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  • 1
    Electronic Resource
    Electronic Resource
    Studies of the influences of pregnancy and lactation on the thymus in the mouse (1962)
    Springer
    Cell & tissue research 57 (1962), S. 667-678 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Influences of pregnancy and lactation on the thymus were quantitatively and microscopically studied in the mouse. Thytnic involution due to pregnancy occurs in later pregnancy and reaches a maximum at parturition. After parturition the involuted thymus regenerates, but lactation has an inhibitory influence on the regeneration. The possible significance of the thymic changes is discussed particularly in relation to the adrenocortical activity. Histologically the cortex exhibits prominent alterations during the involution and regeneration. The pattern of depletion and repopulation of lymphocytes in the cortex is similar to that in other types of acute involution. The medulla also undergoes microscopic changes which are revealed particularly by the histometric examination of its components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410229
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  • 2
    Electronic Resource
    Electronic Resource
    Electron microscopic studies of the epithelial reticular cells of the mouse thymus (1963)
    Springer
    Cell & tissue research 59 (1963), S. 513-529 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopic studies have been made of the epithelial reticular cells of the thymus in mice of both sexes ranging in age from 5 to 8 weeks. The epithelial cells generally have long cytoplasmic processes by which they are interconnected and form a network throughout the organ. The processes adhere tightly to one another by desmosomes. At the surface of the organ the processes constitute a thin sheet, and a basement membrane is discernible close and parallel to the free surface of the epithelial sheet. In the cortex the meshes of the epithelial reticulum are filled with numerous lymphoid cells and relatively few mesenchymal reticular cells. The epithelial cells in the cortex are characterized by their slender cytoplasmic processes and by the presence of large round vesicles which contain coarsely granulated, dense material. By the presence of the vesicles as well as desmosomes at junctions of the cytoplasmic processes the epithelial cells can be distinguished from other cells. For comparison the cytological characteristics of the mesenchymal reticular cells are also described. In the medulla two types — reticular and hypertrophic — of epithelial cells are recognized. The cells of reticular type are irregularly stellated in shape with extended cytoplasmic processes. Their cytoplasm often contains considerable amounts of fine filaments in bundles. Due to the relative abundance of free ribonucleoprotein particles and other cytoplasmic components, the cytoplasm appears relatively electronopaque as compared with that of the cells of the other type. The plasma membrane of the cells of reticular type sometimes invaginates into the cytoplasm to enclose a lumen which contains substance of low density and sometimes fine filaments. A basement membrane-like layer is discernible close to the infolded plasma membrane in the lumen. The cells of hypertrophic type are relatively large and round with a few shorter cytoplasmic processes. They are characterized by the abundance of the smooth endoplasmic reticulum which appears as vesicle or sac of small size. These cells often possess peculiar vesicles the wall of which is provided with microvilli projecting into the lumen. Some of these vesicles carry cilia on their wall in addition to the microvilli. The cells of hypertrophic type often undergo degeneration. The degenerating cells are concentrically surrounded by a few neighboring cells of both hypertrophic and reticular types, and Hassall's corpuscles are formed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368725
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  • 3
    Electronic Resource
    Electronic Resource
    Microfibrils: a constitutive component of reticular fibers in the mouse lymph node (1990)
    Springer
    Cell & tissue research 262 (1990), S. 199-201 
    Details
    ISSN: 1432-0878
    Keywords: Microfibrils ; Elastic fibers ; Reticular fibers ; Lymph node ; Tannic acid-uranyl acetate staining ; Mouse bgJ/bgJ-C57BL/6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fibrous components other than collagen fibrils in the reticular fiber of mouse lymph node were studied by electron microscopy. Bundles of microfibrils not associated by elastin and single microfibrils dispersed among collagen fibrils were present. The diameter of the microfibrils was 13.29±2.43 nm (n=100). Elastin-associated microfibrils occurred at the periphery of the reticular fiber. Elastin was enclosed by microfibrils, thus forming the elastic fiber, which was clearly demonstrated by tannic acid-uranyl acetate staining. In the reticular fiber of lymph nodes, the elastic fiber consisted of many more microfibrils and a small amount of elastin. These microfibrils, together with the collagen fibrils, may contribut to the various functions of the reticular fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327763
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural study of a cytoplasmic bridge connecting a pair of erythroblasts in mice (1991)
    Springer
    Cell & tissue research 264 (1991), S. 215-219 
    Details
    ISSN: 1432-0878
    Keywords: Erythroblast ; Cytokinesis ; Cytoplasmic bridge ; Fetal liver ; Erythropoiesis ; Electron microscopy ; dd Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A unique cytoplasmic connection between erythroblasts was studied by electron microscopy in mouse hemopoietic tissues (fetal liver, fetal and neonatal spleen and adult bone marrow). Many pairs of interphase erythroblasts were connected by a “cytoplasmic bridge” that was very thin and sometimes long in comparison with telophase bridges. The stage of maturation of the cells in a pair was similar. Small numbers of microtubules ran along the cytoplasmic bridge; a mid-body was not seen. The plasma membrane at approximately the middle of the bridge bulged to form a ring-shaped ridge filled with dense amorphous substances; this was called a “bulging ring”. Thus, the cytoplasmic bridge between erythroblasts did not morphologically correspond to the telophase bridge in the usual cytokinesis. Cytoplasmic bridges were observed in various differentiating stages of erythroblasts, whereas other cell types of the hemopoietic lineage did not have such a bridge. The cytoplasmic bridge is unique to erythroblasts and provides an evidence for the atypical cytokinesis of the erythroblastic lineage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313958
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  • 5
    Electronic Resource
