Publication Date:
2018-10-16
Description:
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference, Published online: 15 October 2018; doi:10.1038/s41467-018-05892-0 Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics