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  • 1
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    Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-10-13
    Description: Autologous peripheral nerve grafts were used to permit and direct the regrowth of retinal ganglion cell axons from the eye to the ipsilateral superior colliculus of adult hamsters in which the optic nerves had been transected within the orbit. Extracellular recordings in the superior colliculus 15 to 18 weeks after graft insertion revealed excitatory and inhibitory postsynaptic responses to visual stimulation. The finding of light-induced responses in neurons in the superficial layers of the superior colliculus close to the graft indicates that axons regenerating from axotomized retinal ganglion cells can establish electrophysiologically functional synapses with neurons in the superior colliculus of these adult mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keirstead, S A -- Rasminsky, M -- Fukuda, Y -- Carter, D A -- Aguayo, A J -- Vidal-Sanz, M -- New York, N.Y. -- Science. 1989 Oct 13;246(4927):255-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurosciences Unit, Montreal General Hospital, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2799387" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Axons/physiology ; Cricetinae ; Mesocricetus ; Nerve Regeneration/*physiology ; Optic Nerve/*physiology ; Photic Stimulation ; Retinal Ganglion Cells/physiology ; Superior Colliculi/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A photosynthetic alveolate closely related to apicomplexan parasites (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-02-22
    Description: Many parasitic Apicomplexa, such as Plasmodium falciparum, contain an unpigmented chloroplast remnant termed the apicoplast, which is a target for malaria treatment. However, no close relative of apicomplexans with a functional photosynthetic plastid has yet been described. Here we describe a newly cultured organism that has ultrastructural features typical for alveolates, is phylogenetically related to apicomplexans, and contains a photosynthetic plastid. The plastid is surrounded by four membranes, is pigmented by chlorophyll a, and uses the codon UGA to encode tryptophan in the psbA gene. This genetic feature has been found only in coccidian apicoplasts and various mitochondria. The UGA-Trp codon and phylogenies of plastid and nuclear ribosomal RNA genes indicate that the organism is the closest known photosynthetic relative to apicomplexan parasites and that its plastid shares an origin with the apicoplasts. The discovery of this organism provides a powerful model with which to study the evolution of parasitism in Apicomplexa.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, Robert B -- Obornik, Miroslav -- Janouskovec, Jan -- Chrudimsky, Tomas -- Vancova, Marie -- Green, David H -- Wright, Simon W -- Davies, Noel W -- Bolch, Christopher J S -- Heimann, Kirsten -- Slapeta, Jan -- Hoegh-Guldberg, Ove -- Logsdon, John M -- Carter, Dee A -- England -- Nature. 2008 Feb 21;451(7181):959-63. doi: 10.1038/nature06635.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Molecular and Microbial Biosciences, University of Sydney, Darlington, New South Wales 2006, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18288187" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/genetics ; Chlorophyll/metabolism ; Codon/genetics ; Eukaryotic Cells/*classification/cytology/*metabolism/ultrastructure ; Parasites/*classification/*cytology/genetics/ultrastructure ; *Photosynthesis ; *Phylogeny ; Plasmodium falciparum/classification ; Plastids/genetics/*metabolism ; RNA, Ribosomal/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Long-Term Mean Vertical Motion over the Tropical Pacific: Wind-Profiling Doppler Radar Measurements (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-20
    Description: Measurement from Christmas Island (2 degrees N, 157 degrees W) of long-term mean vertical motions in the tropical atmosphere using very-high-frequency wind-profiling Doppler radar show that there is a transition from downward motion in the free troposphere to upward motion in the upper troposphere and lower stratosphere. The observations in the free troposphere are consistent with a balance between adiabatic and diabatic heating and cooling rates in a clear atmosphere. Comparison of the results at Christmas Island during El Nino and non-El Nino conditions with earlier results obtained for stratiform rain conditions over Pohnpei, Federated States of Micronesia, show that cirrus clouds in the vicinity of the tropopause likely play an important role in determining the sense and magnitude of vertical motions in this region. These results have implications for the exchange of mass between the troposphere and stratosphere over the tropics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gage, K S -- McAfee, J R -- Carter, D A -- Ecklund, W L -- Riddle, A C -- Reid, G C -- Balsley, B B -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17829241" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Piezo1 integration of vascular architecture with physiological force (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-08-15
    Description: The mechanisms by which physical forces regulate endothelial cells to determine the complexities of vascular structure and function are enigmatic. Studies of sensory neurons have suggested Piezo proteins as subunits of Ca(2+)-permeable non-selective cationic channels for detection of noxious mechanical impact. Here we show Piezo1 (Fam38a) channels as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology. Global or endothelial-specific disruption of mouse Piezo1 profoundly disturbed the developing vasculature and was embryonic lethal within days of the heart beating. Haploinsufficiency was not lethal but endothelial abnormality was detected in mature vessels. The importance of Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells. Downstream of this calcium influx there was protease activation and spatial reorganization of endothelial cells to the polarity of the applied force. The data suggest that Piezo1 channels function as pivotal integrators in vascular biology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230887/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230887/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Jing -- Hou, Bing -- Tumova, Sarka -- Muraki, Katsuhiko -- Bruns, Alexander -- Ludlow, Melanie J -- Sedo, Alicia -- Hyman, Adam J -- McKeown, Lynn -- Young, Richard S -- Yuldasheva, Nadira Y -- Majeed, Yasser -- Wilson, Lesley A -- Rode, Baptiste -- Bailey, Marc A -- Kim, Hyejeong R -- Fu, Zhaojun -- Carter, Deborah A L -- Bilton, Jan -- Imrie, Helen -- Ajuh, Paul -- Dear, T Neil -- Cubbon, Richard M -- Kearney, Mark T -- Prasad, K Raj -- Evans, Paul C -- Ainscough, Justin F