Publication Date:
1996-09-27
Description:
The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4(+) T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell receptor specific for myelin basic protein. These mice failed to develop EAE after priming with antigen, and CD4(+) T cells remained quiescent and produced no interferon-gamma (IFN-gamma). T cells were primed to make IFN-gamma and induce EAE by providing these mice with B7.1(+) antigen-presenting cells (APCs). Thus, CD40L is required to induce costimulatory activity on APCs for in vivo activation of CD4(+) T cells to produce IFN-gamma and to evoke autoimmunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grewal, I S -- Foellmer, H G -- Grewal, K D -- Xu, J -- Hardardottir, F -- Baron, J L -- Janeway, C A Jr -- Flavell, R A -- New York, N.Y. -- Science. 1996 Sep 27;273(5283):1864-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8791592" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/*immunology
;
Antigens, CD/biosynthesis
;
Antigens, CD80/biosynthesis/immunology
;
Antigens, CD86
;
Brain/immunology/pathology
;
CD4-Positive T-Lymphocytes/*immunology
;
CD40 Ligand
;
Encephalomyelitis, Autoimmune, Experimental/*immunology/pathology
;
Interferon-gamma/biosynthesis
;
Interleukin-4/biosynthesis
;
*Lymphocyte Activation
;
Membrane Glycoproteins/biosynthesis/*immunology
;
Mice
;
Mice, Transgenic
;
Myelin Basic Protein/immunology
;
Receptors, Antigen, T-Cell/immunology
;
Spinal Cord/immunology/pathology
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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