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Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis (2007)

V. V. Lunyak ; G. G. Prefontaine ; E. Nunez ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 317(5835): 248-51. doi: 10.1126/science.1140871.

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Publication Date: 2007-07-14

Description: The temporal and spatial regulation of gene expression in mammalian development is linked to the establishment of functional chromatin domains. Here, we report that tissue-specific transcription of a retrotransposon repeat in the murine growth hormone locus is required for gene activation. This repeat serves as a boundary to block the influence of repressive chromatin modifications. The repeat element is able to generate short, overlapping Pol II-and Pol III-driven transcripts, both of which are necessary and sufficient to enable a restructuring of the regulated locus into nuclear compartments. These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lunyak, Victoria V -- Prefontaine, Gratien G -- Nunez, Esperanza -- Cramer, Thorsten -- Ju, Bong-Gun -- Ohgi, Kenneth A -- Hutt, Kasey -- Roy, Rosa -- Garcia-Diaz, Angel -- Zhu, Xiaoyan -- Yung, Yun -- Montoliu, Lluis -- Glass, Christopher K -- Rosenfeld, Michael G -- New York, N.Y. -- Science. 2007 Jul 13;317(5835):248-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093-0648, USA. vlunyak@uscd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17626886" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; Base Sequence ; Chromatin Immunoprecipitation ; DNA Polymerase II/metabolism ; DNA Polymerase III/metabolism ; *Gene Expression Regulation, Developmental ; Growth Hormone/*genetics ; Histones/metabolism ; *Insulator Elements ; Methylation ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; *Organogenesis ; Pituitary Gland/*embryology/metabolism ; *Short Interspersed Nucleotide Elements ; *Transcription, Genetic ; Transcriptional Activation

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Corepressor-dependent silencing of chromosomal regions encoding neuronal genes (2002)

V. V. Lunyak ; R. Burgess ; G. G. Prefontaine ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 298(5599): 1747-52. doi: 10.1126/science.1076469.

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Publication Date: 2002-10-26

Description: The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lunyak, Victoria V -- Burgess, Robert -- Prefontaine, Gratien G -- Nelson, Charles -- Sze, Sing-Hoi -- Chenoweth, Josh -- Schwartz, Phillip -- Pevzner, Pavel A -- Glass, Christopher -- Mandel, Gail -- Rosenfeld, Michael G -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1747-52. Epub 2002 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093-0648, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399542" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; Binding Sites ; Carrier Proteins ; Cell Line ; *Chromosomal Proteins, Non-Histone ; Chromosomes/*genetics/metabolism ; Chromosomes, Human/genetics/metabolism ; Co-Repressor Proteins ; Computational Biology ; CpG Islands ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; *Gene Silencing ; Histone Deacetylases/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Methyl-CpG-Binding Protein 2 ; Mice ; Models, Genetic ; NAV1.2 Voltage-Gated Sodium Channel ; Nerve Growth Factors/genetics ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Neurons/*metabolism ; Promoter Regions, Genetic ; Protein Structure, Tertiary ; Rats ; Repressor Proteins/chemistry/*metabolism ; Sodium Channels/genetics ; Transcription Factors/chemistry/*metabolism ; Transfection

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics