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  • 1
    Publication Date: 2015-12-08
    Description: Author(s): H. Fukaya, S. Aoki, G. Cossu, S. Hashimoto, T. Kaneko, and J. Noaki (JLQCD Collaboration) The flavor-singlet component of the η ′ meson is related to the topological structure of the SU(3) gauge field through the chiral anomaly. We perform a 2 + 1 -flavor lattice QCD calculation and demonstrate that the two-point function of a gluonically defined topological charge density after a short Yang… [Phys. Rev. D 92, 111501(R)] Published Mon Dec 07, 2015
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 2
    Publication Date: 1999-01-15
    Description: The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ledent, C -- Valverde, O -- Cossu, G -- Petitet, F -- Aubert, J F -- Beslot, F -- Bohme, G A -- Imperato, A -- Pedrazzini, T -- Roques, B P -- Vassart, G -- Fratta, W -- Parmentier, M -- New York, N.Y. -- Science. 1999 Jan 15;283(5400):401-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIBHN, Universite libre de Bruxelles, B-1070 Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9888857" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics, Opioid/pharmacology ; Animals ; Behavior, Animal/drug effects ; Blood Pressure/drug effects ; Body Temperature/drug effects ; Cannabinoids/metabolism/*pharmacology ; Dronabinol/*pharmacology ; Heart Rate/drug effects ; Mice ; Mice, Knockout ; Morphine/pharmacology ; Motor Activity/drug effects ; Narcotics/*pharmacology ; Opioid-Related Disorders/*physiopathology ; Pain Threshold/drug effects ; Receptors, Cannabinoid ; Receptors, Drug/genetics/*physiology ; Receptors, Opioid, kappa/agonists/physiology ; Reinforcement (Psychology) ; Substance Withdrawal Syndrome/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2001-03-17
    Description: The recognition of dyslexia as a neurodevelopmental disorder has been hampered by the belief that it is not a specific diagnostic entity because it has variable and culture-specific manifestations. In line with this belief, we found that Italian dyslexics, using a shallow orthography which facilitates reading, performed better on reading tasks than did English and French dyslexics. However, all dyslexics were equally impaired relative to their controls on reading and phonological tasks. Positron emission tomography scans during explicit and implicit reading showed the same reduced activity in a region of the left hemisphere in dyslexics from all three countries, with the maximum peak in the middle temporal gyrus and additional peaks in the inferior and superior temporal gyri and middle occipital gyrus. We conclude that there is a universal neurocognitive basis for dyslexia and that differences in reading performance among dyslexics of different countries are due to different orthographies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paulesu, E -- Demonet, J F -- Fazio, F -- McCrory, E -- Chanoine, V -- Brunswick, N -- Cappa, S F -- Cossu, G -- Habib, M -- Frith, C D -- Frith, U -- New York, N.Y. -- Science. 2001 Mar 16;291(5511):2165-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Psychology Department, University of Milan Bicocca, Milan, Italy. eraldo.paulesu@unimib.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11251124" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/blood supply/*physiopathology/radionuclide imaging ; Cross-Cultural Comparison ; *Culture ; Dyslexia/*etiology/physiopathology ; France ; Great Britain ; Humans ; Italy ; *Language ; Male ; Matched-Pair Analysis ; Occipital Lobe/blood supply/physiopathology/radionuclide imaging ; Reading ; Regional Blood Flow ; Temporal Lobe/blood supply/*physiopathology/radionuclide imaging ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1998-03-21
    Description: Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferrari, G -- Cusella-De Angelis, G -- Coletta, M -- Paolucci, E -- Stornaiuolo, A -- Cossu, G -- Mavilio, F -- A.067/Telethon/Italy -- TGT06S01/Telethon/Italy -- New York, N.Y. -- Science. 1998 Mar 6;279(5356):1528-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉H. San Raffaele-Telethon Institute for Gene Therapy (TIGET), 20132 Milan, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9488650" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells/cytology/*physiology ; Bone Marrow Transplantation ; Cell Differentiation ; Cell Movement ; Genetic Therapy ; Humans ; Mice ; Mice, SCID ; Mice, Transgenic ; Muscle Fibers, Skeletal/cytology ; Muscle, Skeletal/*cytology/*physiology ; Muscular Dystrophies/therapy ; *Regeneration ; Stem Cells/*physiology ; Stromal Cells/cytology/physiology ; beta-Galactosidase/analysis/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2003-07-12
