ISSN:
1434-1948
Keywords:
Conjugate addition
;
Enones
;
Steroids
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The transmetallation of arylmagnesium halides or aryllithium with Me2AlCl results in the formation of aryldimethylaluminum compounds. These arylaluminum compounds are useful reagents for conjugate additions to enones in the presence of Ni(acac)2 as a catalyst. 3-Aryl ketones are obtained in good yields in these catalytic reactions. Starting from the 3-oxo-Δ1,4-steroids this method gives access to 1α-arylsteroids.
Type of Medium:
Electronic Resource
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