ISSN:
0951-4198
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Physics
Notes:
The separation of trace impurities in cimetidine drug substance by high pressure liquid chromatography (HPLC) showed a series of minor components. These were analysed using an on-line electrospray source connected to a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Working typically with a resolution of 10 000-20 000 accurate mass measurement of the components confirmed their empirical formulae to generally better than 5 ppm accuracy. This work shows that the combination of conventional analytical HPLC using 4.6 mm columns with a low flow rate electrospray source interfaced to an FT-ICR mass spectrometer enables structural information to be obtained on low levels of low mass components.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/rcm.1290091111
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