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  • 1
    Publication Date: 2012-09-14
    Description: Mutation in CUL4B , which encodes a scaffold protein of the E3 ubiquitin ligase complex, has been found in patients with X-linked mental retardation (XLMR). However, early deletion of Cul4b in mice causes prenatal lethality, which has frustrated attempts to characterize the phenotypes in vivo . In this report, we successfully rescued Cul4b mutant mice by crossing female mice in which exons 4–5 of Cul4b were flanked by loxP sequences with Sox2-Cre male mice. In Cul4b -deficient ( Cul4b /Y ) mice, no CUL4B protein was detected in any of the major organs, including the brain. In the hippocampus, the levels of CUL4A, CUL4B substrates (TOP1, β-catenin, cyclin E and WDR5) and neuronal markers (MAP2, tau-1, GAP-43, PSD95 and syn-1) were not sensitive to Cul4b deletion, whereas the number of parvalbumin (PV)-positive GABAergic interneurons was decreased in Cul4b /Y mice, especially in the dentate gyrus (DG). Some dendritic features, including the complexity, diameter and spine density in the CA1 and DG hippocampal neurons, were also affected by Cul4b deletion. Together, the decrease in the number of PV-positive neurons and altered dendritic properties in Cul4b /Y mice imply a reduction in inhibitory regulation and dendritic integration in the hippocampal neural circuit, which lead to increased epileptic susceptibility and spatial learning deficits. Our results identify Cul4b /Y mice as a potential model for the non-syndromic model of XLMR that replicates the CUL4B -associated MR and is valuable for the development of a therapeutic strategy for treating MR.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 2
    Publication Date: 2019-11-04
    Description: The China Digital Seismograph Network (CDSN) program was initiated in May 1983. On October 1, 1986, the CDSN began to distribute the network-day tapes to the research community. On October 22, 1987, the CDSN began full operation. The CDSN are supported by the State Seismological Bureau, People's Republic of China and the United States Geological Survey. The operation and maintenance of the network are taken by the staffs at the 10th Division of the Institute of Geophysics, State Seismological Bureau, QGSSB). At present the CDSN includes ten field stations, Le Beijing (BR), Lanzhou (LZH), Enshi (ENH), Kunming (KMI), Qiongzhong (QIZ), Shanghai (SSE), Urumqi (WMQ), Hailar (HIA), Mudanjiang (MDJ), and Lhasa (LSA), two national centers, i.e. the Network Maintenance Center (NMC) and the Data Management Center (DMC), both at the Institute of Geophysics, State Seismological Bureau, Beijing.
    Description: JCR Journal
    Description: open
    Keywords: 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Format: 1031177 bytes
    Format: application/pdf
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  • 3
    Publication Date: 2022-06-09
    Description: Following the 2009 L'Aquila earthquake, the Dipartimento della Protezione Civile Italiana (DPC), appointed an International Commission on Earthquake Forecasting for Civil Protection (ICEF) to report on the current state of knowledge of short-term prediction and forecasting of tectonic earthquakes and indicate guidelines for utilization of possible forerunners of large earthquakes to drive civil protection actions, including the use of probabilistic seismic hazard analysis in the wake of a large earthquake. The ICEF reviewed research on earthquake prediction and forecasting, drawing from developments in seismically active regions worldwide. A prediction is defined as a deterministic statement that a future earthquake will or will not occur in a particular geographic region, time window, and magnitude range, whereas a forecast gives a probability (greater than zero but less than one) that such an event will occur. Earthquake predictability, the degree to which the future occurrence of earthquakes can be determined from the observable behavior of earthquake systems, is poorly understood. This lack of understanding is reflected in the inability to reliably predict large earthquakes in seismically active regions on short time scales. Most proposed prediction methods rely on the concept of a diagnostic precursor; i.e., some kind of signal observable before earthquakes that indicates with high probability the location, time, and magnitude of an impending event. Precursor methods reviewed here include changes in strain rates, seismic wave speeds, and electrical conductivity; variations of radon concentrations in groundwater, soil, and air; fluctuations in groundwater levels; electromagnetic variations near and above Earth's surface; thermal anomalies; anomalous animal behavior; and seismicity patterns. The search for diagnostic precursors has not yet produced a successful short-term prediction scheme. Therefore, this report focuses on operational earthquake forecasting as the principle means for gathering and disseminating authoritative information about time-dependent seismic hazards to help communities prepare for potentially destructive earthquakes. On short time scales of days and weeks, earthquake sequences show clustering in space and time, as indicated by the aftershocks triggered by large events. Statistical descriptions of clustering explain many features observed in seismicity catalogs, and they can be used to construct forecasts that indicate how earthquake probabilities change over the short term. Properly applied, short-term forecasts have operational utility; for example, in anticipating aftershocks that follow large earthquakes. Although the value of long-term forecasts for ensuring seismic safety is clear, the interpretation of short-term forecasts is problematic, because earthquake probabilities may vary over orders of magnitude but typically remain low in an absolute sense (〈 1% per day). Translating such low-probability forecasts into effective decision-making is a difficult challenge. Reports on the current utilization operational forecasting in earthquake risk management were compiled for six countries with high seismic risk: China, Greece, Italy, Japan, Russia, United States. Long-term models are currently the most important forecasting tools for civil protection against earthquake damage, because they guide earthquake safety provisions of building codes, performance-based seismic design, and other risk-reducing engineering practices, such as retrofitting to correct design flaws in older buildings. Short-term forecasting of aftershocks is practiced by several countries among those surveyed, but operational earthquake forecasting has not been fully implemented (i.e., regularly updated and on a national scale) in any of them. Based on the experience accumulated in seismically active regions, the ICEF has provided to DPC a set of recommendations on the utilization of operational forecasting in Italy, which may also be useful in other countries. The public should be provided with open sources of information about the short-term probabilities of future earthquakes that are authoritative, scientific, consistent, and timely. Advisories should be based on operationally qualified, regularly updated seismicity forecasting systems that have been rigorously reviewed and updated by experts in the creation, delivery, and utility of earthquake information. The quality of all operational models should be evaluated for reliability and skill by retrospective testing, and they should be under continuous prospective testing against established long-term forecasts and alternative time-dependent models. Alert procedures should be standardized to facilitate decisions at different levels of government and among the public. Earthquake probability thresholds should be established to guide alert levels based on objective analysis of costs and benefits, as well as the less tangible aspects of value-of-information, such as gains in psychological preparedness and resilience. The principles of effective public communication established by social science research should be applied to the delivery of seismic hazard information.