X -- Beech, David J -- 083857/Wellcome Trust/United Kingdom -- FS/12/54/29671/British Heart Foundation/United Kingdom -- FS/12/80/29821/British Heart Foundation/United Kingdom -- FS/14/22/30734/British Heart Foundation/United Kingdom -- G0901761(93442)/Medical Research Council/United Kingdom -- G1002076/Medical Research Council/United Kingdom -- RG/13/1/30042/British Heart Foundation/United Kingdom -- Biotechnology and Biological Sciences Research Council/United Kingdom -- British Heart Foundation/United Kingdom -- Cancer Research UK/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2014 Nov 13;515(7526):279-82. doi: 10.1038/nature13701. Epub 2014 Aug 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] School of Medicine and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, UK [2]. ; School of Medicine and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, UK. ; School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya 464-8650, Japan. ; 1] School of Medicine and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, UK [2] Department of Hepatobiliary and Transplant Surgery, St. James's University Hospital, Leeds, LS9 7TF, UK. ; Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK. ; Dundee Cell Products Ltd, James Lindsay Place, Dundee DD1 5JJ, UK. ; Department of Hepatobiliary and Transplant Surgery, St. James's University Hospital, Leeds, LS9 7TF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25119035" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryo, Mammalian/blood supply/metabolism ; Endothelial Cells/*cytology/*physiology ; Female ; *Friction ; Hemorheology ; Ion Channels/*metabolism ; Male ; Mice ; *Stress, Mechanical
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
    Electronic Resource
    Electronic Resource
    Spectrofluorometric Study of (2-Methyl-8-quinolinolato)Zinc(II) Chelates in Absolute Ethyl Alcohol. (1964)
    s.l. : American Chemical Society
    Analytical chemistry 36 (1964), S. 327-330 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60208a025
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  • 6
    Electronic Resource
    Electronic Resource
    Experience from one year of operating a boundary-layer profiler in the center of a large city (1994)
    Springer
    Annales geophysicae 12 (1994), S. 529-540 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Since May 1992 a small, 915-MHz profiler has been operated continuously in downtown Montreal. It is a five-beam system employing a microstrip array antenna, located atop a 14-story office building that houses several academic departments of McGill University. The data are used for research on precipitation physics and the clear-air reflectivity in addition to wind profiling. We are especially interested in situations in which the reflectivities of the clear air and the precipitation are comparable. This permits the study of interactions between the precipitation and the clear air, a new area of research made possible by wind profilers. On clear days in the summer, 30-min consensus winds can often be measured to an altitude of 3 km, but ground clutter in the antenna sidelobes interferes with measurements below 600 m. Rain when present often permits wind profiling down to 100 m and up to 6 km or higher. On cold winter days there are some periods when the reflectivity is too weak at all levels to permit wind estimation. Falling snow, however, provides readily detectable echoes and serves as a good tracer of the wind and so allows profiling over its full altitude extent. The best conditions for observing interactions between precipitation and the clear air are when light rain falls through a reflective layer associated with a frontal surface or inversion. Unexpectedly, flocks of migrating birds sometimes completely dominate the signal at night in the spring and fall seasons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-994-0529-y
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  • 7
    Electronic Resource
    Electronic Resource
    Dispersion of Toxic Combustion Products from Large Fires (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 11 (1991), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1991.tb00621.x
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  • 8
    Electronic Resource
    Electronic Resource
    Quantified Risk Assessment of Petrochemical Installations and Pipelines in the United Kingdom (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 11 (1991), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1991.tb00622.x
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  • 9
    Electronic Resource
    Electronic Resource
    Polycapillary optic–source combinations for protein crystallography (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 34 (2001), S. 330-335 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The work in this paper is a systematic study of the application of collimating and slightly focusing polycapillary optics to the X-ray crystallographic structure determination of egg-white lysozyme using two different sources: a standard rotating anode source and a low-power table-top microfocusing source. For the rotating anode source, a series of measurements comparing duplicate data sets obtained from the same individual crystal are summarized. Intensity and data quality are discussed for measurements with a pinhole collimator, a collimating polycapillary optic and a focusing polycapillary optic. The collected data were analyzed using conventional analysis software; limitations of the use of conventional analysis software for focused beams are discussed. Two data sets were collected using the low-power source and collimating optics, and three data sets using a lower-power source and focusing optics with three different limiting apertures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S002188980100468X
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  • 10
    Electronic Resource
    Electronic Resource
    Dispersion of toxic combustion products from large fires (1992)
    Springer
    Fire technology 28 (1992), S. 168-173 
    Details
    ISSN: 1572-8099
    Keywords: Fires ; combustion products ; dispersion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Conclusions The computer models discussed here are used by MHAU to give an initial indication of the possible hazards to the local population from the dispersion of combustion products from large fires. Agreement between the computer model and the wind tunnel data is encouraging, particularly at relatively low values of the buoyancy flux parameterF U −3 L −1. HSE is proposing to commence large-scale dispersion trials in the open air in the near future. It is hoped that this will enable greater confidence to be had in the predictions of the computer models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01857943
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