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  • 1
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    Sequence interpretation. Functional annotation of mouse genome sequences (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, J H -- Balling, R -- Barsh, G -- Beier, D -- Brown, S D -- Bucan, M -- Camper, S -- Carlson, G -- Copeland, N -- Eppig, J -- Fletcher, C -- Frankel, W N -- Ganten, D -- Goldowitz, D -- Goodnow, C -- Guenet, J L -- Hicks, G -- Hrabe de Angelis, M -- Jackson, I -- Jacob, H J -- Jenkins, N -- Johnson, D -- Justice, M -- Kay, S -- Kingsley, D -- Lehrach, H -- Magnuson, T -- Meisler, M -- Poustka, A -- Rinchik, E M -- Rossant, J -- Russell, L B -- Schimenti, J -- Shiroishi, T -- Skarnes, W C -- Soriano, P -- Stanford, W -- Takahashi, J S -- Wurst, W -- Zimmer, A -- International Mouse Mutagenesis Consortium -- New York, N.Y. -- Science. 2001 Feb 16;291(5507):1251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, BRB 624, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. jhn4@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11233449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Computational Biology ; Costs and Cost Analysis ; Genes/physiology ; Genetic Techniques ; *Genome ; *Genomics ; International Cooperation ; Mice/*genetics ; Mutagenesis ; Mutation ; Phenotype ; Private Sector ; Public Sector ; Research Support as Topic ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A genomic-systems biology map for cardiovascular function (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-11-27
    Description: With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stoll, M -- Cowley, A W Jr -- Tonellato, P J -- Greene, A S -- Kaldunski, M L -- Roman, R J -- Dumas, P -- Schork, N J -- Wang, Z -- Jacob, H J -- 1P50-HL-54998/HL/NHLBI NIH HHS/ -- R01 HL064541/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1723-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Bioinformatics Research Center, and, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721057" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects/genetics ; *Cardiovascular Physiological Phenomena/drug effects ; Chromosome Mapping/*methods ; Chromosomes/genetics ; Crosses, Genetic ; Female ; Genomics/*methods ; Humans ; Kidney/physiology ; Lod Score ; Male ; Nitric Oxide Synthase/genetics ; Norepinephrine/pharmacology ; Phenotype ; Quantitative Trait, Heritable ; Rats ; Vasodilation/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Knockout rats via embryo microinjection of zinc-finger nucleases (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-25
    Description: The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. By using engineered zinc-finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38, we demonstrate that a single injection of DNA or messenger RNA encoding ZFNs into the one-cell rat embryo leads to a high frequency of animals carrying 25 to 100% disruption at the target locus. These mutations are faithfully and efficiently transmitted through the germline. Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831805/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831805/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geurts, Aron M -- Cost, Gregory J -- Freyvert, Yevgeniy -- Zeitler, Bryan -- Miller, Jeffrey C -- Choi, Vivian M -- Jenkins, Shirin S -- Wood, Adam -- Cui, Xiaoxia -- Meng, Xiangdong -- Vincent, Anna -- Lam, Stephen -- Michalkiewicz, Mieczyslaw -- Schilling, Rebecca -- Foeckler, Jamie -- Kalloway, Shawn -- Weiler, Hartmut -- Menoret, Severine -- Anegon, Ignacio -- Davis, Gregory D -- Zhang, Lei -- Rebar, Edward J -- Gregory, Philip D -- Urnov, Fyodor D -- Jacob, Howard J -- Buelow, Roland -- 5P01HL082798-03/HL/NHLBI NIH HHS/ -- 5U01HL066579-08/HL/NHLBI NIH HHS/ -- P01 HL082798/HL/NHLBI NIH HHS/ -- P01 HL082798-03/HL/NHLBI NIH HHS/ -- U01 HL066579/HL/NHLBI NIH HHS/ -- U01 HL066579-08/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 24;325(5939):433. doi: 10.1126/science.1172447.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 52336, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19628861" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Dna ; Embryo, Mammalian ; Endodeoxyribonucleases/genetics/*metabolism ; Feasibility Studies ; Female ; *Gene Knockout Techniques ; Green Fluorescent Proteins ; Immunoglobulin M/*genetics ; Male ; *Microinjections ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; RNA, Messenger ; Rats ; *Zinc Fingers/genetics ; rab GTP-Binding Proteins/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Colonization behaviour of two enterobacterial strains on cereals (2000)
    Springer
    Biology and fertility of soils 30 (2000), S. 550-557 
    Details
    ISSN: 1432-0789
