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  • 1
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    Structure of PTB bound to RNA: specific binding and implications for splicing regulation (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-09-24
    Description: The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oberstrass, Florian C -- Auweter, Sigrid D -- Erat, Michele -- Hargous, Yann -- Henning, Anke -- Wenter, Philipp -- Reymond, Luc -- Amir-Ahmady, Batoul -- Pitsch, Stefan -- Black, Douglas L -- Allain, Frederic H-T -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2054-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Molecular Biology and Biophysics, Department of Biology, Swiss Federal Institute of Technology, Zurich, ETH-Honggerberg, CH-8093 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179478" target="_blank"〉PubMed〈/a〉
    Keywords: *Alternative Splicing ; Amino Acid Sequence ; Base Sequence ; Binding Sites ; Exons ; Heterogeneous-Nuclear Ribonucleoproteins/*chemistry/genetics/*metabolism ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Nuclear Proteins/metabolism ; Oligoribonucleotides ; Polypyrimidine Tract-Binding Protein/*chemistry/genetics/*metabolism ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; RNA/*chemistry/*metabolism ; Ribonucleoproteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-20
    Description: A component present in splicing extracts selectively binds the 3' splice site of a precursor messenger RNA (pre-mRNA) transcript of a human beta-globin gene. Since this component can be immunoprecipitated by either autoantibodies of the Sm class or antibodies specifically directed against trimethylguanosine, it is a small nuclear ribonucleoprotein (snRNP). Its interaction with the 3' splice site occurs rapidly even at 0 degrees C, does not require adenosine triphosphate, and is altered by certain mutations in the 3' splice site region. Binding is surprisingly insensitive to treatment of the extract with micrococcal nuclease. The U5 particle is the only abundant Sm snRNP with a capped 5' end that is equally resistant to micrococcal nuclease. This suggests that, in addition to the U1 and U2 snRNP's, U5 snRNP's participate in pre-mRNA splicing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chabot, B -- Black, D L -- LeMaster, D M -- Steitz, J A -- GM-26154/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1344-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2933810" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Binding Sites ; Globins/genetics ; Humans ; Nucleic Acid Conformation ; Nucleic Acid Precursors/*genetics/metabolism ; Protein Binding ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/*genetics/metabolism ; Ribonucleoproteins/*genetics/metabolism ; Ribonucleoproteins, Small Nuclear ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    The Effect of Stretch-Tension During Rigor on Certain Physical Characteristics of Bovine Muscle (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 32 (1967), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: SUMMARY— Seven pairs of muscle strips prepared from bovine longissimus dorsi muscles were subjected to two degrees of stretch-tension during rigor. Individual muscle fiber extensibility was determined and found to be significantly less in stretched muscle strips (P 〈 0.001). The average muscle fiber diameter was also significantly smaller in stretched muscle strips (P 〈 0.001). Tenderness of samples was determined objectively with an Allo-Kramer Shear Press. Significantly less force was required to shear samples from the stretched muscle strips in five of seven trials (P 〈 0.01). The inconsistent results obtained in two of the tenderness trials are explained on the basis of uneven heat penetration during cooking due to changes in volume resulting from stretch treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1967.tb00827.x
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  • 4
    Electronic Resource
    Electronic Resource
    Microscopic Characteristics of Cooked Muscles Subjected to Stretch-Tension during Rigor (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 33 (1968), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: SUMMARY– Frozen sections, representing the entire cross-sectional area at the site of shear force determination, were prepared from cooked muscle samples previously subjected to two degrees of stretch-tension during rigor. Histological observations revealed very few consistent relationships between structure at the shearing site and shear force values. Sections prepared from control samples exhibited significantly greater total amounts of perimysial connective tissue than sections prepared from stretched samples. Stretched sections tended to show greater amounts of perimysial tissue denaturation as indicated by the degree of tissue granulation. These results suggest that a portion of the increased tenderness previously reported for stretched muscle samples may be accounted for by a mechanical thinning of connective tissues due to stretching which results in a decrease in force required for shearing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1968.tb03656.x
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  • 5
    Electronic Resource
    Electronic Resource
    Allografts and Xenografts of Oviduct to the Cheek Pouch of the Syrian Hamster (1967)
    [s.l.] : Nature Publishing Group
    Nature 213 (1967), S. 710-711 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Oviducts were dissected from hamsters anaesthetized with 'Nembutal' after ligature of the utero-tubal junction and the ovarian end of the oviduct. Entire oviducts were dissected from rabbits killed by cervical dislocation or from dairy cows at the university abattoir. In each instance, the tissues ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/213710a0
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  • 6
    Electronic Resource
    Electronic Resource
    Microdochium bolleyi associated with root rot of flax (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 35 (1986), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1986.tb02060.x
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  • 7
    Electronic Resource
    Electronic Resource
    The crystal and molecular structures of the trimethylphosphine–boron trihalide complexes: (CH3)3PBCl3, (CH3)3PBBr3 and (CH3)3PBI3 (1975)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 31 (1975), S. 1116-1120 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740875004621
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  • 8
    Electronic Resource
    Electronic Resource
    Homotransplantation of the Hamster Uterus (1965)
    [s.l.] : Nature Publishing Group
    Nature 205 (1965), S. 720-720 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Twenty adult female hamsters (Mesocricetus auratus) weighing between 60 and 100 g were used as donor animals. Sub-total hysterectomies were performed on the donor animals anaesthetized with sterile 'Nembuta? (7 mg/100 g of body-weight). Each hysterectomized animal then became a host. The uterus was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/205720a0
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of Multiple Anterior Pituitary Allografts on the Oestrous Cycle of the Syrian Hamster (1967)
    [s.l.] : Nature Publishing Group
    Nature 213 (1967), S. 195-196 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The cheek pouch is used as the site of transplantation because of the simplicity of the technique and the peculiar properties of the pouch, which make it suitable5. Donors (adult male or female hamsters, Mesocricetus auratus] were decapitated under light ether anaesthesia. The anterior pituitary ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/213195a0
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  • 10
    Electronic Resource
    Electronic Resource
    Transplantation of Rabbit Oviduct to the Cheek Pouch of the Syrian Hamster (1964)
    [s.l.] : Nature Publishing Group
    Nature 202 (1964), S. 810-810 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Documentation of successful homo- and hetero-transplantations to the hamster cheek pouch may be found in Billingham et al.1, Cohen2, and Resnick et al.3. The structure of the cheek pouch has been described by Billingham and Silvers4. They state that the wall of the pouch consists of (1) stratified ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/202810a0
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