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  • 1
    Electronic Resource
    Electronic Resource
    Ultra-Violet Sterilization of Water used for rearing Oyster Larvæ (1958)
    [s.l.] : Nature Publishing Group
    Nature 181 (1958), S. 1747-1747 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In order to avoid the necessity for washing the larvse, attempts were made to sterilize them and their surrounding water. Larvse exposed in a 1-cm. layer of water 25 cm. below the light source for periods of up to 8 min. were still active 18 hr. later. However, after exposures in excess of 40 sec. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1811747a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Floods on the Oyster Grounds of Eastern Britain (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 68-69 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALL the oyster-producing grounds of the east coast of Britain were within the area affected by the floods of January 1953, and in many cases the damage done was considerable. In Essex, where the major losses occurred, oyster cultivation is carried on in the estuaries of the Rivers Colne, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/173068b0
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  • 3
    Electronic Resource
    Electronic Resource
    Localized energy coupling during photophosphorylation by chromatophores ofRhodopseudomonas capsulata N22 (1982)
    Springer
    Bioscience reports 2 (1982), S. 743-749 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The principle of the dual inhibitor titration method for testing models of electron-transport phosphorylation is outlined, and the method is applied to the study of photophosphorylation in bacterial chromatophores. It is concluded that energy coupling is strictly localized in nature in this system, in the sense that free energy released by a particular electron-transport chain may be used only by a particular H+-ATP synthase. Dual inhibitor titrations using the uncoupler SF 6847 and the H+-ATP synthase inhibitor oligomycin indicate that uncouplers act by shuttling rapidly between the localized energy-coupling sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01114933
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  • 4
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    Deconstructing the galaxy stellar mass function with UKIDSS and CANDELS: the impact of colour, structure and environment (2014)
    Oxford University Press
    Details
    Publication Date: 2014-12-14
    Description: We combine photometry from the Ultra Deep Survey (UDS), Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) UDS and CANDELS the Great Observatories Origins Deep Survey-South (GOODS-S) surveys to construct the galaxy stellar mass function probing both the low- and high-mass end accurately in the redshift range 0.3 〈  z  〈 3. The advantages of using a homogeneous concatenation of these data sets include meaningful measures of environment in the UDS, due to its large area (0.88 deg 2 ), and the high-resolution deep imaging in CANDELS ( H 160  〉 26.0), affording us robust measures of structural parameters. We construct stellar mass functions for the entire sample as parametrized by the Schechter function, and find that there is a decline in the values of and of α with higher redshifts, and a nearly constant M * up to z  ~ 3. We divide the galaxy stellar mass function by colour, structure, and environment and explore the links between environmental overdensity, morphology, and the quenching of star formation. We find that a double Schechter function describes galaxies with high Sérsic index ( n  〉 2.5), similar to galaxies which are red or passive. The low-mass end of the n  〉 2.5 stellar mass function is dominated by blue galaxies, whereas the high-mass end is dominated by red galaxies. This shows that there is a possible link between morphological evolution and star formation quenching in high mass galaxies, which is not seen in lower mass systems. This in turn suggests that there are strong mass-dependent quenching mechanisms. In addition, we find that the number density of high-mass systems is elevated in dense environments, suggesting that an environmental process is building up massive galaxies quicker in over densities than in lower densities.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 5
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    The evolution of galaxies at constant number density: a less biased view of star formation, quenching, and structural formation (2016)
    Oxford University Press
    Details
    Publication Date: 2016-07-02
    Description: Due to significant galaxy contamination and impurity in stellar mass selected samples (up to 95 per cent from z  = 0–3), we examine the star formation history, quenching time-scales, and structural evolution of galaxies using a constant number density selection with data from the United Kingdom Infra-Red Deep Sky Survey Ultra-Deep Survey field. Using this methodology, we investigate the evolution of galaxies at a variety of number densities from z  = 0–3. We find that samples chosen at number densities ranging from 3  x  10 –4 to 10 –5 galaxies Mpc –3 (corresponding to z  ~ 0.5 stellar masses of M * = 10 10.95-11.6 M 0 ) have a star-forming blue fraction of ~50 per cent at z  ~ 2.5, which evolves to a nearly 100 per cent quenched red and dead population by z  ~ 1. We also see evidence for number density downsizing, such that the galaxies selected at the lowest densities (highest masses) become a homogeneous red population before those at higher number densities. Examining the evolution of the colours for these systems furthermore shows that the formation redshift of galaxies selected at these number densities is z form  〉 3. The structural evolution through size and Sérsic index fits reveal that while there remains evolution in terms of galaxies becoming larger and more concentrated in stellar mass at lower redshifts, the magnitude of the change is significantly smaller than for a mass-selected sample. We also find that changes in size and structure continues at z  〈 1, and is coupled strongly to passivity evolution. We conclude that galaxy structure is driving the quenching of galaxies, such that galaxies become concentrated before they become passive.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    Greenland ice dynamics from laser altimetry [Earth, Atmospheric, and Planetary Sciences] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-12-31
