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  • 1
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    T-cell receptor is not hardwired to engage MHC [Immunology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-11-08
    Description: The bias of αβ T cells for MHC ligands has been proposed to be intrinsic to the T-cell receptor (TCR). Equally, the CD4 and CD8 coreceptors contribute to ligand restriction by colocalizing Lck with the TCR when MHC ligands are engaged. To determine the importance of intrinsic ligand bias, the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Minimal 3-3-1 model with only two Higgs triplets (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-11-15
    Description: Author(s): J. G. Ferreira, Jr., P. R. D. Pinheiro, C. A. de S. Pires, and P. S. Rodrigues da Silva [Phys. Rev. D 84, 095019] Published Mon Nov 14, 2011
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    A gut lipid messenger links excess dietary fat to dopamine deficiency (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-21
    Description: Excessive intake of dietary fats leads to diminished brain dopaminergic function. It has been proposed that dopamine deficiency exacerbates obesity by provoking compensatory overfeeding as one way to restore reward sensitivity. However, the physiological mechanisms linking prolonged high-fat intake to dopamine deficiency remain elusive. We show that administering oleoylethanolamine, a gastrointestinal lipid messenger whose synthesis is suppressed after prolonged high-fat exposure, is sufficient to restore gut-stimulated dopamine release in high-fat-fed mice. Administering oleoylethanolamine to high-fat-fed mice also eliminated motivation deficits during flavorless intragastric feeding and increased oral intake of low-fat emulsions. Our findings suggest that high-fat-induced gastrointestinal dysfunctions play a key role in dopamine deficiency and that restoring gut-generated lipid signaling may increase the reward value of less palatable, yet healthier, foods.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tellez, Luis A -- Medina, Sara -- Han, Wenfei -- Ferreira, Jozelia G -- Licona-Limon, Paula -- Ren, Xueying -- Lam, Tukiet T -- Schwartz, Gary J -- de Araujo, Ivan E -- DC009997/DC/NIDCD NIH HHS/ -- DK020541/DK/NIDDK NIH HHS/ -- DK026687/DK/NIDDK NIH HHS/ -- DK085579/DK/NIDDK NIH HHS/ -- P30 DK026687/DK/NIDDK NIH HHS/ -- UL1RR024139/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 16;341(6147):800-2. doi: 10.1126/science.1239275.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The John B. Pierce Laboratory, New Haven, CT 06519, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite ; Corpus Striatum/*metabolism ; Dietary Fats/*administration & dosage ; Dopamine/deficiency/*metabolism ; Endocannabinoids/*administration & dosage/biosynthesis/*physiology ; Energy Intake ; Ethanolamines/*administration & dosage ; Feeding Behavior ; Gastrointestinal Tract/*metabolism ; Homeostasis ; Intestine, Small/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oleic Acids/*administration & dosage/biosynthesis/*physiology ; PPAR alpha/genetics/metabolism ; Reward ; Signal Transduction ; Vagus Nerve/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Higgs sector of the supersymmetric reduced 331 model (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-11-12
    Description: Author(s): J. G. Ferreira, Jr., C. A. de S. Pires, P. S. Rodrigues da Silva, and A. Sampieri A supersymmetric version of the recently proposed reduced minimal 331 model is considered and its Higgs sector is investigated. We focus on the mass spectrum of the lightest scalars of the model. We show that the Higgs mass of 125 GeV requires substantial radiative corrections. However, stops may de... [Phys. Rev. D 88, 105013] Published Mon Nov 11, 2013
    Keywords: Field theory, formal particle theory
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Inflation scenario driven by a low energy physics inflaton (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-11-09
    Description: Author(s): J. G. Ferreira, Jr., C. A. de S. Pires, J. G. Rodrigues, and P. S. Rodrigues da Silva It is a longstanding desire of cosmologists, and particle physicists as well, to connect inflation to low energy physics, culminating, for instance, in what is known as Higgs inflation. The condition for the standard Higgs boson playing the role of the inflaton, and driving sucessfully inflation, is... [Phys. Rev. D 96, 103504] Published Wed Nov 08, 2017
    Keywords: Cosmology
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
    Electronic Resource
    Electronic Resource
    AFLP genetic maps of Eucalyptus globulus and E. tereticornis (1998)
    Springer
    Theoretical and applied genetics 96 (1998), S. 727-737 
    Details
    ISSN: 1432-2242
    Keywords: Key words Genetic map ; Linkage ; Eucalyptus ; AFLP marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Amplified fragment length polymorphism (AFLP) analysis is a rapid and efficient technique for detecting large numbers of DNA markers in eucalypts. We have used AFLP markers in a two-way pseudo-testcross strategy to generate genetic maps of two clones of different Eucalyptus species (E. tereticornis and E. globulus). Of 606 polymorphic fragments scored, 487 segregated in a 1 : 1 ratio, corresponding to DNA polymorphisms heterozygous in one parent and null in the other. In the maternal E. tereticornis map, 268 markers were ordered in 14 linkage groups (919 cM); the paternal E. globulus map had 200 markers in 16 linkage groups (967 cM). Results from PGRI software were compared with MAPMAKER. The average density of markers was approximately 1 per 3.9 cM. Framework markers were ordered with an average confidence level of 90%, covering 80–100% of the estimated Eucalyptus genome size. In order to investigate the homologies between the E. tereticornis and the E. globulus genetic linkage maps, we included 19 markers segregating 3 : 1 in the analysis. Some homeologous linkage groups were recognized. The linkage data developed in these maps will be used to detect loci controlling commercially important traits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050795
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  • 7
