ISSN:
1476-5535
Keywords:
cyclosporins
;
cyclosporin-like peptolides
;
fungal taxa
;
Acremonium luzulae
;
Leptostroma anamorph ofHypoderma eucalyptii
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract Apart from 17 previously listed fungal taxa producing cyclosporin A and its natural congeners B to Z, several additional and taxonomically diverse strains producing the single novel component [Thr2, Leu5, Leu10]cyclosporin or cyclosporin-like peptolides (eg SDZ 214-103=[Thr2, Leu5, D-Hiv8, Leu10]cyclosporin) have recently been described. We report here the isolation of two further and novel cyclosporins, [Thr2, Leu5, Ala10]cyclosporin (2) and [Thr2, Ile5] cyclosporin (3), from strains classified asAcremonium luzulae (Fuckel) W Gams andLeptostroma anamorph ofHypoderma eucalyptii Cooke & Harkn, respectively. In both new strains the usual pattern of cyclosporins A to Z is not found. The structure elucidations of2 and3 are based on NMR spectroscopy, and biological data (immunosuppressive activity, cyclophilin-binding affinity and antifungal effects) are presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01574770
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