ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Two decades of anarchy? Emerging themes and outstanding challenges for neural network river forecasting (2012)
    Sage
    Details
    Publication Date: 2012-07-14
    Description: This paper traces two decades of neural network rainfall-runoff and streamflow modelling, collectively termed ‘river forecasting’. The field is now firmly established and the research community involved has much to offer hydrological science. First, however, it will be necessary to converge on more objective and consistent protocols for: selecting and treating inputs prior to model development; extracting physically meaningful insights from each proposed solution; and improving transparency in the benchmarking and reporting of experimental case studies. It is also clear that neural network river forecasting solutions will have limited appeal for operational purposes until confidence intervals can be attached to forecasts. Modular design, ensemble experiments, and hybridization with conventional hydrological models are yielding new tools for decision-making. The full potential for modelling complex hydrological systems, and for characterizing uncertainty, has yet to be realized. Further gains could also emerge from the provision of an agreed set of benchmark data sets and associated development of superior diagnostics for more rigorous intermodel evaluation. To achieve these goals will require a paradigm shift, such that the mass of individual isolated activities, focused on incremental technical refinement, is replaced by a more coordinated, problem-solving international research body.
    Print ISSN: 0309-1333
    Electronic ISSN: 1477-0296
    Topics: Geography
    Published by Sage
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-15
    Description: Myelination of the central nervous system requires the generation of functionally mature oligodendrocytes from oligodendrocyte precursor cells (OPCs). Electrically active neurons may influence OPC function and selectively instruct myelination of an active neural circuit. In this work, we use optogenetic stimulation of the premotor cortex in awake, behaving mice to demonstrate that neuronal activity elicits a mitogenic response of neural progenitor cells and OPCs, promotes oligodendrogenesis, and increases myelination within the deep layers of the premotor cortex and subcortical white matter. We further show that this neuronal activity-regulated oligodendrogenesis and myelination is associated with improved motor function of the corresponding limb. Oligodendrogenesis and myelination appear necessary for the observed functional improvement, as epigenetic blockade of oligodendrocyte differentiation and myelin changes prevents the activity-regulated behavioral improvement.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096908/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096908/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, Erin M -- Purger, David -- Mount, Christopher W -- Goldstein, Andrea K -- Lin, Grant L -- Wood, Lauren S -- Inema, Ingrid -- Miller, Sarah E -- Bieri, Gregor -- Zuchero, J Bradley -- Barres, Ben A -- Woo, Pamelyn J -- Vogel, Hannes -- Monje, Michelle -- 1S10RR02678001/RR/NCRR NIH HHS/ -- K08 NS070926/NS/NINDS NIH HHS/ -- K08NS070926/NS/NINDS NIH HHS/ -- R01 EY10257/EY/NEI NIH HHS/ -- T32 MH020016/MH/NIMH NIH HHS/ -- UL1 RR025744/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 May 2;344(6183):1252304. doi: 10.1126/science.1252304. Epub 2014 Apr 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Neurology, Neurosurgery, and Pediatrics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24727982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Thy-1/genetics ; Behavior, Animal/physiology ; *Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Corpus Callosum/cytology/physiology ; Mice ; Mice, Mutant Strains ; Motor Activity/physiology ; Motor Cortex/cytology/*physiology ; Myelin Sheath/*metabolism ; Nerve Fibers, Myelinated/*metabolism ; Neural Stem Cells/*physiology ; Neurons/*physiology ; Oligodendroglia/*cytology ; Rhodopsin/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...