    Electronic Resource
    Electronic Resource
    Genetic dissection of vegetative propagation traits in Eucalyptus tereticornis and E. globulus (1999)
    Springer
    Theoretical and applied genetics 99 (1999), S. 936-946 
    Details
    ISSN: 1432-2242
    Keywords: Key words AFLP ; Pseudo-testcross ; Eucalyptus ; QTL ; Vegetative propagation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  We have detected quantitative trait loci (QTLs) affecting vegetative propagation traits in Eucalyptus tereticornis and Eucalyptus globulus. Using amplified fragment length polymorphism (AFLP) genetic linkage maps, the inheritance of 199 markers was assessed in 94 F1 individuals with extreme adventitious rooting response, and in 221 randomly chosen F1 individuals. Phenotypes were scored in 1995 and 1996. QTL analyses were performed using chi-square tests (χ2), single-marker analysis (SMA), interval mapping (IM) and composite interval mapping (CIM). All approaches yielded similar QTL detection results. Three QTLs are hypothesized for mortality (MORT=% dead cuttings), nine for adventitious rooting (ROOT, RCT=% rooted cuttings relative to the surviving or total cuttings, respectively), four for petrification (PETR=% surviving unrooted cuttings), one for sprouting ability (SPR=number of stump sprout cuttings harvested in 1995) and four for the stability of adventitious rooting (STAB=absolute value of the difference ROOT95-ROOT96). All putative QTLs for MORT and PETR were located on the E. tereticornis map, and for SPR and STAB on the E. globulus map. We found different QTLs for MORT, ROOT, RCT, SPR and STAB. Putative QTLs accounted for 2.6–17.0% of the phenotypic variance of a trait (R2). Estimated standardized gene substitution effects varied between 0.13 and 0.49 phenotypic standard deviations (σp). These results indicate that the phenotypic variation in these traits has a meaningful genetic component and that stable QTLs can be found in a family of reasonable size where no previous knowledge of the trait was available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051400
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  • 8
    Electronic Resource
    Electronic Resource
    Analysis of the deep chlorophyll maximum across the Azores Front (2000)
    Springer
    Hydrobiologia 441 (2000), S. 155-172 
    Details
    ISSN: 1573-5117
    Keywords: deep chlorophyll-a maximum ; primary production ; nutricline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Physical, chemical and biological observations made in late July and August 1997 across the Azores Front (37° N, 32°W to 32° N, 29°W) are presented. The objectives of the study were: (1) to analyse horizontal and vertical profiles of temperature, salinity, density, nutrients and chlorophyll-a (Chl a) of the top 350 m; (2) to identify the main differences in the deep Chl a Maximum (DCM) and hydrographic structure between the water masses that pass north and south of the Azores Front; and (3) to estimate phytoplankton primary production in these water masses. Horizontal and vertical profiles of salinity, temperature, density, nutrients and phytoplankton pigments in the top 350 m were analysed. The Front separates two distinct water types: the 18 °C Mode Water (18 MW) of sub-tropical origin, and the 15 °C Mode Water (15 MW) of sub-polar origin. Differences in the DCM and hydrographic structure between 18 MW and 15 MW were observed in the contour plots of each section. The average Chl a concentration between 5 and 200 m depth decreased significantly from 15 MW to 18 MW. The same pattern was observed for the Chl a concentration at the DCM depth. A vertical one-dimensional model was used to estimate the phytoplankton primary production in the 15 MW and 18 MW and led to an estimated water column average gross primary productivity (GPP) between 1.08 and 2.71 mg C m−3 d−1 for the 15 MW and about half of these values for the 18 MW. These results indicate that the typical south–north positive slope on DCM depth parallels a latitudinal increase on GPP, suggesting that the location of the Azores Front may have a significant regional impact on GPP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1017519330995
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  • 9
    Electronic Resource
    Electronic Resource
    A methodology for parameter estimation in seaweed productivity modelling (1993)
    Springer
    Hydrobiologia 260-261 (1993), S. 183-189 
    Details
    ISSN: 1573-5117
    Keywords: Parameter estimation ; productivity ; modelling ; growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This paper presents a combined approach for parameter estimation in models of primary production. The focus is on gross primary production and nutrient assimilation by seaweeds. A database of productivity determinations, biomass and mortality measurements and nutrient uptake rates obtained over one year for Gelidium sesquipedale in the Atlantic Ocean off Portugal has been used. Annual productivity was estimated by harvesting methods, and empirical relationships using mortality/wave energy and respiration rates have been derived to correct for losses and to convert the estimates to gross production. In situ determinations of productivity have been combined with data on the light climate (radiation periods, intensity, mean turbidity) to give daily and annual productivity estimates. The theoretical nutrient uptake calculated using a ‘Redfield ratio’ approach and determinations of in situ N and P consumption by the algae during incubation periods have also been compared. The results of the biomass difference and incubation approaches are discussed in order to assess the utility of coefficients determined in situ for parameter estimation in seaweed production models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00049018
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  • 10
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    Higgs sector of the supersymmetric reduced 331 model (2013)
    American Physical Society
    Details
    Publication Date: 2013-11-11
    Print ISSN: 1550-7998
    Electronic ISSN: 1550-2368
    Topics: Physics
    Published by American Physical Society
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