    Description: Preclinical or clinical trials for muscular dystrophies have met with modest success, mainly because of inefficient delivery of viral vectors or donor cells to dystrophic muscles. We report here that intra-arterial delivery of wild-type mesoangioblasts, a class of vessel-associated stem cells, corrects morphologically and functionally the dystrophic phenotype of virtually all downstream muscles in adult immunocompetent alpha-sarcoglycan (alpha-SG) null mice, a model organism for limb-girdle muscular dystrophy. When mesoangioblasts isolated from juvenile dystrophic mice and transduced with a lentiviral vector expressing alpha-SG were injected into the femoral artery of dystrophic mice, they reconstituted skeletal muscle in a manner similar to that seen in wild-type cells. The success of this protocol was mainly due to widespread distribution of donor stem cells through the capillary network, a distinct advantage of this strategy over previous approaches.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sampaolesi, Maurilio -- Torrente, Yvan -- Innocenzi, Anna -- Tonlorenzi, Rossana -- D'Antona, Giuseppe -- Pellegrino, M Antonietta -- Barresi, Rita -- Bresolin, Nereo -- De Angelis, M Gabriella Cusella -- Campbell, Kevin P -- Bottinelli, Roberto -- Cossu, Giulio -- 1322/Telethon/Italy -- 463/BI/Telethon/Italy -- New York, N.Y. -- Science. 2003 Jul 25;301(5632):487-92. Epub 2003 Jul 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stem Cell Research Institute, H. S. Raffaele, Via Olgettina 58, 20132 Milan, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12855815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Vessels/cytology/embryology ; Cell Differentiation ; Cell Line ; Cell Movement ; Cytoskeletal Proteins/*genetics/*metabolism ; Dystrophin/metabolism ; Endothelium, Vascular/physiology ; Female ; Femoral Artery ; Genetic Vectors ; Lentivirus/genetics ; Locomotion ; Male ; Membrane Glycoproteins/*genetics/*metabolism ; Mesoderm/cytology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Muscle Contraction ; Muscle Fibers, Skeletal/cytology/physiology ; Muscle, Skeletal/cytology/metabolism/pathology/*physiology ; Muscular Dystrophy, Animal/metabolism/pathology/*therapy ; Regeneration ; Sarcoglycans ; *Stem Cell Transplantation ; Stem Cells/*physiology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2016-02-17
    Description: Author(s): S. Aoki, G. Cossu, X. Feng, S. Hashimoto, T. Kaneko, J. Noaki, and T. Onogi We study the chiral behavior of the electromagnetic (EM) form factors of pions and kaons in three-flavor lattice QCD. In order to make a direct comparison of the lattice data with chiral perturbation theory (ChPT), we employ the overlap quark action that has exact chiral symmetry. Gauge ensembles ar… [Phys. Rev. D 93, 034504] Published Tue Feb 16, 2016
    Keywords: Lattice Methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 7
    Publication Date: 2013-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sampaolesi, Maurilio -- Blot, Stephane -- D'Antona, Giuseppe -- Granger, Nicolas -- Tonlorenzi, Rossana -- Innocenzi, Anna -- Mognol, Paolo -- Thibaud, Jean-Lauren -- Galvez, Beatriz G -- Barthelemy, Ines -- Perani, Laura -- Mantero, Sara -- Guttinger, Maria -- Pansarasa, Orietta -- Rinaldi, Chiara -- De Angelis, M Gabriella Cusella -- Torrente, Yvan -- Bordignon, Claudio -- Bottinelli, Roberto -- Cossu, Giulio -- Nature. 2013 Feb 20;494(7438):506. doi: 10.1038/nature11976. Epub 2013 Feb 20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23426261" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2017-09-16
    Description: Author(s): M. Tomii, G. Cossu, B. Fahy, H. Fukaya, S. Hashimoto, T. Kaneko, and J. Noaki (JLQCD Collaboration) We study the vector and axial-vector current correlators in perturbative and nonperturbative regimes of QCD. The correlators in Euclidean coordinate space are calculated on the lattice using the Möbius domain-wall fermion formulation at three lattice spacings covering 0.044–0.080 fm. The dynamical q... [Phys. Rev. D 96, 054511] Published Fri Sep 15, 2017
    Keywords: Lattice field theories, lattice QCD
    Print ISSN: 0556-2821
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  • 9
    Publication Date: 2017-08-12
    Description: Author(s): A. Tomiya, G. Cossu, S. Aoki, H. Fukaya, S. Hashimoto, T. Kaneko, and J. Noaki (JLQCD Collaboration) We study the axial U ( 1 ) symmetry at a finite temperature in two-flavor lattice QCD. Employing the Möbius domain-wall fermions, we generate gauge configurations slightly above the critical temperature T c with different lattice sizes L = 2 – 4     fm . Our action allows frequent topology tunneling while keepi... [Phys. Rev. D 96, 034509] Published Thu Aug 10, 2017
    Keywords: Lattice field theories, lattice QCD
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  • 10
    Publication Date: 2017-08-04
    Description: Author(s): S. Aoki, G. Cossu, X. Feng, H. Fukaya, S. Hashimoto, T. Kaneko, J. Noaki, and T. Onogi (JLQCD Collaboration) We calculate the form factors of the K → π l ν semileptonic decays in three-flavor lattice QCD and study their chiral behavior as a function of the momentum transfer and the Nambu-Goldstone boson masses. Chiral symmetry is exactly preserved by using the overlap quark action, which enables us to directly... [Phys. Rev. D 96, 034501] Published Thu Aug 03, 2017
    Keywords: Lattice field theories, lattice QCD
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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