ISSN:
1432-1432
Keywords:
DNA evolution
;
ZFY
;
Divergence
;
Polymerase chain reaction
;
Sex determination
;
Zinc fingers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary We report the isolation and nucleotide sequence determination of clones derived from five ZFY-related zinc-finger genes from birds and mammals. These sequences are analyzed with reference to the previously published human genes, ZFX and ZFY, and mouse genes, Zfx, Zfa, Zfy-1, and Zfy-2. The analysis indicates that ZFY-related genes are highly conserved in birds and mammals, and that the rate of nucleotide substitution in the Y-linked genes is not as high as predicted. However, the mouse Zfy-1 and Zfy-2 genes are markedly divergent members of the ZFY gene family; we suggest this relates to X-inactivation of the mouse gene Zfx.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02102189
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