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  • 1
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    Biogeochemistry. Sulfate reducers--dominant players in a low-oxygen world? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-24
    Description: Sulfate reducing bacteria can adapt to extreme physical and chemical conditions and play an important role in global geochemical cycles, but their role in the formation of ore deposits has remained controversial. Strong support for such a role is provided by Labrenz et al., who have discovered sulfate-reducing bacteria that can tolerate low levels of oxygen and can precipitate zinc sulfide minerals. The results may have implications for bioremediation and may provide clues to processes that may have been more widespread in the geologic past.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vasconcelos, C -- McKenzie, J A -- New York, N.Y. -- Science. 2000 Dec 1;290(5497):1711-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geological Institute, Eidgen inverted question markssische Technische Hochschule-Zentrum, 8092 Z inverted question markrich, Switzerland. chris.vasconcelos@erdw.ethz.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11186393" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; *Biofilms/growth & development ; Calcium Carbonate/metabolism ; Chemical Precipitation ; Deltaproteobacteria/growth & development/*metabolism ; Geologic Sediments/*microbiology ; Magnesium/metabolism ; Oxidation-Reduction ; Oxygen/physiology ; Sulfates/*metabolism ; Sulfides/*metabolism ; Sulfur-Reducing Bacteria/growth & development/*metabolism ; Water Microbiology ; Zinc Compounds/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-07-23
    Description: Aberrant neovascularization contributes to diseases such as cancer, blindness and atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although many regulators of pathogenic angiogenesis have been identified, our understanding of this process is incomplete. Here we explore the transcriptome of retinal microvessels isolated from mouse models of retinal disease that exhibit vascular pathology, and uncover an upregulated gene, leucine-rich alpha-2-glycoprotein 1 (Lrg1), of previously unknown function. We show that in the presence of transforming growth factor-beta1 (TGF-beta1), LRG1 is mitogenic to endothelial cells and promotes angiogenesis. Mice lacking Lrg1 develop a mild retinal vascular phenotype but exhibit a significant reduction in pathological ocular angiogenesis. LRG1 binds directly to the TGF-beta accessory receptor endoglin, which, in the presence of TGF-beta1, results in promotion of the pro-angiogenic Smad1/5/8 signalling pathway. LRG1 antibody blockade inhibits this switch and attenuates angiogenesis. These studies reveal a new regulator of angiogenesis that mediates its effect by modulating TGF-beta signalling.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836402/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836402/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Xiaomeng -- Abraham, Sabu -- McKenzie, Jenny A G -- Jeffs, Natasha -- Swire, Matthew -- Tripathi, Vineeta B -- Luhmann, Ulrich F O -- Lange, Clemens A K -- Zhai, Zhenhua -- Arthur, Helen M -- Bainbridge, James W B -- Moss, Stephen E -- Greenwood, John -- 091886/Wellcome Trust/United Kingdom -- G0902206/Medical Research Council/United Kingdom -- G1000466/Medical Research Council/United Kingdom -- NIHR-RP-011-003/Department of Health/United Kingdom -- RG/12/2/29416/British Heart Foundation/United Kingdom -- British Heart Foundation/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2013 Jul 18;499(7458):306-11. doi: 10.1038/nature12345.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, UCL Institute of Ophthalmology, London EC1V 9EL, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23868260" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Endothelium, Vascular/cytology/*metabolism ; Glycoproteins/genetics/metabolism/*physiology ; In Vitro Techniques ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Transforming Growth Factor beta/metabolism ; Retinal Neovascularization/genetics/*metabolism ; Retinal Vessels/metabolism ; *Signal Transduction ; Transforming Growth Factor beta1/*metabolism/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Geochemistry. The descent of minerals (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vasconcelos, Crisogono -- McKenzie, Judith A -- New York, N.Y. -- Science. 2009 Jan 9;323(5911):218-9. doi: 10.1126/science.1168807.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geomicrobiology Laboratory of the Geological Institute, ETH-Zurich, 8092 Zurich, Switzerland. cris.vasconcelos@erdw.ethz.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19131619" target="_blank"〉PubMed〈/a〉
    Keywords: *Bacterial Physiological Phenomena ; Biochemical Processes ; Biological Evolution ; Biomass ; *Earth (Planet) ; *Evolution, Planetary ; *Geological Phenomena ; *Minerals
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Mass mortality and its environmental and evolutionary consequences (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-16
    Description: The latest Mesozoic and earliest Tertiary sediments at Deep Sea Drilling Project site 524 provide an amplified record of environmental and biostratographic changes at the end of Cretaceous. Closely spaced samples, representing time intervals as short as 10(2) or 10(3) years, were analyzed for their bulk carbonate and trace-metal compositions, and for oxygen and carbon isotopic compositions. The data indicate that at the end of Cretaceous, when a high proportion of the ocean's planktic organisms were eliminated, an associated reduction in productivity led to a partial transfer of dissolved carbon dioxide from the oceans to the atmosphere. This resulted in a large increase of the atmospheric carbon dioxide during the next 50,000 years, which is believed to have caused a temperature rise revealed by the oxygen-isotope data. The lowermost Tertiary sediments at site 524 include fossils with Cretaceous affinities, which may include both reworked individuals and some forms that survived for a while after the catastrophe. Our data indicate that many of the Cretaceous pelagic organisms became extinct over a period of a few tens of thousands of years, and do not contradict the scenario of cometary impact as a cause of mass mortality in the oceans, as suggested by an iridium anomaly at the Cretaceous-Tertiary boundary.