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  • 1
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    Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-02-12
    Description: The Gram-negative bacterium Neisseria meningitidis asymptomatically colonizes the throat of 10 to 30% of the human population, but throat colonization can also act as the port of entry to the blood (septicemia) and then the brain (meningitis). Colonization is mediated by filamentous organelles referred to as type IV pili, which allow the formation of bacterial aggregates associated with host cells. We found that proliferation of N. meningitidis in contact with host cells increased the transcription of a bacterial gene encoding a transferase that adds phosphoglycerol onto type IV pili. This unusual posttranslational modification specifically released type IV pili-dependent contacts between bacteria. In turn, this regulated detachment process allowed propagation of the bacterium to new colonization sites and also migration across the epithelium, a prerequisite for dissemination and invasive disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamot-Rooke, Julia -- Mikaty, Guillain -- Malosse, Christian -- Soyer, Magali -- Dumont, Audrey -- Gault, Joseph -- Imhaus, Anne-Flore -- Martin, Patricia -- Trellet, Mikael -- Clary, Guilhem -- Chafey, Philippe -- Camoin, Luc -- Nilges, Michael -- Nassif, Xavier -- Dumenil, Guillaume -- New York, N.Y. -- Science. 2011 Feb 11;331(6018):778-82. doi: 10.1126/science.1200729.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ecole Polytechnique, Laboratoire des Mecanismes Reactionnels, Palaiseau F-91128, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21311024" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Adhesion ; Cell Line, Tumor ; Epithelial Cells/microbiology ; Fimbriae Proteins/chemistry/*metabolism ; Fimbriae, Bacterial/chemistry/*metabolism ; Gene Expression Regulation, Bacterial ; Glycerol/metabolism ; Humans ; Models, Molecular ; Neisseria meningitidis/genetics/growth & development/*pathogenicity ; Phosphorylation ; Phosphotransferases/*genetics/*metabolism ; *Protein Processing, Post-Translational ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Bending and buckling of carbon nanotubes under large strain (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 582-584 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The curling of a graphitic sheet to form carbon nanotubes produces a class of materials that seem to have extraordinary electrical and mechanical properties. In particular, the high elastic modulus of the graphite sheets means that the nanotubes might be stiffer and stronger than any other ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/39282
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Bending and buckling of carbon nanotubes under large strain (1997)
    Springer Nature
    Details
    Publication Date: 1997-10-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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    PAPER CURRENT
  • 4
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    Development and flight test of a helicopter, X-band, portable precision landing system concept (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: A beacon landing system (BLS) is being developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. The system is based on state-of-the-art X-band radar technology and digital processing techniques. The BLS airborne hardware consists of an X-band receiver and a small microprocessor, installed in conjunction with the aircraft instrument landing system (ILS) receiver. The microprocessor analyzes the X-band, BLS pulses and outputs ILS-compatible localizer and glide slope signals. Range information is obtained using an on-board weather/mapping radar in conjunction with the BLS. The ground station is an inexpensive, portable unit; it weighs less than 70 lb and can be quickly deployed at a landing site. Results from the flight-test program show that the BLS has a significant potential for providing rotorcraft with low-cost, precision instrument approach capability in remote areas.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    Development and flight test of a weather radar precision approach concept (1984)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: In order to make full use of the helicopter's unique capability of remote-site, off-airport landings, it would be desirable to employ a self-contained navigation system requiring minimum groundable-based equipment. For this reason, research is being conducted with the aim to develop the use of airborne weather radar as a primary navigation aid for helicopter approach and landing in instrument flight rules (IFR) conditions. Anderson et al. (1982) have reported about the first phase of this effort, taking into account the detection of passive ground-based corner reflectors with the aid of an 'echo processor'. The technology of passive-reflector detection in the overland environment provides the pilot with the range and bearing to the landing site. The present investigation is concerned with a second research phase, which was undertaken with the objective to develop and demonstrate the feasibility of a weather radar-based precision approach concept. Preliminary flight test results are considered.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    Development and flight test of an X-band precision approach concept for remote-area rotorcraft operations (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: A novel airborne radar-based precision approach concept was developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. A demonstration, transponder-based beacon landing system (BLS), incorporating state-of-the-art X-band radar technology and digital processing techniques, was built and flight tested to demonstrate the concept feasibility. The BLS airborne hardware consists of an add-on microprocessor, installed in conjunction with the aircraft weather/mapping radar, which analyzes the radar beacon receiver returns and determines range, localizer deviation, and glide slope deviation. The ground station is an inexpensive, portable unit which can be quickly deployed at a landing site. Results from the flight test program show that the BLS concept has a significant potential for providing rotorcraft with low-cost, precision, instrument approach capability in remote areas. Previously announced in STAR as N84-10041
