ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In this study, such behaviors of vascular smooth muscle cells (VSMCs), as proliferationand migration, with serum stimulation were investigated onto (−)-epigallocatechin-3-O-gallate(EGCG)-blended poly(L-lactide-co-ε-caprolactone, PLCL) copolymers (EGCG-b PLCL). VSMCswere primarily cultured from rat aorta, and EGCG-b PLCL films were fabricated by mixing PLCLwith EGCG. The proliferation of VSMCs cultured onto EGCG-b PLCL film was significantlysuppressed in spite of serum induction. Moreover, recovery of denuded area by VSMCs receivingconditioned media obtained from EGCG-b films was completely inhibited, whereas VSMCs ontointact films migrated into denuded area in response to serum showing essentially complete recovery.These results suggest that inhibition in the behaviors of serum-stimulated VSMCs may be mediatedthrough the anti-proliferative effects of EGCG released from polymer films, and EGCG-b polymerscan be applied for fabricating an EGCG-eluting vascular stent
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.189.pdf
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