ISSN:
1432-0983
Keywords:
Key words Mitochondria
;
Transcription regulation
;
PEL1/PGS1
;
Phospholipid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The PEL1/PGS1 gene of the yeast Saccharomyces cerevisiae is essential for the viability of rho –/rho° mutants and the normal cardiolipin content of cells. The PEL1-GFP fusion gene has been found to complement the pel1/pgs1 mutation and its fluorescent protein was localized to mitochondria similarly to the β-galactosidase activity of a protein encoded by the PEL1-lacZ fusion gene. The expression of the PEL1-lacZ reporter gene was repressed in cells grown in the presence of inositol and choline, reduced in the ino2 and ino4 strains, but constitutive in the opi1 null-mutant strain. The results demonstrate that Pel1p, playing a vital role in cells impaired in the mitochondrial DNA, is localized in the mitochondria and expressed in response to inositol and choline.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002940050399
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