ISSN:
1573-1375
Keywords:
genetic linkage
;
graphical models
;
Markov chain Monte Carlo
;
peeling
Source:
Springer Online Journal Archives 1860-2000
Topics:
Computer Science
,
Mathematics
Notes:
Abstract The problem of multilocus linkage analysis is expressed as a graphical model, making explicit a previously implicit connection, and recent developments in the field are described in this context. A novel application of blocked Gibbs sampling for Bayesian networks is developed to generate inheritance matrices from an irreducible Markov chain. This is used as the basis for reconstruction of historical meiotic states and approximate calculation of the likelihood function for the location of an unmapped genetic trait. We believe this to be the only approach that currently makes fully informative multilocus linkage analysis possible on large extended pedigrees.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008947712763
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