    Description: We present a new record of ice thickness change, reconstructed at nearly 100,000 sites on the Greenland Ice Sheet (GrIS) from laser altimetry measurements spanning the period 1993–2012, partitioned into changes due to surface mass balance (SMB) and ice dynamics. We estimate a mean annual GrIS mass loss of 243...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-17
    Description: Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is tumor necrosis factor-alpha (TNFalpha), which is shed from the plasma membrane after cleavage by the TNFalpha convertase (TACE). We report that the rhomboid family member iRhom2 interacted with TACE and regulated TNFalpha shedding. iRhom2 was critical for TACE maturation and trafficking to the cell surface in hematopoietic cells. Gene-targeted iRhom2-deficient mice showed reduced serum TNFalpha in response to lipopolysaccharide (LPS) and could survive a lethal LPS dose. Furthermore, iRhom2-deficient mice failed to control the replication of Listeria monocytogenes. Our study has identified iRhom2 as a regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250273/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250273/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McIlwain, David R -- Lang, Philipp A -- Maretzky, Thorsten -- Hamada, Koichi -- Ohishi, Kazuhito -- Maney, Sathish Kumar -- Berger, Thorsten -- Murthy, Aditya -- Duncan, Gordon -- Xu, Haifeng C -- Lang, Karl S -- Haussinger, Dieter -- Wakeham, Andrew -- Itie-Youten, Annick -- Khokha, Rama -- Ohashi, Pamela S -- Blobel, Carl P -- Mak, Tak W -- GM64750/GM/NIGMS NIH HHS/ -- R01 GM064750/GM/NIGMS NIH HHS/ -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Campell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network (UHN), 620 University Avenue, Toronto, Ontario M5G 2C1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22246778" target="_blank"〉PubMed〈/a〉
    Keywords: ADAM Proteins/genetics/*metabolism ; Amino Acid Sequence ; Animals ; B-Lymphocytes/immunology/metabolism ; Base Sequence ; Carrier Proteins/chemistry/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Gene Deletion ; *Immunity, Innate ; Lipopolysaccharides/*immunology ; Listeria monocytogenes/immunology/physiology ; Listeriosis/*immunology/metabolism/microbiology/pathology ; Macrophages/immunology/metabolism ; Macrophages, Peritoneal/immunology/metabolism/microbiology ; Mice ; Molecular Sequence Data ; Protein Transport ; Shock, Septic/*immunology/metabolism ; Spleen/cytology ; Tumor Necrosis Factor-alpha/blood/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Erratum: Deconstructing the Galaxy stellar mass function with UKIDSS and CANDELS: the impact of colour, structure and environment (2016)
    Oxford University Press
    Details
    Publication Date: 2016-04-04
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 9
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    Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-02-22
    Description: The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. Inactivating SDH and FH mutations cause the accumulation of succinate and fumarate, respectively, which can inhibit 2-oxoglutarate (2-OG)-dependent enzymes, including the EGLN prolyl 4-hydroxylases that mark the hypoxia inducible factor (HIF) transcription factor for polyubiquitylation and proteasomal degradation. Inappropriate HIF activation is suspected of contributing to the pathogenesis of SDH-defective and FH-defective tumours but can suppress tumour growth in some other contexts. IDH1 and IDH2, which catalyse the interconversion of isocitrate and 2-OG, are frequently mutated in human brain tumours and leukaemias. The resulting mutants have the neomorphic ability to convert 2-OG to the (R)-enantiomer of 2-hydroxyglutarate ((R)-2HG). Here we show that (R)-2HG, but not (S)-2HG, stimulates EGLN activity, leading to diminished HIF levels, which enhances the proliferation and soft agar growth of human astrocytes. These findings define an enantiomer-specific mechanism by which the (R)-2HG that accumulates in IDH mutant brain tumours promotes transformation and provide a justification for exploring EGLN inhibition as a potential treatment strategy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656605/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656605/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koivunen, Peppi -- Lee, Sungwoo -- Duncan, Christopher G -- Lopez, Giselle -- Lu, Gang -- Ramkissoon, Shakti -- Losman, Julie A -- Joensuu, Paivi -- Bergmann, Ulrich -- Gross, Stefan -- Travins, Jeremy -- Weiss, Samuel -- Looper, Ryan -- Ligon, Keith L -- Verhaak, Roel G W -- Yan, Hai -- Kaelin, William G Jr -- R01 CA068490/CA/NCI NIH HHS/ -- R01 CA140316/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Feb 15;483(7390):484-8. doi: 10.1038/nature10898.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22343896" target="_blank"〉PubMed〈/a〉
    Keywords: Astrocytes/cytology/drug effects/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Transformation, Neoplastic/*drug effects/genetics/*metabolism ; Dioxygenases/genetics/*metabolism ; Enzyme Activation/drug effects ; Glioma/enzymology/genetics/metabolism/pathology ; Glutarates/*chemistry/metabolism/*pharmacology ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Isocitrate Dehydrogenase/genetics/metabolism ; Nuclear Proteins/genetics/*metabolism ; Oncogenes ; Procollagen-Proline Dioxygenase/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Engineering. Privacy by design (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-09-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duncan, George -- New York, N.Y. -- Science. 2007 Aug 31;317(5842):1178-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉H. John Heinz III School of Public Policy and Management, Carnegie Mellon University, Pittsburgh, PA 15213, USA. gd17@andrew.cmu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17761870" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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