ISSN:
1042-7163
Keywords:
Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In this article, it is reported that the isomerization/chlorination reactions of nitrogen heterocyclic O,O-dialkyl thiophosphoramidates 5 with equivalent amounts of phosphorus oxychloride give nitrogen heterocyclic S-alkyl thiophosphorochloridates 6 and O-alkyl phosphorodichloridates 3. After removal of the by-products 3 under reduced pressure, the crude products 6 are directly reacted with various nucleophiles, NuH, in the presence of triethylamine to give nitrogen heterocyclic S-alkyl thiophosphoramidic acid derivatives 7. Thus, a new convenient method has been provided for the synthesis of the title compounds. © 1996 John Wiley & Sons, Inc.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
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