohr, Jens -- Landau, Dan-Avi -- Wu, Catherine J -- Melendez-Zajgla, Jorge -- Hidalgo-Miranda, Alfredo -- Koren, Amnon -- McCarroll, Steven A -- Mora, Jaume -- Lee, Ryan S -- Crompton, Brian -- Onofrio, Robert -- Parkin, Melissa -- Winckler, Wendy -- Ardlie, Kristin -- Gabriel, Stacey B -- Roberts, Charles W M -- Biegel, Jaclyn A -- Stegmaier, Kimberly -- Bass, Adam J -- Garraway, Levi A -- Meyerson, Matthew -- Golub, Todd R -- Gordenin, Dmitry A -- Sunyaev, Shamil -- Lander, Eric S -- Getz, Gad -- ES065073/ES/NIEHS NIH HHS/ -- T32 CA009172/CA/NCI NIH HHS/ -- T32 CA009216/CA/NCI NIH HHS/ -- T32 GM007753/GM/NIGMS NIH HHS/ -- U24 CA143845/CA/NCI NIH HHS/ -- U54 HG003067/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- Intramural NIH HHS/ -- England -- Nature. 2013 Jul 11;499(7457):214-8. doi: 10.1038/nature12213. Epub 2013 Jun 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23770567" target="_blank"〉PubMed〈/a〉
    Keywords: Artifacts ; DNA Replication Timing ; Exome/genetics ; False Positive Reactions ; Gene Expression ; *Genetic Heterogeneity ; Genome, Human/genetics ; Humans ; Lung Neoplasms/genetics ; Mutation/*genetics ; Mutation Rate ; Neoplasms/classification/*genetics/pathology ; Neoplasms, Squamous Cell/genetics ; Oncogenes/*genetics ; Reproducibility of Results ; Sample Size
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Multiferroic properties of $R\mathrm{F}{\mathrm{e}}_{0.5}\mathrm{C}{\mathrm{o}}_{0.5}{\mathrm{O}}_{3}$ with $R=\mathrm{Tm}$, Er, Ho, Dy, and Tb (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-10-04
    Description: Author(s): J. Lohr, F. Pomiro, V. Pomjakushin, J. A. Alonso, R. E. Carbonio, and R. D. Sánchez We present a detailed study of the thermal dependence of the neutron powder diffraction (NPD) of R F e 0.5 C o 0.5 O 3 perovskites ( R = Tm , Er, Ho, Dy, and Tb) combined with a complete characterization of their magnetic, electric transport and ferroelectric properties. All samples are described with an orthor... [Phys. Rev. B 98, 134405] Published Wed Oct 03, 2018
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Feldspar dissolution-enhanced porosity in Paleoproterozoic shale reservoir facies from the Barney Creek Formation (McArthur Basin, Australia) (2015)
    American Association of Petroleum Geologists (AAPG)
    Details
    Publication Date: 2015-09-08
    Description: The Paleoproterozoic Barney Creek Formation (BCF; McArthur Basin, Australia) is one of the oldest active hydrocarbon systems on Earth with oil and gas shows present within organic-rich intervals (up to 7 wt. % total organic carbon). We combine bulk geochemical analyses, pore-space characterization, and high-resolution electron imaging techniques to characterize the evolution of the BCF pore system with maturity. A thermal gradient from the pre-oil window (0.48% calc. $${R}_{\mathrm{o}}$$ ) to gas window (1.01% calc. $${R}_{\mathrm{o}}$$ ) shows a progressive change in pore networks with the loss of organic-hosted pores dominant in thermally immature samples to porosity increasingly associated with the mineral matrix with thermal maturity. Precipitation of fine-grained, high surface area cements reduced porosity within the oil window, whereas feldspar and dolomite dissolution and creation of secondary pores increased porosity within the gas window. The abundance of feldspar grains (up to 50%) provided a significant potential for secondary pore formation as well as a source of silica and clay cement. This study identifies a first-order linkage between the chemically reactive sediments that are key to the reservoir properties in the BCF and a provenance and/or weathering intensity conducive to supplying fine-grained, mineralogically immature sediments during deposition. These findings likely apply more broadly to other chemically immature mudrocks typical of Precambrian age sediments or Phanerozoic settings subject to limited chemical weathering.
    Print ISSN: 0149-1423
    Electronic ISSN: 0149-1423
    Topics: Geosciences
    Published by American Association of Petroleum Geologists (AAPG)
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  • 9
    Electronic Resource
    Electronic Resource
    Quantification, immunoaffinity purification and sequence analysis of a pigment-dispersing hormone of the shore crab, Carcinus maenas (L.)
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 104 (1993), S. 699-706 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(93)90200-O
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Millimeter wave polarimeter for characterizing high-power plasma heating systems (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 1994-1998 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We have built a millimeter wave polarimeter which measures wave polarization parameters: the polarization angle, and the ellipticity including field spin direction in an evacuated high-power system. The polarimeter was applied to diagnose the 1 MW level electron-cyclotron plasma heating system at 110 GHz for the DIII-D tokamak. We have observed the time-dependent behavior of the gyrotrons and have characterized and calibrated the high-power transmission system which consists of grooved mirror polarizers, miter bends, switches, and corrugated wave guides. This article describes the principle of operation and the design method of the polarimeter and the examples of measurements. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149701
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