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  • 1
    Publication Date: 2022-05-27
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Brun, N. R., Panlilio, J. M., Zhang, K., Zhao, Y., Ivashkin, E., Stegeman, J. J., & Goldstone, J. Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Communications Biology, 4(1), (2021): 1129, https://doi.org/10.1038/s42003-021-02626-9.
    Description: The most abundant polychlorinated biphenyl (PCB) congeners found in the environment and in humans are neurotoxic. This is of particular concern for early life stages because the exposure of the more vulnerable developing nervous system to neurotoxic chemicals can result in neurobehavioral disorders. In this study, we uncover currently unknown links between PCB target mechanisms and neurobehavioral deficits using zebrafish as a vertebrate model. We investigated the effects of the abundant non-dioxin-like (NDL) congener PCB153 on neuronal morphology and synaptic transmission linked to the proper execution of a sensorimotor response. Zebrafish that were exposed during development to concentrations similar to those found in human cord blood and PCB contaminated sites showed a delay in startle response. Morphological and biochemical data demonstrate that even though PCB153-induced swelling of afferent sensory neurons, the disruption of dopaminergic and GABAergic signaling appears to contribute to PCB-induced motor deficits. A similar delay was observed for other NDL congeners but not for the potent dioxin-like congener PCB126. The effects on important and broadly conserved signaling mechanisms in vertebrates suggest that NDL PCBs may contribute to neurodevelopmental abnormalities in humans and increased selection pressures in vertebrate wildlife.
    Description: This work was supported by the Swiss National Science Foundation P2EZP2_165200 (NRB), the Boston University Superfund Research Program NIH 5P42ES007381 (J.J.S. and J.V.G.), the Woods Hole Center for Oceans and Human Health (NIH: P01ES021923 and P01ES028938; NSF: OCE-1314642 and OCE-1840381) (N.R.B., J.M.P., and J.J.S.), and the National Natural Science Foundation of China 22006099 (K.Z. and Y.Z.) and the Shanghai Pujiang Program 19PJ1404900 (K.Z. and Y.Z.).
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Publication Date: 2023-05-20
    Description: The discovery and large-scale exploration of deep basin oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology. It has not only changed the balance of supply and demand in the global energy market, but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs. However, misconceptions widely exist in studies of different types of petroleum accumulations because of the lack of a unified genetic classification. Unconventional reservoir has been used in the literature as a general name for various oil/gas reservoirs that are formed under complex dynamic mechanisms as long as buoyancy is not the major controlling factor. On the other hand, different terms have been given to the reservoirs even with the same formation mechanism. This paper studies the progress of unconventional oil/gas exploration in North America in the past 30 years, analyzes the drilling results of 80762 reservoir layers from 12237 exploration wells in six representative basins in China and the discovered 52,926 oil/gas reservoirs in 1,186 basins around the world, and reviews the classification schemes about oil/gas reservoirs by different scholars. It is found that there are five differences between conventional and unconventional reservoirs, including hydrocarbon composition, spatial relation with source rocks, reservoir lithology and quality, distribution in geological settings, and reservoir formation mechanism. Meanwhile,it is also found that there are five aspects of relevance among them, including petroleum source, distribution in strata within the same geological age, coexisting in sedimentary basins, in petroleum systems, and in target reservoir layers. A unified genetic classification scheme about conventional and unconventional oil/gas reservoirs was introduced based on clarifying their differences, correlations and formation mechanisms. All petroleum reservoirs are classified into 3 categories and 6 subcategories according to dynamic mechanisms of formation, reclassified into 15 types based on main controlling factors, and further divided into 49 styles considering their underground occurrences. The application results show that all different oil/gas reservoirs can find their corresponding positions in the classification scheme, and all the oil/gas reservoirs with the same genetic mechanism, major controlling factor and occurrence can find their particular position in this classification scheme.
