Publication Date:
2017-11-27
Description:
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients, Published online: 27 November 2017; doi:10.1038/s41467-017-01700-3 Autoantibodies are found in neuropsychiatric conditions but without clear cellular mechanism and disease relevance. This study shows higher prevalence of autoantibodies against NMDAR receptors in schizophrenia patients, and patient-associated antibody can alter synaptic receptor trafficking and plasticity.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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