Publication Date:
1985-11-29
Description:
Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin-releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woloski, B M -- Smith, E M -- Meyer, W J 3rd -- Fuller, G M -- Blalock, J E -- AI 18932/AI/NIAID NIH HHS/ -- IR01AM338-39-01A1/AM/NIADDK NIH HHS/ -- R01-H120201/PHS HHS/ -- New York, N.Y. -- Science. 1985 Nov 29;230(4729):1035-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2997929" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Glands/metabolism
;
Adrenocorticotropic Hormone/*secretion
;
Animals
;
Interleukin-1/pharmacology
;
Interleukin-6
;
Mice
;
Monocytes/*physiology
;
Monokines
;
Pituitary-Adrenal System/*physiology
;
Proteins/*pharmacology
;
Secretory Rate/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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