    Keywords: Binary Object; Binary Object (File Size); Binary Object (Media Type); China; Conventional and Unconventional Reservoirs; Fossil Energy; Hydrocarbon Accumulations; Nature Energy; Oil/gas Reservoirs Classification.; Petroleum Resources
    Type: Dataset
    Format: text/tab-separated-values, 12 data points
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  • 3
    Publication Date: 2023-06-24
    Description: Geological and geochemical data of 13634 source rock samples from 1286 exploration wells in six representative petroliferous basins are examined to study their Active Source Rock Depth Limits (ASDL). Active source rocks and the discovered 21.6 billion tons of reserves in six representative basins in China and 52926 oil and gas reservoirs in the 1186 basins over the world are found to be distributed above the ASDL, illustrating the universality of such kind of depth limit.
    Keywords: Active source rock depth limit; China_basins; Conventional and unconventional hydrocarbons; MULT; Multiple investigations; source rock
    Type: Dataset
    Format: application/zip, 3 MBytes
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 873-876 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Applied mechanics and materials Vol. 10-12 (Dec. 2007), p. 364-368 
    ISSN: 1662-7482
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper introduces the characteristics and general laws of cutting complex curvedsurface by Wire-cut Electric Discharge Machining (WEDM) system. Taking the three-axle anddouble-rotating linkage system as an example, the universal mathematical model of polarcoordinates is derived. Moreover, the simulation of WEDM system is introduced, which utilizinglanguage Visual C++ and the three dimensional graph software OpenGL.This simulation method ishelpful in improving machining quality and productivity of complex curved surfaces, and isfundation for establishing CAD/CAPP/CAM technology in WEDM
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 118 (Dec. 2006), p. 243-246 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: novel duplex coating is presented on steel substrate by laser discrete quenching prior tochromium coating deposition. Due to the periodical changes in the mesostructures and properties ofunderlying substrate, the cracking and spalling behaviors of the duplex coating are expected to bedifferent from that of conventional coating. A classic erosion experiment is selected to characterizethe positive response of the duplex coating subjected to thermal loads. It is found that the surfacecracking is partly restrained and the interface cracking is partly arrested. FEM modeling resultsshow that a unique stress state is induced in the duplex coating with the tempering of the discretepre-quenched regions due to thermal loading, which is believed to be the mechanism of controllingthe damage modes
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 680-686 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Genome sequencing currently requires DNA from pools of numerous nearly identical cells (clones), leaving the genome sequences of many difficult-to-culture microorganisms unattainable. We report a sequencing strategy that eliminates culturing of microorganisms by using real-time isothermal ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 38 (2006), S. 382-387 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We report a method for multilocus long-range haplotyping on human chromosome molecules in vitro based on the DNA polymerase colony (polony) technology. By immobilizing thousands of intact chromosome molecules within a polyacrylamide gel on a microscope slide and performing multiple amplifications ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 1749-1752 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The evaluation of the interfacial adhesion of coating system has always been a rough task.In this paper, a special testing method of cross-sectional indentation is applied on a model coatingsystem, i.e. electroplated chromium on a steel substrate which is generally regarded as an exampleof materials pair with strong adhesion. Based on fractography analysis with SEM and interfacialstress simulation with FEM, it is found that interfacial shear stress may induce coating spalling.More interestingly, spalling location is sensitive to substrate pretreatment process. This shows thefeasibility of cross-sectional indentation to distinguish interfacial strength at a high level
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1042-7163
    Keywords: Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new method for the synthesis of S-alkyl methylthiophosphonic acid derivatives is reported. The chlorination of 0,0-dialkyl methylthiophosphonates 8 with phosphorus oxychloride proceeds with isomerization of the P=S to the P-S bond to give S-alkyl methylthiophosphonochloridates 9, which react further with various nucleophiles in the presence of triethylamine to afford S-alkyl methylthiophosphonic acid derivatives 10. Among them, several compounds 10 show excellent fungicidal or insecticidal activities. © 1995 John Wiley & Sons, Inc.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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