Publication Date:
2008-11-01
Description:
Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701511/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701511/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, Bret R -- Prabhu, Vineet R -- Hunter, Karen E -- Glazier, Christina M -- Whittaker, Charles A -- Housman, David E -- Amon, Angelika -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Oct 31;322(5902):703-9. doi: 10.1126/science.1160058.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18974345" target="_blank"〉PubMed〈/a〉
Keywords:
*Aneuploidy
;
Animals
;
Cell Aging
;
Cell Cycle
;
Cell Line
;
*Cell Proliferation
;
Cell Size
;
Cell Transformation, Neoplastic
;
Culture Media
;
Embryo, Mammalian
;
Fibroblasts
;
Gene Dosage
;
*Gene Expression
;
Genomic Instability
;
Glucose/*metabolism
;
Glutamine/*metabolism
;
Metabolic Networks and Pathways
;
Mice
;
Serial Passage
;
Translocation, Genetic
;
*Trisomy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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