    Keywords: Key words Bacteria-plant interaction ; Pantoea agglomerans ; Klebsiella pneumoniae ; Double antibody sandwich enzyme linked immunosorbent assay ; Population densities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  Two diazotrophic enterobacterial strains, Pantoea agglomerans D5/23 and Klebsiella pneumoniae CC12/12, were observed in sterile and non-sterile hydroponic and soil experiments in order to determine, by means of an immunological detection method (double antibody sandwich enzyme linked immunosorbent assay), their colonization sites, their migration within individuals of different plant species, and their ability to compete with indigenous organisms. To investigate the interaction between bacteria and plants, root and shoot samples were analysed using electron microscopy. Field experiments were performed to determine the growth-promoting abilities of the bacterial strains. In field experiments, inoculation with P. agglomerans led to an increase in the grain yield of different wheat (Triticum aestivum) cultivars. The same strain was also able to colonize the rhizosphere and the phyllosphere of different cereals due to its ability to migrate within the plant. Roots and media were colonized 10–100 times more intensively than shoots, with about 106 cells g–1 root and 104 cells g–1 shoot. We found that P. agglomerans colonized the root and plant-growth medium of wheat to a greater extent than those of rye (Secale cereale) and barley (Hordeum vulgare), whereas the colonization of shoots was higher in rye and barley compared to wheat. Furthermore, while cell numbers of K. pneumoniae in media and roots were 10 times higher than cell numbers of P. agglomerans, only the latter markedly increased root growth. We were able to detect significant differences in colonization numbers between treatments even if the data were not normally or log-normally distributed or the variances were not homogenous.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003740050035
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  • 5
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Entwicklung der Brustwand beim Hühnerembryo (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 1449-1451 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The origin of the ribs and the thoracic muscles has been studied by using the quail-chick marker system. The results have shown that cells of somite origin give rise to both vertebral and sternal rib components. It was concluded that the muscles of the thorax, including the pectoral musculature, originate from the somites, whereas the lateral plate mesoderm is the source of the connective tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01919689
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  • 6
    Electronic Resource
    Electronic Resource
    Über den Ursprung der Flügelmuskulatur. Experimentelle Untersuchungen mit Wachtel- und Hühnerembryonen (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 1446-1449 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The origin of the wing bud mesenchyme of chick embryos has been studied by using the quail-chick marker system. It was concluded that the lateral plate mesoderm gives rise to the skeleton and connective tissue, whereas the muscles originate from cells of the somite mesoderm. It was suggested that these cells migrate into the prospective wing bud mesoderm before stage 15 (Hamburger andHamilton).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01919688
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  • 7
    Electronic Resource
    Electronic Resource
    Die frühe Differenzierung des chordanahen Bindegewebes. Raster- und transmissionselektronenmikroskopische Untersuchungen an Hühnerembryonen (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1083-1086 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The early differentiation of the connective tissue was investigated in the perinotochordal zone of 2–3 day-old chick embryos. After characterizing the different tissue components by transmission electron microscopy, their arrangement and distribution were examined by SEM. The results are discussed with regard to the role of the extracellular material in embryonic tissue interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326973
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  • 8
    Electronic Resource
    Electronic Resource
    An experimental study on the relative distribution of the somitic and somatic plate mesoderm to the abdominal wall of avian embryos (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 241-242 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The origin of the structures of the abdominal wall in avian embryos was studied by using the quail-chick marker system. It was concluded that the muscles originate from somitic cells while tendons, fasciae and the intramuscular fibroblasts, as also the remaining connective tissue, derive from the somatic plate mesoderm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944704
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  • 9
    Electronic Resource
    Electronic Resource
    Differentiating abilities of avian somatopleural mesoderm (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1376-1378 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Quail-to-chick grafting experiments were performed on 2-day embryos in order to test the differentiating abilities of the somatopleure. After orthotopic and heterotopic transplantations of different parts of quail somatopleural mesoderm into chick embryos it is demonstrated that avian somatopleural cells differentiate into skeletal elements, smooth muscles, tendons and connective tissues. However, skeletal muscle fibres do not originate from somatopleural cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964018
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  • 10
    Electronic Resource
    Electronic Resource
    On the formation of the myotomes in avian embryos. An experimental and scanning electron microscope study (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 893-893 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939687
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