Publication Date:
2015-03-29
Description:
Article Basal-like breast cancer is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. Here the authors provide evidence that ID4 is a key controller of mammary stem/progenitor cell self-renewal, acting upstream of Notch signalling to repress luminal fate commitment. Nature Communications doi: 10.1038/ncomms7548 Authors: Simon Junankar, Laura A. Baker, Daniel L. Roden, Radhika Nair, Ben Elsworth, David Gallego-Ortega, Paul Lacaze, Aurélie Cazet, Iva Nikolic, Wee Siang Teo, Jessica Yang, Andrea McFarland, Kate Harvey, Matthew J. Naylor, Sunil R. Lakhani, Peter T. Simpson, Ashwini Raghavendra, Jodi Saunus, Jason Madore, Warren Kaplan, Christopher Ormandy, Ewan K. A. Millar, Sandra O’Toole, Kyuson Yun, Alexander Swarbrick
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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