    Electronic Resource
    Histological changes of the mouse thymus during involution and regeneration following administration of hydrocortisone (1962)
    Springer
    Cell & tissue research 56 (1962), S. 445-464 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A histological study has been made of the thymus in mice during acute involution and regeneration following administration of hydrocortisone. The cortex undergoes remarkable changes in the microscopic structure during involution and regeneration. During involution the lymphocytes in the cortex rapidly decrease and are removed. Then a rapid replacement of lymphocytes occurs during regeneration. On the basis of formation and repopulation of lymphocytes the regenerative process of the cortex is divided into seven phases. The reconstitution of the cortex proceeds more rapidly in females than in males. Newly formed lymphocytes take origin from the mesenchymal cells in the cortex. Such mesenchymal cells become distinguishable from epithelial reticular cells during involution. They appear to engulf destroyed lymphocytes and debris during involution and then transform into immature lymphoid cells during early regeneration. The findings may support the recent reutilization concept that destroyed lymphocytes are phagocytized and reutilized by reticular cells in heteroplastic differentiation into immature lymphoid cells. In the cortex PAS-positive sudanophilic cells which are derived from the perivascular and subcapsular connective tissue appear with involutionary changes. They become gradually reduced again with progress of the regeneration of the cortex. During involution the medulla are temporarily filled with lymphocytes migrated from the cortex. The epithelial reticular cells in the medulla are found grouped in cords or clumps in the severely involuted thymus. In the medulla there are two types of PAS-positive epithelial reticular cells; one contains a large, colloid-like, PAS-positive inclusion within the cytoplasm and the other has cytoplasm diffusely filled with PAS-positive substance. During involution and early regeneration, the former type increases while the other shows almost no significant changes. Hassall's corpuscles somewhat increase in frequency during involution and early regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335625
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  • 6
    Electronic Resource
    Electronic Resource
    Avian epidermis contains ATPase- and Ia-positive Langerhans-like cells (1993)
    Springer
    Cell & tissue research 271 (1993), S. 103-106 
    Details
    ISSN: 1432-0878
    Keywords: Skin ; Langerhans cell ; ATPase-histochemistry ; Ultrastructure ; Ia antigen ; Four avian species
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The occurrence of cells resembling mammalian Langerhans cells in the avian epidermis was studied by ATPase histochemistry, Ia immunoreactivity and electron microscopy. The existence of MHC class II antigen-(Ia) expressing, ATPase-positive dendritic cells, which are ultrastructurally similar to mammalian Langerhans cells except for the absence of Birbeck granules, was demonstrated. These cells may be a basic component of the immune system of birds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297547
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  • 7
    Electronic Resource
    Electronic Resource
    Development of ATPase-positive, immature Langerhans cells in the fetal mouse epidermis and their maturation during the early postnatal period (1987)
    Springer
    Cell & tissue research 248 (1987), S. 315-322 
    Details
    ISSN: 1432-0878
    Keywords: Langerhans cell ; ATPase ; Epidermal differentiation ; Cellular maturation ; Fetal mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development and maturation of Langerhans cells during the differentiation of skin was studied in mice from fetal day 13 to adult using 3 indices: (1) ATPase activity; (2) ultrastructure; and (3) quantitative evaluation of the cell population. ATPase-positive Langerhans cells appeared in the epidermis at first at fetal day 16, and they increased in number in the differentiating epidermis during the late fetal period. The earliest appearance of Birbeck granules was at postnatal day 4. Cored tubules were also formed in the Langerhans cells in the dermis at around the same age. The cells containing Birbeck granules or cored tubules are considered to be mature Langerhans cells. In the Langerhans-cell lineage, those cells in the epidermis at stages earlier than postnatal day 4 and not yet containing specific organelles are considered to be immature Langerhans cells. These immature Langerhans cells can be identified ultrastructurally in the epidermis at fetal day 16, coinciding with the appearance of ATPase-positive cells. The increase in the number of immature Langerhans cells during the perinatal period was shown by quantitative analysis of nuclear density and relative Langerhans-cell area on the electron micrographs. It is concluded that ATPase is a marker of the Langerhans-cell lineage from the early development stages, while Birbeck granules and cored tubules are markers that identify mature Langerhans cells in electron micrographs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218198
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  • 8
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    Metabolically active microbial communities in marine sediment under high-CO2 and low-pH extremes (2013)
    Springer Nature
    Details
    Publication Date: 2013-02-20
    Description: Metabolically active microbial communities in marine sediment under high-CO2 and low-pH extremes The ISME Journal 7, 555 (March 2013). doi:10.1038/ismej.2012.124 Authors: Katsunori Yanagawa, Yuki Morono, Dirk de Beer, Matthias Haeckel, Michinari Sunamura, Taiki Futagami, Tatsuhiko Hoshino, Takeshi Terada, Ko-ichi Nakamura, Tetsuro Urabe, Gregor Rehder, Antje Boetius & Fumio Inagaki
    Keywords: CO2 seeplow pHanaerobic oxidation of methaneacidophilic sulfate reduction
    Print ISSN: 1751-7362
    Electronic ISSN: 1751-7370
    Topics: Biology
    Published by Springer Nature on behalf of The International Society for Microbial Ecology (ISME).
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  • 9
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    Microfibrils: a constitutive component of reticular fibers in the mouse lymph node (1990)
    Springer
    Details
    Publication Date: 1990-10-01
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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  • 10
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    Studies of the influences of pregnancy and lactation on the thymus in the mouse (1962)
    Springer
    Details
    Publication Date: 1962-01-01
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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