Publication Date:
2001-10-06
Description:
We synthesized multimetal microrods intrinsically encoded with submicrometer stripes. Complex striping patterns are readily prepared by sequential electrochemical deposition of metal ions into templates with uniformly sized pores. The differential reflectivity of adjacent stripes enables identification of the striping patterns by conventional light microscopy. This readout mechanism does not interfere with the use of fluorescence for detection of analytes bound to particles by affinity capture, as demonstrated by DNA and protein bioassays.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicewarner-Pena, S R -- Freeman, R G -- Reiss, B D -- He, L -- Pena, D J -- Walton, I D -- Cromer, R -- Keating, C D -- Natan, M J -- HG02228/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2001 Oct 5;294(5540):137-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA., SurroMed Inc., 2375 Garcia Avenue, Mountain View, CA 94043, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11588257" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biochemistry/*methods
;
Chemistry Techniques, Analytical/*methods
;
Electrochemistry
;
Fluorescence
;
Fluorescent Antibody Technique
;
Humans
;
Immunoassay/*methods
;
Immunoglobulin G/analysis
;
*Metals
;
Microscopy
;
Miniaturization
;
Nucleic Acid Hybridization/*methods
;
Oligonucleotide Probes
;
Optics and Photonics
;
Rabbits
;
Templates, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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