    Description: Published
    Description: 315-391
    Description: 4.2. TTC - Modelli per la stima della pericolosità sismica a scala nazionale
    Description: JCR Journal
    Description: open
    Keywords: earthquake forecasting ; decision making ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
    ISSN: 1420-9136
    Keywords: Qinghai-Xizang (Tibetan) plateau ; source process ; moment tensor ; tectonic stress field
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract TheM s =6.9 Gonghe, China, earthquake of April 26, 1990 is the largest earthquake to have been documented historically as well as recorded instrumentally in the northeastern Qinghai-Xizang (Tibetan) plateau. The source process of this earthquake and the tectonic stress field in the northeastern Qinghai-Xizang plateau are investigated using geodetic and seismic data. The leveling data are used to invert the focal mechanism, the shape of the slipped region and the slip distribution on the fault plane. It is obtained through inversion of the leveling data that this earthquake was caused by a mainly reverse dip-slipping buried fault with strike 102°, dip 46° to SSW, rake 86° and a seismic moment of 9,4×1018 Nm. The stress drop, strain and energy released for this earthquake are estimated to be 4.9 MPa, 7.4×10−5 and 7.0×1014 J, respectively. The slip distributes in a region slightly deep from NWW to SEE, with two nuclei, i.e., knots with highly concentrated slip, located in a shallower depth in the NWW and a deeper depth in the SEE, respectively. Broadband body waves data recorded by the China Digital Seismograph Network (CDSN) for the Gonghe earthquake are used to retrieve the source process of the earthquakes. It is found through moment-tensor inversion that theM s =6.9 main shock is a complex rupture process dominated by shear faulting with scalar seismic moment of the best double-couple of 9.4×1018 Nm, which is identical to the seismic moment determined from leveling data. The moment rate tensor functions reveal that this earthquake consists of three consecutive events. The first event, with a scalar seismic moment of 4.7×1018 Nm, occurred between 0–12 s, and has a focal mechanism similar to that inverted from leveling data. The second event, with a smaller seismic moment of 2.1×1018 Nm, occurred between 12–31 s, and has a variable focal mechanism. The third event, with a sealar seismic moment of 2.5×1018 Nm, occurred between 31–41 s, and has a focal mechanism similar to that inverted from leveling data. The strike of the 1990 Gonghe earthquake, and the significantly reverse dip-slip with minor left-lateral strike-slip motion suggest that the pressure axis of the tectonic stress field in the northeastern Qinghai-Xizang plateau is close to horizontal and oriented NNE to SSW, consistent with the relative collision motion between the Indian and Eurasian plates. The predominant thrust mechanism and the complexity in the tempo-spatial rupture process of the Gonghe earthquake, as revealed by the geodetic and seismic data, is generally consistent with the overall distribution of isoseismals, aftershock seismicity and the geometry of intersecting faults structure in the Gonghe basin of the northeastern Qinghai-Xizang plateau.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 147 (1996), S. 357-366 
    ISSN: 1420-9136
    Keywords: Seismic moment tensor ; underground nuclear explosion ; tectonic strain release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Generally the decomposition of a seismic moment tensor is not unique. However, to favorably view the characteristics of a certain seismic source, one must decompose a seismic moment tensor into parts according to assumptions about the properties of the seismic source. Different from natural earthquakes in which the shear dislocation component plays a predominant role in the source process, and the seismic moment tensor can be separated into an isotropic component, a double couple, and a compensated linear vector dipole (CLVD), underground nuclear explosions have three major components in their source process, i.e., the explosion, the tensional spalling, and the tectonic strain release associated with the explosion. In such a situation the conventional moment tensor decomposition for earthquakes is not convenient to estimate the yield of the explosion and to characterize the tectonic strain release. In this paper, an alternative decomposition scheme is proposed to deal with the moment tensor of underground nuclear explosions, which might benefit the approach to study the tectonic strain release induced by underground nuclear detonations.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 171 (1953), S. 348-349 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experimental facts are as follows. The y-lactones of D-glucuronic acid and L-gulonic acid, when fed to cress seedlings or injected into rats, were found to be transformed, into L-ascorbic acid. D-Galacturonic acid methyl ester, and L-galactonic acid y-lactone behaved similarly. No other sugar ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 104 (1982), S. 641-648 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Genomics 13 (1992), S. 931-934 
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 143 (1987), S. 863-871 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 190 (1992), S. 507-513 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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