Publication Date:
2007-01-06
Description:
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dudziak, Diana -- Kamphorst, Alice O -- Heidkamp, Gordon F -- Buchholz, Veit R -- Trumpfheller, Christine -- Yamazaki, Sayuri -- Cheong, Cheolho -- Liu, Kang -- Lee, Han-Woong -- Park, Chae Gyu -- Steinman, Ralph M -- Nussenzweig, Michel C -- New York, N.Y. -- Science. 2007 Jan 5;315(5808):107-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17204652" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Antibodies, Monoclonal/immunology
;
*Antigen Presentation
;
Antigens, CD/analysis/immunology
;
Antigens, CD8/analysis/immunology
;
Base Sequence
;
Dendritic Cells/*immunology
;
Histocompatibility Antigens Class I/immunology
;
Histocompatibility Antigens Class II/immunology
;
Lectins, C-Type/analysis/immunology
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred C3H
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Molecular Sequence Data
;
Oligonucleotide Array Sequence Analysis
;
Receptors, Cell Surface/analysis/immunology
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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