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, K J -- He, Q -- McKenzie, J A -- Weissert, H -- Perch-Nielsen, K -- Oberhansli, H -- Kelts, K -- Labrecque, J -- Tauxe, L -- Krahenbuhl, U -- Percival, S F Jr -- Wright, R -- Karpoff, A M -- Petersen, N -- Tucker, P -- Poore, R Z -- Gombos, A M -- Pisciotto, K -- Carman, M F Jr -- Schreiber, E -- New York, N.Y. -- Science. 1982 Apr 16;216(4543):249-56.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17832725" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Characterization of environmental conditions during microbial Mg-carbonate precipitation and early diagenetic dolomite crust formation: Brejo do Espinho, Rio de Janeiro, Brazil (2015)
    Geological Society (of London)
    Details
    Publication Date: 2015-03-05
    Description: For many years, sedimentary dolomite rocks have been considered to be primarily a replacement product of the calcium carbonate components comprising the original limestone, a process known as secondary replacement dolomitization. Although numerous dolomite formations in the geological record are composed of fine-grained crystals of micritic dolomite, an alternative process, that is, direct precipitation, is often excluded because of the absence of visible or geochemical indicators supporting primary precipitation. In this research, we present a study of a modern coastal hypersaline lagoon, Brejo do Espinho, Rio de Janeiro State, Brazil, which is located in a special climatic regime where a well-defined seasonal cycle of wet and dry conditions occur. The direct precipitation of modern high-Mg calcite and Ca-dolomite mud from the lagoonal waters under low-temperature hypersaline conditions is associated with the activity of microbial organisms living in this restricted environment. The mud undergoes an early diagenetic transformation into a 100% dolomite crust on the margins of the lagoon. The biomineralization process, characterized by the variations of the physico-chemical conditions in this environment during the annual hydrological cycle, is integrated with isotopic analysis to define the early diagenetic processes responsible for the formation of both dolomitic mud and crust. The carbon isotope values indicate a contribution of respired organic carbon, which is greater for the crust ( 13 C=–9.5 Vienna Pee Dee Belemnite (VPDB)) than mud ( 13 C=–1.2 VPDB). The oxygen isotope values reflect a moderate degree of evaporation during mud formation ( 18 O=1.1 VPDB), whereas it is greatly enhanced during early diagenetic crust formation ( 18 O=4.2 VPDB). The clumped isotope formation temperature derived for the Brejo do Espinho mud is 34 °C, whereas it is 32 °C for the crust. These temperatures are consistent with the upper range of measured values during the dry season when the lagoon experiences the most hypersaline conditions.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
    Published by Geological Society (of London)
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  • 6
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    Preliminary isotopic and palaeomagnetic evidence for Younger Dryas and Holocene climate evolution in NE Asia (1997)
    In:  EPIC3Terra Nova, 9(5), pp. 246-250
    Details
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 7
    Electronic Resource
    Electronic Resource
    Selection for insecticide resistance in the Australian sheep blowfly,Lucilia cuprina (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 84-85 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Egg implant studies on sheep demonstrate that the relative fitness of resistance genotypes of the sheep blowfly,Lucilia cuprina, changes over time for the 2 insecticides dieldrin and diazinon. The results suggest that selection may occur following exposure of larvae to sub-lethal concentrations and help to explain the relative rates of the development of resistance to dieldrin and diazinon byL. cuprina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944541
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  • 8
    Electronic Resource
    Electronic Resource
    Ecological Genetics of Insecticide and Acaricide Resistance (1987)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 32 (1987), S. 361-380 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.en.32.010187.002045
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  • 9
    Electronic Resource
    Electronic Resource
    Preliminary isotopic and palaeomagnetic evidence for Younger Dryas and Holocene climate evolution in NE Asia (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Terra nova 9 (1997), S. 0 
    Details
    ISSN: 1365-3121
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Until recently the Younger Dryas cooling event was thought to be restricted to the North Atlantic region. However, preliminary evidence based on magnetic susceptibility and stable isotope data from Lake Hetongchahannor, a hypersaline alkaline lake in Inner Mongolia indicates that this event is observed in NE Asia. In addition we find indications of wetter climatic conditions between 9000 and 6000 yr BP, possibly due to increased monsoon activity, followed by a progressive aridification towards the present time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3121.1997.tb00022.x
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  • 10
    Electronic Resource
    Electronic Resource
    Mating patterns of virgin and inseminatedDrosophila melanogaster of different alcohol dehydrogenase (Adh) genotypes (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1160-1161 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Female choice mating experiments showed virgin femaleD. melanogaster of the 3Adh genotypes chose heterozygous (Adh F /Adh S ) males most commonly. Inseminated females chose mates randomly, but the likelihood of a female remating was genotypically dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01976099
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