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    Development and flight test of a helicopter compact, portable, precision landing system concept (1984)
    In:  CASI
    Details
    Publication Date: 2017-10-02
    Description: An airborne, radar based, precision approach concept is being developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. A transponder based beacon landing system (BLS) applying state of the art X band radar technology and digital processing techniques, has been built and is being flight tested to demonstrate the concept feasibility. The BLS airborne hardware consists of an add on microprocessor, installed in conjunction with the aircraft weather/mapping radar, which analyzes the radar beacon receiver returns and determines range, localizer deviation, and glide slope derivation. The ground station is an inexpensive, portable unit which can be quickly deployed at a landing site. Results from the flight test program show that the BLS concept has a significant potential for providing rotorcraft with low cost, precision instrument approach capability in remote areas.
    Keywords: AIRCRAFT INSTRUMENTATION
    Type: AGARD Helicopter Guidance and Control Systems for Battlefield Support; 8 p
    Format: text
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    NASA TECHNICAL REPORTS
  • 8
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    Development of a portable precision landing system (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A portable, tactical approach guidance (PTAG) system, based on a novel, X-band, precision approach concept, was developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. The system is based on state-of-the-art X-band technology and digital processing techniques. The PTAG airborne hardware consists of an X-band receiver and a small microprocessor installed in conjunction with the aircraft instrument landing system (ILS) receiver. The microprocessor analyzes the X-band, PTAG pulses and outputs ILS compatible localizer and glide slope signals. The ground stations are inexpensive, portable units, each weighing less than 85 lb, including battery, that can be quickly deployed at a landing site. Results from the flight test program show that PTAG has a significant potential for providing tactical aircraft with low cost, portable, precision instrument approach capability.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Type: NASA-TM-88247 , A-86227 , NAS 1.15:88247
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 9
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    Development and flight test of a helicopter compact, portable, precision landing system concept (1984)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: An airborne, radar-based, precision approach concept is being developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. A transponder-based beacon landing system (BLS) applying state-of-the-art X-band radar technology and digital processing techniques, was built and is being flight tested to demonstrate the concept feasibility. The BLS airborne hardware consists of an add-on microprocessor, installed in conjunction with the aircraft weather/mapping radar, which analyzes the radar beacon receiver returns and determines range, localizer deviation, and glide-slope deviation. The ground station is an inexpensive, portable unit which can be quickly deployed at a landing site. Results from the flight test program show that the BLS concept has a significant potential for providing rotorcraft with low-cost, precision instrument approach capability in remote areas.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Type: NASA-TM-85951 , A-9729 , NAS 1.15:85951
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 10
    facet.materialart.
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    Development and flight test of a helicopter, X-band, portable precision landing system concept (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: A beacon landing system (BLS) is being developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. The system is based on state-of-of-the-art X-band radar technology and digital processing techniques. The bLS airborne hardware consists of an X-band receiver and a small micropreocessor, installed in conjunction wht the aircraft instrument landing system (ILS) receiver. The microprocessor analyzes the X-band, BLS pulses and outputs ILS-compatible localizer and glide slope signals. Range information is obtained using an on-board weather/mapping radar in conjunction with the BLS. The ground station is an inexpensive, portable unit; it weighs less than 70 lb and can be quickly deployed at a landing site. Results from the flight-test program show that the BLS has a significant potential for providing rotorcaraft with low-cost, precision instrument approach capability in remote areas.
    Keywords: AIRCRAFT STABILITY AND CONTROL
    Type: NASA-TM-86710 , NAS 1.15:86710
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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